Reluctant to move: in adverse event reports for animal drugs

Clinical sign, a VeDDRA term

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarian How to report to FDA

From January 1989 to June 2026, FDA received 5,671 adverse event reports for animal drugs that list this sign. That is 0.4% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 446 reports that list this sign.

Of the 5,671 reports, 80.7% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 114 of 1,149 clinical signs with a page. Reports that list this sign rose by 6.2% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 80.7% of the reports that list this sign, and 72.6% of all reports.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 85 drug pages.

Show the 85 drug pages

Drug pages with 20 or more reports that list this sign, in order of name
Active ingredients	Reports that list the sign
(S) - methoprene	23
Afoxolaner	179
Afoxolaner + Moxidectin + Pyrantel Pamoate	25
Amoxicillin	43
Amoxicillin + Clavulanate Potassium	27
Amoxicillin Trihydrate + Clavulanate Potassium	43
Atipamezole Hydrochloride	33
Bedinvetmab	323
Buprenorphine	124
Butorphanol Tartrate	82
Capromorelin	25
Carprofen	585
Cefovecin sodium	147
Cefpodoxime proxetil	41
Ceftiofur Crystalline Free Acid	22
Cyclosporine	76
Deracoxib	140
Dexamethasone	56
Dexmedetomidine	39
Dexmedetomidine hydrochloride	28
Diphenhydramine	81
Doxycycline	47
Emodepside + Praziquantel	24
Enrofloxacin	70
Eprinomectin + Esafoxolaner + Praziquantel	27
Famotidine	67
Febantel + Praziquantel + Pyrantel Pamoate	20
Fenbendazole	23
Fentanyl	23
Firocoxib	116
Florfenicol + Mometasone furoate + Terbinafine	42
Fluralaner	377
Frunevetmab	68
Gabapentin	222
Grapiprant	78
Hydromorphone	20
Imidacloprid	44
Imidacloprid + Moxidectin	87
Insulin	55
Isoflurane	56
Ivermectin	79
Ivermectin + Praziquantel + Pyrantel Pamoate	26
Ivermectin + Pyrantel Pamoate	256
Ketamine Hydrochloride	38
Ketoconazole	22
Levothyroxine sodium	22
Lotilaner	50
Lufenuron + Milbemycin Oxime	68
Lufenuron + Milbemycin Oxime + Praziquantel	23
Marbofloxacin	34
Maropitant	233
Melarsomine Dihydrochloride	213
Meloxicam	163
Metronidazole	45
Midazolam	21
Milbemycin Oxime	66
Milbemycin Oxime + Praziquantel	84
Milbemycin Oxime + Spinosad	396
Mirtazapine	21
Monensin	24
Moxidectin	327
Nitazoxanide	20
Nitenpyram	76
Oclacitinib	120
Omeprazole	23
Ondansetron	20
Pimobendan	36
Polysulfated Glycosaminoglycan	79
Praziquantel + Pyrantel Pamoate	44
Prednisolone	32
Prednisone	121
Propofol	33
Pyrantel Pamoate	34
Pyrantel Pamoate + Sarolaner	119
Robenacoxib	61
Sarolaner	69
Sarolaner + Selamectin	30
Selamectin	155
Selegiline Hydrochloride	25
Spinosad	212
Sucralfate	22
Tigilanol tiglate	91
Tramadol	64
Trazodone	30
Trilostane	113

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 82 ingredients.

Show the 82 ingredients

Reports by species

Dog80.7%4,575
Cat12.8%726
Horse3.2%179
Cattle1.8%100
Pig0.7%39
Turkey0.2%9

The share is of the 5,671 reports that list this sign. The sign is in 0.5% of all reports about the species dog. The sign is in 0.5% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Reluctant to move, by the year in which FDA received them
Year	Reports
2026	217
2025	427
2024	446
2023	291
2022	209
2021	229
2020	170
2019	218
2018	177
2017	238
2016	226
2015	234
2014	194
2013	256
2012	242
2011	227
2010	256
2009	248
2008	195
2007	125
2006	148
2005	127
2004	152
2003	105
2002	90
2001	74
2000	69
1999	34
1998	24
1997	4
1996	11
1995	3
1992	1
1991	2
1989	2

What these reports record

Outcome at the time of the report

Reports with this sign
All reports

Recovered/Normal18.5%1,047, All reports: 20.7%
Recovered with Sequela[recovered, with a lasting effect]1.3%73, All reports: 2.3%
Ongoing19.4%1,103, All reports: 17.4%
Died15.1%854, All reports: 4.9%
Euthanized6.4%362, All reports: 1.5%
Outcome Unknown15.4%875, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 5,671 reports that list this sign.

Age of the animal

Reports with this sign
All reports

Under 1 year9.4%532, All reports: 9.5%
1 to 3 years17.4%984, All reports: 23.9%
4 to 7 years22.3%1,262, All reports: 20.2%
8 to 11 years25.8%1,464, All reports: 15.4%
12 years and over20.9%1,185, All reports: 10.7%
Age not given4.3%244, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

Reduced globulins
Reduced responses
Regenerative anaemia
Regurgitation
Renal disorder NOS[kidney disorder, type not specified]
Renal failure[kidney failure]
Renal insufficiency
Residues in meat/offal

All clinical signs

Cite this page

Pet Drug Reports. Reluctant to move: adverse event reports for animal drugs. https://petdrugreports.com/reaction/reluctant-to-move/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?: It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.
How does the count of the latest 12 months compare with the 12 months before?: FDA received 446 reports in the 12 months to June 2026. It received 420 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
How many of these reports have a serious flag?: Of the 3,695 reports that say if the event was serious, 59.6% have the serious flag. The person who sends a report sets the flag.
Does a drug in the table cause this sign?: The reports do not show that. A report can name more than one drug. FDA states this about the data.
When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices