Lung oedema: in adverse event reports for animal drugs

Clinical sign, a VeDDRA term

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarian How to report to FDA

From January 1987 to June 2026, FDA received 1,233 adverse event reports for animal drugs that list this sign. That is under 0.1% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 17 reports that list this sign.

Of the 1,233 reports, 54.1% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 416 of 1,149 clinical signs with a page. Fewer than 20 reports listed this sign in the 12 months before June 2026, so this page gives no change. Reports about cats are 34.9% of the reports that list this sign, and 11% of all reports.

Search engines list a sign page with 3,000 reports or more in all years. The page also needs 300 reports or more in the 12 months to June 2026. This page is under one of these numbers. The site keeps the page and keeps it out of search engines.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 21 drug pages.

Drug pages with 20 or more reports that list this sign, in order of name
Active ingredients	Reports that list the sign
Amoxicillin	27
Atipamezole Hydrochloride	21
Butorphanol Tartrate	27
Carprofen	88
Cefovecin sodium	51
Deracoxib	32
Dexmedetomidine hydrochloride	24
Ivermectin	21
Ketamine Hydrochloride	31
Medetomidine	86
Melarsomine Dihydrochloride	62
Meloxicam	35
Methylprednisolone Acetate	32
Milbemycin Oxime	21
Milbemycin Oxime + Spinosad	20
Monensin	21
Moxidectin	55
Pimobendan	25
Propofol	25
Selamectin	51
Tiletamine Hydrochloride + Zolazepam Hydrochloride	131

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 23 ingredients.

Reports by species

Dog54.1%667
Cat34.9%430
Cattle7.2%89
Horse1.6%20
Pig0.6%7
Human exposure0.5%6

The share is of the 1,233 reports that list this sign. The sign is in 0.1% of all reports about the species dog. The sign is in 0.3% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Lung oedema, by the year in which FDA received them
Year	Reports
2026	6
2025	15
2024	11
2023	13
2022	10
2021	13
2020	10
2019	13
2018	14
2017	10
2016	11
2015	16
2014	13
2013	32
2012	26
2011	90
2010	79
2009	52
2008	72
2007	64
2006	56
2005	67
2004	78
2003	67
2002	49
2001	49
2000	58
1999	58
1998	58
1997	28
1996	17
1995	18
1994	7
1993	11
1992	9
1991	7
1990	11
1989	7
1988	4
1987	4

What these reports record

Outcome at the time of the report

Reports with this sign
All reports

Recovered/Normal0.8%10, All reports: 20.7%
Recovered with Sequela[recovered, with a lasting effect]0.2%2, All reports: 2.3%
Ongoing1.5%18, All reports: 17.4%
Died57.5%709, All reports: 4.9%
Euthanized4%49, All reports: 1.5%
Outcome Unknown1.6%20, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 1,233 reports that list this sign.

Age of the animal

Reports with this sign
All reports

Under 1 year24.4%301, All reports: 9.5%
1 to 3 years15.2%188, All reports: 23.9%
4 to 7 years17.8%220, All reports: 20.2%
8 to 11 years17.4%214, All reports: 15.4%
12 years and over14.5%179, All reports: 10.7%
Age not given10.6%131, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

All clinical signs

Cite this page

Pet Drug Reports. Lung oedema: adverse event reports for animal drugs. https://petdrugreports.com/reaction/lung-oedema/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?: It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.
How does the count of the latest 12 months compare with the 12 months before?: FDA received 17 reports in the 12 months to June 2026. It received 12 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
How many of these reports have a serious flag?: Of the 173 reports that say if the event was serious, 97.7% have the serious flag. The person who sends a report sets the flag.
Does a drug in the table cause this sign?: The reports do not show that. A report can name more than one drug. FDA states this about the data.
When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices