Pet Drug Reports

Elevated renal parametersin adverse event reports for animal drugs

Clinical sign, a VeDDRA term

In plain words: kidney values above the normal range.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarianHow to report to FDA

From August 1998 to June 2026, FDA received 2,412 adverse event reports for animal drugs that list this sign. That is 0.2% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 147 reports that list this sign.

Of the 2,412 reports, 76% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 237 of 1,149 clinical signs with a page. Reports that list this sign fell by 33.8% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about cats are 22.9% of the reports that list this sign, and 11% of all reports.

Search engines list a sign page with 3,000 reports or more in all years. The page also needs 300 reports or more in the 12 months to June 2026. This page is under one of these numbers. The site keeps the page and keeps it out of search engines.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 52 drug pages.

Show the 52 drug pages
Drug pages with 20 or more reports that list this sign, in order of name
Active ingredientsReports that list the sign
Afoxolaner41
Amoxicillin28
Amoxicillin Trihydrate + Clavulanate Potassium32
Bedinvetmab239
Bexagliflozin23
Buprenorphine52
Butorphanol Tartrate33
Capromorelin27
Carprofen514
Cefovecin sodium144
Cephalexin25
Cyclosporine31
Deracoxib90
Dexamethasone36
Dexmedetomidine hydrochloride22
Diphenhydramine27
Doxycycline45
Enalapril Maleate41
Enrofloxacin51
Famotidine92
Firocoxib77
Fluralaner56
Frunevetmab99
Furosemide28
Gabapentin115
Grapiprant103
Hydromorphone24
Imidacloprid + Moxidectin20
Isoflurane37
Ivermectin + Pyrantel Pamoate45
Ketamine Hydrochloride23
Maropitant252
Melarsomine Dihydrochloride21
Meloxicam181
Metronidazole42
Milbemycin Oxime + Praziquantel27
Milbemycin Oxime + Spinosad66
Mirtazapine31
Moxidectin87
Oclacitinib164
Pimobendan34
Prednisone47
Propofol24
Pyrantel Pamoate + Sarolaner35
Robenacoxib29
Sarolaner39
Selamectin44
Spinosad36
Sucralfate36
Tramadol68
Trilostane110
Vitamin E20

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 56 ingredients.

Show the 56 ingredients

Reports by species

The share is of the 2,412 reports that list this sign. The sign is in 0.2% of all reports about the species dog. The sign is in 0.4% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Elevated renal parameters, by the year in which FDA received them
YearReports
202662
2025188
2024269
2023105
202272
202160
202093
2019106
2018141
2017140
2016160
2015110
201487
2013159
2012142
201155
201038
200943
200857
200783
200657
200536
200424
200324
200221
200136
200025
199915
19984

What these reports record

Outcome at the time of the report

  • Reports with this sign
  • All reports
  • Recovered/Normal5.9%142
  • Recovered with Sequela[recovered, with a lasting effect]1.1%26
  • Ongoing34.3%828
  • Died15.2%366
  • Euthanized16.7%404
  • Outcome Unknown13.8%334

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 2,412 reports that list this sign.

Age of the animal

  • Reports with this sign
  • All reports
  • Under 1 year3.6%87
  • 1 to 3 years9.5%229
  • 4 to 7 years17.7%426
  • 8 to 11 years26.2%631
  • 12 years and over40.2%970
  • Age not given2.9%69

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

All clinical signs

Cite this page

Pet Drug Reports. Elevated renal parameters: adverse event reports for animal drugs. https://petdrugreports.com/reaction/elevated-renal-parameters/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?

In plain words: kidney values above the normal range. It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.

How does the count of the latest 12 months compare with the 12 months before?

FDA received 147 reports in the 12 months to June 2026. It received 222 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

How many of these reports have a serious flag?

Of the 1,883 reports that say if the event was serious, 70.5% have the serious flag. The person who sends a report sets the flag.

Does a drug in the table cause this sign?

The reports do not show that. A report can name more than one drug. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices