Staggering: in adverse event reports for animal drugs

Clinical sign, a VeDDRA term

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

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From January 1987 to June 2026, FDA received 2,580 adverse event reports for animal drugs that list this sign. That is 0.2% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 60 reports that list this sign.

Of the 2,580 reports, 73.9% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 229 of 1,149 clinical signs with a page. Reports that list this sign fell by 25.0% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about cattle are 7.6% of the reports that list this sign, and 2.3% of all reports.

Search engines list a sign page with 3,000 reports or more in all years. The page also needs 300 reports or more in the 12 months to June 2026. This page is under one of these numbers. The site keeps the page and keeps it out of search engines.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 32 drug pages.

Show the 32 drug pages

Drug pages with 20 or more reports that list this sign, in order of name
Active ingredients	Reports that list the sign
(S) - methoprene	31
Afoxolaner	109
Bedinvetmab	57
Butorphanol Tartrate	20
Carprofen	235
Cefovecin sodium	44
Cyclosporine	24
Deracoxib	25
Doramectin	21
Firocoxib	58
Fluralaner	83
Gabapentin	23
Insulin	46
Ivermectin	280
Ivermectin + Praziquantel + Pyrantel Pamoate	25
Ivermectin + Pyrantel Pamoate	276
Lufenuron + Milbemycin Oxime	26
Maropitant	34
Melarsomine Dihydrochloride	51
Meloxicam	41
Milbemycin Oxime	42
Milbemycin Oxime + Praziquantel	25
Milbemycin Oxime + Spinosad	151
Monensin	23
Moxidectin	108
Praziquantel + Pyrantel Pamoate	25
Pyrantel Pamoate + Sarolaner	23
Sarolaner	28
Selamectin	68
Spinosad	136
Tiletamine Hydrochloride + Zolazepam Hydrochloride	23
Tilmicosin Phosphate	22

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 33 ingredients.

Show the 33 ingredients

Reports by species

Dog73.9%1,907
Cat13%335
Cattle7.6%197
Horse3.4%87
Sheep0.6%16
Pig0.6%15

The share is of the 2,580 reports that list this sign. The sign is in 0.2% of all reports about the species dog. The sign is in 0.2% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Staggering, by the year in which FDA received them
Year	Reports
2026	32
2025	67
2024	88
2023	59
2022	50
2021	51
2020	79
2019	94
2018	76
2017	82
2016	96
2015	112
2014	111
2013	115
2012	143
2011	79
2010	104
2009	150
2008	127
2007	83
2006	59
2005	63
2004	72
2003	70
2002	51
2001	43
2000	68
1999	47
1998	34
1997	18
1996	36
1995	19
1994	13
1993	9
1992	7
1991	7
1990	10
1989	82
1988	18
1987	56

What these reports record

Outcome at the time of the report

Reports with this sign
All reports

Recovered/Normal19%489, All reports: 20.7%
Recovered with Sequela[recovered, with a lasting effect]1.1%29, All reports: 2.3%
Ongoing9.7%250, All reports: 17.4%
Died19%490, All reports: 4.9%
Euthanized2.7%70, All reports: 1.5%
Outcome Unknown11.7%302, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 2,580 reports that list this sign.

Age of the animal

Reports with this sign
All reports

Under 1 year13.2%341, All reports: 9.5%
1 to 3 years19.5%503, All reports: 23.9%
4 to 7 years20.3%523, All reports: 20.2%
8 to 11 years18.7%483, All reports: 15.4%
12 years and over17.8%458, All reports: 10.7%
Age not given10.5%272, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

All clinical signs

Cite this page

Pet Drug Reports. Staggering: adverse event reports for animal drugs. https://petdrugreports.com/reaction/staggering/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?: It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.
How does the count of the latest 12 months compare with the 12 months before?: FDA received 60 reports in the 12 months to June 2026. It received 80 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
How many of these reports have a serious flag?: Of the 1,214 reports that say if the event was serious, 58% have the serious flag. The person who sends a report sets the flag.
Does a drug in the table cause this sign?: The reports do not show that. A report can name more than one drug. FDA states this about the data.
When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices