Inappetence: in adverse event reports for animal drugs

Clinical sign, a VeDDRA term

In plain words: reduced appetite.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarian How to report to FDA

From March 2005 to June 2026, FDA received 9,225 adverse event reports for animal drugs that list this sign. That is 0.7% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 470 reports that list this sign.

Of the 9,225 reports, 80.5% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 70 of 1,149 clinical signs with a page. Reports that list this sign fell by 22.7% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 80.5% of the reports that list this sign, and 72.6% of all reports.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 109 drug pages.

Show the 109 drug pages

Drug pages with 20 or more reports that list this sign, in order of name
Active ingredients	Reports that list the sign
(S) - methoprene	36
Acepromazine Maleate	48
Afoxolaner	725
Afoxolaner + Moxidectin + Pyrantel Pamoate	103
Amoxicillin	56
Amoxicillin + Clavulanate Potassium	54
Amoxicillin Trihydrate + Clavulanate Potassium	78
Atipamezole Hydrochloride	32
Atropine	24
Bedinvetmab	211
Bexagliflozin	59
Buprenorphine	149
Butorphanol Tartrate	94
Capromorelin	51
Carprofen	590
Cefovecin sodium	305
Cefpodoxime proxetil	86
Cephalexin	52
Clindamycin	30
Cyclosporine	190
Deracoxib	107
Desoxycorticosterone Pivalate	29
Dexamethasone	95
Dexamethasone + Neomycin Sulfate + Thiabendazole	31
Dexamethasone Sodium Phosphate	24
Dexmedetomidine	40
Dexmedetomidine hydrochloride	43
Diazepam	24
Diphenhydramine	128
Doxycycline	74
Emodepside + Praziquantel	93
Enalapril Maleate	38
Enrofloxacin	113
Eprinomectin + Esafoxolaner + Praziquantel	69
Estriol	26
Famotidine	128
Febantel + Praziquantel + Pyrantel Pamoate	67
Fenbendazole	22
Fentanyl	60
Firocoxib	149
Florfenicol + Mometasone furoate + Terbinafine	73
Florfenicol + Terbinafine	20
Fluoxetine hydrochloride	33
Fluralaner	834
Fluralaner + Moxidectin	29
Frunevetmab	83
Furosemide	47
Gabapentin	225
Grapiprant	175
Hydromorphone	42
Ilunocitinib	32
Imidacloprid	62
Imidacloprid + Moxidectin	285
Insulin	98
Isoflurane	100
Ivermectin	92
Ivermectin + Praziquantel + Pyrantel Pamoate	80
Ivermectin + Pyrantel Pamoate	605
Ketamine Hydrochloride	56
Ketoconazole	41
Levothyroxine sodium	75
Lotilaner	78
Lotilaner + Moxidectin + Praziquantel + Pyrantel Pamoate	23
Lufenuron + Milbemycin Oxime	203
Lufenuron + Milbemycin Oxime + Praziquantel	41
Lufenuron + Praziquantel	46
Marbofloxacin	31
Maropitant	473
Melarsomine Dihydrochloride	178
Meloxicam	167
Methimazole	28
Methylprednisolone Acetate	48
Metronidazole	106
Midazolam	47
Milbemycin Oxime	65
Milbemycin Oxime + Praziquantel	142
Milbemycin Oxime + Spinosad	876
Mirtazapine	77
Moxidectin	326
Nitenpyram	95
Oclacitinib	348
Omeprazole	53
Ondansetron	37
Pergolide mesylate	71
Phenobarbital	24
Pimobendan	96
Polysulfated Glycosaminoglycan	95
Praziquantel + Pyrantel Pamoate	55
Prednisolone	54
Prednisone	213
Propofol	63
Pyrantel Pamoate	44
Pyrantel Pamoate + Sarolaner	237
Robenacoxib	89
Sarolaner	206
Sarolaner + Selamectin	59
Selamectin	223
Sevoflurane	20
Spinosad	284
Sucralfate	58
Telmisartan	22
Tigilanol tiglate	41
Toceranib Phosphate	27
Tramadol	153
Trazodone	43
Trilostane	434
Ursodiol	21
Velagliflozin	85
Vitamin E	30

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 105 ingredients.

Show the 105 ingredients

Reports by species

Dog80.5%7,425
Cat17.2%1,587
Horse1.4%133
Rabbit0.3%28
Cattle0.2%21
Ferret0.1%5

The share is of the 9,225 reports that list this sign. The sign is in 0.7% of all reports about the species dog. The sign is in 1% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Inappetence, by the year in which FDA received them
Year	Reports
2026	226
2025	518
2024	700
2023	462
2022	362
2021	357
2020	521
2019	571
2018	746
2017	928
2016	801
2015	882
2014	861
2013	600
2012	564
2011	99
2010	11
2009	4
2008	4
2007	2
2006	1
2005	5

What these reports record

Outcome at the time of the report

Reports with this sign
All reports

Recovered/Normal30.1%2,773, All reports: 20.7%
Recovered with Sequela[recovered, with a lasting effect]2%183, All reports: 2.3%
Ongoing28.2%2,604, All reports: 17.4%
Died4.8%446, All reports: 4.9%
Euthanized7.3%670, All reports: 1.5%
Outcome Unknown27.9%2,578, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 9,225 reports that list this sign.

Age of the animal

Reports with this sign
All reports

Under 1 year10.2%939, All reports: 9.5%
1 to 3 years21.2%1,954, All reports: 23.9%
4 to 7 years23%2,122, All reports: 20.2%
8 to 11 years24.5%2,264, All reports: 15.4%
12 years and over18.1%1,669, All reports: 10.7%
Age not given3%277, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

All clinical signs

Cite this page

Pet Drug Reports. Inappetence: adverse event reports for animal drugs. https://petdrugreports.com/reaction/inappetence/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?: In plain words: reduced appetite. It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.
How does the count of the latest 12 months compare with the 12 months before?: FDA received 470 reports in the 12 months to June 2026. It received 608 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
How many of these reports have a serious flag?: Of the 9,185 reports that say if the event was serious, 53.3% have the serious flag. The person who sends a report sets the flag.
Does a drug in the table cause this sign?: The reports do not show that. A report can name more than one drug. FDA states this about the data.
When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices