Pet Drug Reports

Hypersalivation: in adverse event reports for animal drugs

Clinical sign, a VeDDRA term

In plain words: drooling.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarianHow to report to FDA

From January 1987 to June 2026, FDA received 16,000 adverse event reports for animal drugs that list this sign. That is 1.2% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 500 reports that list this sign.

Of the 16,000 reports, 54.2% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 33 of 1,149 clinical signs with a page. Reports that list this sign fell by 6.2% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about cats are 38.7% of the reports that list this sign, and 11% of all reports.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 120 drug pages.

Show the 120 drug pages
Drug pages with 20 or more reports that list this sign, in order of name
Active ingredientsReports that list the sign
(S) - methoprene79
Acepromazine Maleate49
Afoxolaner427
Afoxolaner + Moxidectin + Pyrantel Pamoate35
Amitraz21
Amoxicillin107
Amoxicillin + Clavulanate Potassium46
Amoxicillin Trihydrate + Clavulanate Potassium43
Atipamezole Hydrochloride269
Atropine33
Bedinvetmab69
Buprenorphine242
Butorphanol Tartrate216
Capromorelin205
Carprofen540
Cefovecin sodium281
Cefpodoxime proxetil46
Cephalexin30
Clomipramine Hydrochloride24
Cyclosporine397
Deracoxib181
Dexamethasone75
Dexamethasone Sodium Phosphate35
Dexmedetomidine60
Dexmedetomidine hydrochloride216
Diazepam35
Dichlorophene + Toluene58
Diphenhydramine126
Dirlotapide20
Doramectin43
Doxycycline67
Emodepside + Praziquantel1,085
Enrofloxacin137
Eprinomectin35
Eprinomectin + Esafoxolaner + Praziquantel292
Eprinomectin + Praziquantel98
Famotidine96
Famphur28
Febantel + Praziquantel + Pyrantel Pamoate79
Fenbendazole66
Fenthion24
Firocoxib88
Florfenicol + Mometasone furoate + Terbinafine75
Fluoxetine hydrochloride39
Fluralaner642
Fluralaner + Moxidectin127
Frunevetmab25
Gabapentin135
Grapiprant41
Hydromorphone24
Imidacloprid87
Imidacloprid + Moxidectin1,718
Imidocarb Dipropionate30
Insulin32
Isoflurane107
Ivermectin526
Ivermectin + Praziquantel355
Ivermectin + Praziquantel + Pyrantel Pamoate104
Ivermectin + Pyrantel Pamoate621
Ketamine Hydrochloride122
Ketoconazole23
Levamisole Hydrochloride24
Levamisole Phosphate22
Lincomycin Hydrochloride Monohydrate + Spectinomycin Sulfate Tetrahydrate44
Lotilaner77
Lotilaner + Moxidectin + Praziquantel + Pyrantel Pamoate23
Lufenuron33
Lufenuron + Milbemycin Oxime180
Lufenuron + Milbemycin Oxime + Praziquantel28
Marbofloxacin32
Maropitant823
Medetomidine89
Melarsomine Dihydrochloride894
Meloxicam172
Methocarbamol25
Methylprednisolone Acetate40
Metoclopramide27
Metronidazole70
Midazolam55
Milbemycin Oxime312
Milbemycin Oxime + Praziquantel153
Milbemycin Oxime + Spinosad668
Mirtazapine69
Monensin30
Moxidectin465
Moxidectin + Praziquantel25
Nitenpyram236
Oclacitinib106
Omeprazole34
Ondansetron43
Orbifloxacin37
Ormetoprim + Sulfadimethoxine29
Oxytetracycline51
Phenobarbital22
Pimobendan23
Polysulfated Glycosaminoglycan31
Pradofloxacin55
Praziquantel126
Praziquantel + Pyrantel Pamoate115
Prednisolone52
Prednisone127
Propofol80
Pyrantel Pamoate97
Pyrantel Pamoate + Sarolaner135
Robenacoxib79
Sarolaner146
Sarolaner + Selamectin62
Selamectin929
Selegiline Hydrochloride50
Sevoflurane27
Spinosad690
Sucralfate44
Tepoxalin22
Tiletamine Hydrochloride + Zolazepam Hydrochloride42
Tilmicosin Phosphate33
Tramadol55
Trazodone30
Tylosin20
Velagliflozin74
Vitamin E42

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 113 ingredients.

Show the 113 ingredients

Reports by species

The share is of the 16,000 reports that list this sign. The sign is in 0.9% of all reports about the species dog. The sign is in 4.1% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Hypersalivation, by the year in which FDA received them
YearReports
2026218
2025519
2024579
2023456
2022408
2021527
2020574
2019635
2018732
2017713
2016624
2015602
2014705
2013690
2012792
2011870
20101,042
2009935
2008790
2007523
2006376
2005329
2004379
2003264
2002247
2001240
2000306
1999162
1998132
199767
199699
199579
199451
199334
199250
199124
199034
198991
198857
198745

What these reports record

Outcome at the time of the report

  • Reports with this sign
  • All reports
  • Recovered/Normal23.1%3,693, All reports: 20.7%
  • Recovered with Sequela[recovered, with a lasting effect]0.8%120, All reports: 2.3%
  • Ongoing11.6%1,850, All reports: 17.4%
  • Died10.2%1,624, All reports: 4.9%
  • Euthanized2.2%350, All reports: 1.5%
  • Outcome Unknown16.3%2,613, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 16,000 reports that list this sign.

Age of the animal

  • Reports with this sign
  • All reports
  • Under 1 year17.8%2,852, All reports: 9.5%
  • 1 to 3 years28.6%4,581, All reports: 23.9%
  • 4 to 7 years20.7%3,312, All reports: 20.2%
  • 8 to 11 years14.3%2,291, All reports: 15.4%
  • 12 years and over9.6%1,530, All reports: 10.7%
  • Age not given9%1,434, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

All clinical signs

Cite this page

Pet Drug Reports. Hypersalivation: adverse event reports for animal drugs. https://petdrugreports.com/reaction/hypersalivation/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?

In plain words: drooling. It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.

How does the count of the latest 12 months compare with the 12 months before?

FDA received 500 reports in the 12 months to June 2026. It received 533 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

How many of these reports have a serious flag?

Of the 8,760 reports that say if the event was serious, 52.8% have the serious flag. The person who sends a report sets the flag.

Does a drug in the table cause this sign?

The reports do not show that. A report can name more than one drug. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices