Hyperactivity: in adverse event reports for animal drugs

Clinical sign, a VeDDRA term

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarian How to report to FDA

From February 1987 to June 2026, FDA received 10,958 adverse event reports for animal drugs that list this sign. That is 0.8% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 475 reports that list this sign.

Of the 10,958 reports, 54.4% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 56 of 1,149 clinical signs with a page. Reports that list this sign fell by 9.5% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about cats are 42.4% of the reports that list this sign, and 11% of all reports.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 87 drug pages.

Show the 87 drug pages

Drug pages with 20 or more reports that list this sign, in order of name
Active ingredients	Reports that list the sign
(S) - methoprene	267
Acepromazine Maleate	49
Afoxolaner	327
Afoxolaner + Moxidectin + Pyrantel Pamoate	26
Alfaxalone	29
Amoxicillin	32
Atipamezole Hydrochloride	126
Atropine	24
Bedinvetmab	48
Bupivacaine	22
Buprenorphine	581
Butorphanol Tartrate	169
Capromorelin	21
Carprofen	356
Cefovecin sodium	168
Cefpodoxime proxetil	34
Clomipramine Hydrochloride	43
Cyclosporine	324
Deracoxib	103
Dexamethasone	29
Dexmedetomidine	99
Dexmedetomidine hydrochloride	62
Diazepam	29
Diphenhydramine	46
Dirlotapide	21
Emodepside + Praziquantel	108
Enalapril Maleate	20
Enrofloxacin	47
Eprinomectin + Esafoxolaner + Praziquantel	63
Famotidine	21
Febantel + Praziquantel + Pyrantel Pamoate	307
Fenbendazole	89
Firocoxib	79
Fluoxetine hydrochloride	48
Fluralaner	378
Fluralaner + Moxidectin	70
Frunevetmab	30
Gabapentin	90
Grapiprant	36
Hydromorphone	21
Imidacloprid	123
Imidacloprid + Moxidectin	838
Isoflurane	151
Ivermectin	131
Ivermectin + Praziquantel + Pyrantel Pamoate	30
Ivermectin + Pyrantel Pamoate	393
Ketamine Hydrochloride	174
Levothyroxine sodium	33
Lotilaner	115
Lufenuron + Milbemycin Oxime	91
Maropitant	118
Medetomidine	60
Melarsomine Dihydrochloride	59
Meloxicam	133
Methylprednisolone Acetate	23
Metronidazole	42
Midazolam	76
Milbemycin Oxime	124
Milbemycin Oxime + Praziquantel	62
Milbemycin Oxime + Spinosad	258
Mirtazapine	50
Moxidectin	149
Nitenpyram	2,558
Oclacitinib	133
Ormetoprim + Sulfadimethoxine	44
Penicillin G Procaine	24
Pentobarbital	27
Pimobendan	44
Praziquantel	29
Praziquantel + Pyrantel Pamoate	36
Prednisolone	21
Prednisolone + Trimeprazine Tartrate	21
Prednisone	51
Propofol	113
Pyrantel Pamoate	23
Pyrantel Pamoate + Sarolaner	198
Robenacoxib	117
Sarolaner	112
Sarolaner + Selamectin	95
Selamectin	588
Selegiline Hydrochloride	183
Sevoflurane	25
Spinosad	410
Tiletamine Hydrochloride + Zolazepam Hydrochloride	68
Tramadol	25
Trilostane	45
Xylazine	29

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 83 ingredients.

Show the 83 ingredients

Reports by species

Dog54.4%5,956
Cat42.4%4,642
Horse1.6%176
Cattle0.8%83
Pig0.5%52
Other0.1%10

The share is of the 10,958 reports that list this sign. The sign is in 0.6% of all reports about the species dog. The sign is in 3.1% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Hyperactivity, by the year in which FDA received them
Year	Reports
2026	211
2025	469
2024	574
2023	598
2022	467
2021	414
2020	396
2019	382
2018	385
2017	526
2016	474
2015	463
2014	442
2013	411
2012	405
2011	446
2010	529
2009	515
2008	457
2007	403
2006	312
2005	283
2004	228
2003	162
2002	165
2001	182
2000	229
1999	116
1998	95
1997	39
1996	25
1995	27
1994	20
1993	8
1992	15
1991	12
1990	13
1989	23
1988	19
1987	18

What these reports record

Outcome at the time of the report

Reports with this sign
All reports

Recovered/Normal27.6%3,023, All reports: 20.7%
Recovered with Sequela[recovered, with a lasting effect]0.6%61, All reports: 2.3%
Ongoing12.3%1,343, All reports: 17.4%
Died3.7%401, All reports: 4.9%
Euthanized0.7%78, All reports: 1.5%
Outcome Unknown19.2%2,100, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 10,958 reports that list this sign.

Age of the animal

Reports with this sign
All reports

Under 1 year18.1%1,979, All reports: 9.5%
1 to 3 years27.2%2,984, All reports: 23.9%
4 to 7 years20.9%2,287, All reports: 20.2%
8 to 11 years13.5%1,478, All reports: 15.4%
12 years and over12.2%1,340, All reports: 10.7%
Age not given8.1%890, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

Hives
Horizontal nystagmus
Horner's syndrome
Hot spot (pyotraumatic dermatitis)[moist, inflamed patch of skin]
Hyperadrenocorticism
Hyperaemic mucous membrane
Hyperaesthesia[over-sensitive to touch]
Hyperalbuminaemia

All clinical signs

Cite this page

Pet Drug Reports. Hyperactivity: adverse event reports for animal drugs. https://petdrugreports.com/reaction/hyperactivity/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?: It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.
How does the count of the latest 12 months compare with the 12 months before?: FDA received 475 reports in the 12 months to June 2026. It received 525 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
How many of these reports have a serious flag?: Of the 6,564 reports that say if the event was serious, 29.8% have the serious flag. The person who sends a report sets the flag.
Does a drug in the table cause this sign?: The reports do not show that. A report can name more than one drug. FDA states this about the data.
When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices