Pet Drug Reports

Elevated liver enzymes: in adverse event reports for animal drugs

Clinical sign, a VeDDRA term

In plain words: liver enzymes above the normal range.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarianHow to report to FDA

From February 1987 to April 2024, FDA received 8,230 adverse event reports for animal drugs that list this sign. That is 0.6% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received no reports that list this sign.

Of the 8,230 reports, 92.8% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 81 of 1,149 clinical signs with a page. Fewer than 20 reports listed this sign in the 12 months before June 2026, so this page gives no change. Reports about dogs are 92.8% of the reports that list this sign, and 72.6% of all reports.

Search engines list a sign page with 3,000 reports or more in all years. The page also needs 300 reports or more in the 12 months to June 2026. This page is under one of these numbers. The site keeps the page and keeps it out of search engines.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 92 drug pages.

Show the 92 drug pages
Drug pages with 20 or more reports that list this sign, in order of name
Active ingredientsReports that list the sign
(S) - methoprene33
Acepromazine Maleate39
Acetylsalicylic Acid20
Afoxolaner211
Amoxicillin110
Amoxicillin + Clavulanate Potassium43
Amoxicillin Trihydrate + Clavulanate Potassium66
Ampicillin Sodium27
Atipamezole Hydrochloride26
Buprenorphine70
Butorphanol Tartrate81
Capromorelin21
Carprofen2,483
Cefovecin sodium166
Cefpodoxime proxetil95
Cephalexin60
Clindamycin31
Clomipramine Hydrochloride31
Cyclosporine148
Deracoxib246
Dexamethasone78
Dexamethasone Sodium Phosphate22
Dexmedetomidine hydrochloride41
Diazepam34
Diphenhydramine103
Dirlotapide23
Doxycycline111
Enalapril Maleate39
Enrofloxacin140
Etodolac127
Famotidine176
Fenbendazole20
Firocoxib179
Fluralaner165
Furosemide37
Gabapentin131
Grapiprant215
Hydromorphone39
Imidacloprid26
Imidacloprid + Moxidectin93
Insulin59
Isoflurane67
Itraconazole41
Ivermectin105
Ivermectin + Praziquantel + Pyrantel Pamoate51
Ivermectin + Pyrantel Pamoate295
Ketamine Hydrochloride35
Ketoconazole21
Levothyroxine sodium54
Lotilaner30
Lufenuron + Milbemycin Oxime98
Marbofloxacin30
Maropitant411
Melarsomine Dihydrochloride202
Meloxicam206
Methocarbamol23
Metoclopramide45
Metronidazole139
Midazolam25
Milbemycin Oxime90
Milbemycin Oxime + Praziquantel123
Milbemycin Oxime + Spinosad672
Mirtazapine28
Moxidectin335
Nitenpyram29
Oclacitinib521
Omeprazole46
Ondansetron30
Ormetoprim + Sulfadimethoxine27
Oxibendazole55
Phenobarbital25
Pimobendan46
Polysulfated Glycosaminoglycan75
Prednisolone50
Prednisolone + Trimeprazine Tartrate56
Prednisone187
Propofol52
Pyrantel Pamoate27
Pyrantel Pamoate + Sarolaner85
Rabacfosadine49
Robenacoxib20
Sarolaner101
Selamectin182
Selegiline Hydrochloride40
Spinosad280
Sucralfate93
Tepoxalin24
Toceranib Phosphate37
Tramadol220
Trilostane267
Ursodiol45
Vitamin E133

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 97 ingredients.

Show the 97 ingredients

Reports by species

The share is of the 8,230 reports that list this sign. The sign is in 0.8% of all reports about the species dog. The sign is in 0.3% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Elevated liver enzymes, by the year in which FDA received them
YearReports
20241
2023273
2022226
2021255
2020315
2019417
2018499
2017495
2016501
2015539
2014525
2013635
2012596
2011276
2010193
2009211
2008193
2007175
2006157
2005157
2004191
2003124
2002185
2001160
2000267
1999221
1998228
1997108
199617
199520
199415
19937
19927
19917
19909
19892
19889
198714

What these reports record

Outcome at the time of the report

  • Reports with this sign
  • All reports
  • Recovered/Normal7.2%594, All reports: 20.7%
  • Recovered with Sequela[recovered, with a lasting effect]2.7%226, All reports: 2.3%
  • Ongoing26.8%2,203, All reports: 17.4%
  • Died13.8%1,133, All reports: 4.9%
  • Euthanized7.6%625, All reports: 1.5%
  • Outcome Unknown16.3%1,338, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 8,230 reports that list this sign.

Age of the animal

  • Reports with this sign
  • All reports
  • Under 1 year3.5%288, All reports: 9.5%
  • 1 to 3 years11.6%956, All reports: 23.9%
  • 4 to 7 years23.1%1,901, All reports: 20.2%
  • 8 to 11 years33.4%2,749, All reports: 15.4%
  • 12 years and over23.4%1,929, All reports: 10.7%
  • Age not given4.9%407, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

All clinical signs

Cite this page

Pet Drug Reports. Elevated liver enzymes: adverse event reports for animal drugs. https://petdrugreports.com/reaction/elevated-liver-enzymes/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?

In plain words: liver enzymes above the normal range. It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.

How does the count of the latest 12 months compare with the 12 months before?

FDA received no reports in the 12 months to June 2026. It received no reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

How many of these reports have a serious flag?

Of the 5,266 reports that say if the event was serious, 59.3% have the serious flag. The person who sends a report sets the flag.

Does a drug in the table cause this sign?

The reports do not show that. A report can name more than one drug. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices