Pet Drug Reports

Leucocytosis NOS: in adverse event reports for animal drugs

Clinical sign, a VeDDRA term

In plain words: high white blood cell count.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarianHow to report to FDA

From January 1987 to March 2026, FDA received 11,921 adverse event reports for animal drugs that list this sign. That is 0.9% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 270 reports that list this sign.

Of the 11,921 reports, 87.2% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 48 of 1,149 clinical signs with a page. Reports that list this sign fell by 57.2% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 87.2% of the reports that list this sign, and 72.6% of all reports.

Search engines list a sign page with 3,000 reports or more in all years. The page also needs 300 reports or more in the 12 months to June 2026. This page is under one of these numbers. The site keeps the page and keeps it out of search engines.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 127 drug pages.

Show the 127 drug pages
Drug pages with 20 or more reports that list this sign, in order of name
Active ingredientsReports that list the sign
(S) - methoprene25
Acepromazine Maleate59
Afoxolaner414
Afoxolaner + Moxidectin + Pyrantel Pamoate39
Amoxicillin239
Amoxicillin + Clavulanate Potassium125
Amoxicillin Trihydrate + Clavulanate Potassium143
Ampicillin Sodium49
Atipamezole Hydrochloride54
Atropine39
Bedinvetmab364
Bexagliflozin66
Buprenorphine171
Butorphanol Tartrate158
Capromorelin79
Carprofen2,606
Cefovecin sodium455
Cefpodoxime proxetil136
Ceftiofur Crystalline Free Acid20
Cephalexin74
Ciprofloxacin21
Clindamycin67
Clomipramine Hydrochloride24
Cyclosporine309
Deracoxib781
Desoxycorticosterone Pivalate56
Dexamethasone200
Dexamethasone Sodium Phosphate76
Dexmedetomidine60
Dexmedetomidine hydrochloride65
Dextrose46
Diazepam46
Diphenhydramine174
Dirlotapide53
Doxycycline223
Emodepside + Praziquantel28
Enalapril Maleate27
Enrofloxacin249
Eprinomectin + Esafoxolaner + Praziquantel37
Estriol22
Etodolac73
Famotidine207
Febantel + Praziquantel + Pyrantel Pamoate29
Fenbendazole40
Fentanyl23
Firocoxib342
Florfenicol + Mometasone furoate + Terbinafine35
Florfenicol + Terbinafine21
Fluralaner544
Fluralaner + Moxidectin21
Frunevetmab70
Furosemide71
Gabapentin298
Grapiprant122
Hydromorphone57
Hydroxyzine21
Ilunocitinib24
Imidacloprid48
Imidacloprid + Moxidectin84
Insulin124
Isoflurane107
Ivermectin154
Ivermectin + Praziquantel + Pyrantel Pamoate21
Ivermectin + Pyrantel Pamoate393
Ketamine Hydrochloride66
Ketoconazole36
Ketoprofen33
Levothyroxine sodium47
Lotilaner69
Lufenuron47
Lufenuron + Milbemycin Oxime110
Lufenuron + Milbemycin Oxime + Praziquantel22
Marbofloxacin84
Maropitant841
Medetomidine31
Melarsomine Dihydrochloride456
Meloxicam391
Methocarbamol31
Methylprednisolone Acetate73
Metoclopramide66
Metronidazole206
Midazolam59
Milbemycin Oxime139
Milbemycin Oxime + Praziquantel136
Milbemycin Oxime + Spinosad463
Mirtazapine69
Moxidectin794
Mycophenolate23
Nitenpyram70
Oclacitinib363
Omeprazole75
Ondansetron73
Orbifloxacin23
Ormetoprim + Sulfadimethoxine39
Oxibendazole49
Phenobarbital28
Pimobendan50
Polysulfated Glycosaminoglycan78
Praziquantel + Pyrantel Pamoate26
Prednisolone96
Prednisolone + Trimeprazine Tartrate52
Prednisone405
Propofol98
Pyrantel Pamoate78
Pyrantel Pamoate + Sarolaner173
Rabacfosadine28
Robenacoxib67
Sarolaner112
Sarolaner + Selamectin28
Selamectin352
Selegiline Hydrochloride55
Sevoflurane25
Sodium Chloride22
Spinosad253
Sucralfate140
Sulfadimethoxine34
Tigilanol tiglate34
Tiletamine Hydrochloride + Zolazepam Hydrochloride24
Toceranib Phosphate28
Tramadol163
Trazodone48
Triamcinolone Acetonide24
Trilostane190
Ursodiol29
Velagliflozin61
Verdinexor29
Vitamin E58

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 123 ingredients.

Show the 123 ingredients

Reports by species

The share is of the 11,921 reports that list this sign. The sign is in 1% of all reports about the species dog. The sign is in 0.9% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Leucocytosis NOS, by the year in which FDA received them
YearReports
20264
2025554
2024668
2023412
2022302
2021335
2020355
2019426
2018478
2017540
2016587
2015512
2014444
2013423
2012405
2011475
2010420
2009404
2008400
2007474
2006446
2005465
2004660
2003395
2002256
2001214
2000247
1999195
1998216
199762
199625
199524
19945
19933
19926
19914
19903
198915
198831
198731

What these reports record

Outcome at the time of the report

  • Reports with this sign
  • All reports
  • Recovered/Normal5.9%706, All reports: 20.7%
  • Recovered with Sequela[recovered, with a lasting effect]1.2%138, All reports: 2.3%
  • Ongoing20.8%2,481, All reports: 17.4%
  • Died23.4%2,795, All reports: 4.9%
  • Euthanized10%1,195, All reports: 1.5%
  • Outcome Unknown10.4%1,236, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 11,921 reports that list this sign.

Age of the animal

  • Reports with this sign
  • All reports
  • Under 1 year8.4%1,002, All reports: 9.5%
  • 1 to 3 years16.5%1,968, All reports: 23.9%
  • 4 to 7 years25%2,977, All reports: 20.2%
  • 8 to 11 years30.5%3,639, All reports: 15.4%
  • 12 years and over18.3%2,187, All reports: 10.7%
  • Age not given1.2%148, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

All clinical signs

Cite this page

Pet Drug Reports. Leucocytosis NOS: adverse event reports for animal drugs. https://petdrugreports.com/reaction/leucocytosis-nos/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?

In plain words: high white blood cell count. It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.

How does the count of the latest 12 months compare with the 12 months before?

FDA received 270 reports in the 12 months to June 2026. It received 631 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

How many of these reports have a serious flag?

Of the 6,340 reports that say if the event was serious, 79.4% have the serious flag. The person who sends a report sets the flag.

Does a drug in the table cause this sign?

The reports do not show that. A report can name more than one drug. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices