Neutrophilia: in adverse event reports for animal drugs

Clinical sign, a VeDDRA term

In plain words: high neutrophil count.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarian How to report to FDA

From March 1987 to June 2026, FDA received 7,090 adverse event reports for animal drugs that list this sign. That is 0.5% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 653 reports that list this sign.

Of the 7,090 reports, 83.9% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 91 of 1,149 clinical signs with a page. Reports that list this sign rose by 6.2% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 83.9% of the reports that list this sign, and 72.6% of all reports.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 110 drug pages.

Show the 110 drug pages

Drug pages with 20 or more reports that list this sign, in order of name
Active ingredients	Reports that list the sign
(S) - methoprene	26
Acepromazine Maleate	48
Afoxolaner	356
Afoxolaner + Moxidectin + Pyrantel Pamoate	54
Amoxicillin	135
Amoxicillin + Clavulanate Potassium	90
Amoxicillin Trihydrate + Clavulanate Potassium	118
Ampicillin Sodium	32
Atipamezole Hydrochloride	36
Atropine	29
Bedinvetmab	314
Bexagliflozin	51
Buprenorphine	170
Butorphanol Tartrate	137
Capromorelin	88
Carprofen	989
Cefovecin sodium	307
Cefpodoxime proxetil	86
Cephalexin	55
Clindamycin	62
Cyclosporine	190
Deracoxib	300
Desoxycorticosterone Pivalate	31
Dexamethasone	158
Dexamethasone + Neomycin Sulfate + Thiabendazole	26
Dexamethasone Sodium Phosphate	76
Dexmedetomidine	62
Dexmedetomidine hydrochloride	38
Dextrose	36
Diazepam	42
Diphenhydramine	170
Dirlotapide	25
Doxycycline	178
Emodepside + Praziquantel	27
Enalapril Maleate	20
Enrofloxacin	177
Eprinomectin + Esafoxolaner + Praziquantel	55
Estriol	20
Famotidine	164
Febantel + Praziquantel + Pyrantel Pamoate	22
Fenbendazole	32
Firocoxib	214
Florfenicol + Mometasone furoate + Terbinafine	46
Fluralaner	504
Frunevetmab	82
Furosemide	51
Gabapentin	333
Grapiprant	123
Hydromorphone	48
Ilunocitinib	47
Imidacloprid	47
Imidacloprid + Moxidectin	54
Insulin	86
Isoflurane	92
Ivermectin	84
Ivermectin + Praziquantel + Pyrantel Pamoate	20
Ivermectin + Pyrantel Pamoate	327
Ketamine Hydrochloride	65
Ketoconazole	39
Levothyroxine sodium	43
Lidocaine	25
Lotilaner	72
Lotilaner + Moxidectin + Praziquantel + Pyrantel Pamoate	26
Lufenuron + Milbemycin Oxime	64
Lufenuron + Milbemycin Oxime + Praziquantel	23
Marbofloxacin	36
Maropitant	678
Melarsomine Dihydrochloride	233
Meloxicam	239
Methadone	23
Methimazole	23
Methocarbamol	21
Methylprednisolone Acetate	53
Metoclopramide	54
Metronidazole	173
Midazolam	64
Milbemycin Oxime	60
Milbemycin Oxime + Praziquantel	133
Milbemycin Oxime + Spinosad	442
Mirtazapine	73
Moxidectin	430
Nitenpyram	49
Oclacitinib	272
Omeprazole	85
Ondansetron	79
Phenobarbital	24
Pimobendan	49
Polysulfated Glycosaminoglycan	74
Praziquantel + Pyrantel Pamoate	25
Prednisolone	107
Prednisolone + Trimeprazine Tartrate	29
Prednisone	371
Propofol	83
Pyrantel Pamoate	45
Pyrantel Pamoate + Sarolaner	146
Rabacfosadine	46
Robenacoxib	82
Sarolaner	82
Sarolaner + Selamectin	31
Selamectin	156
Sodium Chloride	29
Spinosad	213
Sucralfate	91
Tigilanol tiglate	36
Tramadol	133
Trazodone	50
Trilostane	159
Velagliflozin	103
Verdinexor	32
Vitamin E	37

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 110 ingredients.

Show the 110 ingredients

Reports by species

Dog83.9%5,946
Cat14.8%1,050
Horse1.2%82
Cattle0.1%9
Donkeyunder 0.1%1
Otherunder 0.1%1

The share is of the 7,090 reports that list this sign. The sign is in 0.6% of all reports about the species dog. The sign is in 0.7% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Neutrophilia, by the year in which FDA received them
Year	Reports
2026	335
2025	645
2024	560
2023	334
2022	256
2021	262
2020	293
2019	298
2018	390
2017	425
2016	381
2015	360
2014	286
2013	279
2012	311
2011	196
2010	137
2009	160
2008	169
2007	214
2006	131
2005	122
2004	156
2003	79
2002	47
2001	46
2000	63
1999	62
1998	46
1997	7
1996	1
1995	7
1994	2
1993	3
1992	1
1990	1
1989	7
1988	11
1987	7

What these reports record

Outcome at the time of the report

Reports with this sign
All reports

Recovered/Normal8.7%616, All reports: 20.7%
Recovered with Sequela[recovered, with a lasting effect]2%141, All reports: 2.3%
Ongoing29.1%2,065, All reports: 17.4%
Died15.5%1,102, All reports: 4.9%
Euthanized13.5%955, All reports: 1.5%
Outcome Unknown16.3%1,155, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 7,090 reports that list this sign.

Age of the animal

Reports with this sign
All reports

Under 1 year8.3%586, All reports: 9.5%
1 to 3 years17.9%1,272, All reports: 23.9%
4 to 7 years25%1,776, All reports: 20.2%
8 to 11 years28.6%2,025, All reports: 15.4%
12 years and over19.4%1,373, All reports: 10.7%
Age not given0.8%58, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

Neurological disorder NOS[NOS: not otherwise specified]
Neurological signs NOS[NOS: not otherwise specified]
Neurological symptoms NOS[NOS: not otherwise specified]
Neutropenia[low neutrophil count]
No sign[no clinical sign was reported]
Non-regenerative anaemia
Not drinking
Not eating

All clinical signs

Cite this page

Pet Drug Reports. Neutrophilia: adverse event reports for animal drugs. https://petdrugreports.com/reaction/neutrophilia/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?: In plain words: high neutrophil count. It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.
How does the count of the latest 12 months compare with the 12 months before?: FDA received 653 reports in the 12 months to June 2026. It received 615 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
How many of these reports have a serious flag?: Of the 5,383 reports that say if the event was serious, 79.2% have the serious flag. The person who sends a report sets the flag.
Does a drug in the table cause this sign?: The reports do not show that. A report can name more than one drug. FDA states this about the data.
When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices