Polydipsia: in adverse event reports for animal drugs

Clinical sign, a VeDDRA term

In plain words: drinking more than usual.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarian How to report to FDA

From February 1987 to June 2026, FDA received 14,441 adverse event reports for animal drugs that list this sign. That is 1.1% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 785 reports that list this sign.

Of the 14,441 reports, 89.4% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 38 of 1,149 clinical signs with a page. Reports that list this sign fell by 31.4% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 89.4% of the reports that list this sign, and 72.6% of all reports.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 122 drug pages.

Show the 122 drug pages

Drug pages with 20 or more reports that list this sign, in order of name
Active ingredients	Reports that list the sign
(S) - methoprene	35
Acepromazine Maleate	33
Afoxolaner	349
Afoxolaner + Moxidectin + Pyrantel Pamoate	22
Amantadine	42
Amlodipine	22
Amoxicillin	151
Amoxicillin + Clavulanate Potassium	63
Amoxicillin Trihydrate + Clavulanate Potassium	95
Atipamezole Hydrochloride	28
Bedinvetmab	1,687
Benazepril	25
Bexagliflozin	214
Buprenorphine	46
Butorphanol Tartrate	75
Capromorelin	61
Carprofen	2,346
Cefovecin sodium	202
Cefpodoxime proxetil	172
Cephalexin	59
Clindamycin	30
Clodronate	63
Clomipramine Hydrochloride	65
Clotrimazole + Gentamicin Sulfate + Mometasone Furoate Monohydrate	20
Cyclosporine	517
Deracoxib	665
Desoxycorticosterone Pivalate	303
Dexamethasone	74
Dexamethasone + Neomycin Sulfate + Thiabendazole	20
Dexamethasone + Thiabendazole	20
Dexamethasone Sodium Phosphate	30
Dexmedetomidine	35
Dexmedetomidine hydrochloride	25
Diazepam	22
Diphenhydramine	82
Dirlotapide	81
Doxycycline	89
Enalapril Maleate	68
Enrofloxacin	106
Estriol	74
Etodolac	78
Famotidine	101
Febantel + Praziquantel + Pyrantel Pamoate	55
Fenbendazole	44
Firocoxib	355
Florfenicol + Mometasone furoate + Terbinafine	35
Florfenicol + Terbinafine	25
Flunixin Meglumine	21
Fluoxetine hydrochloride	50
Fluralaner	554
Frunevetmab	126
Furosemide	46
Gabapentin	450
Grapiprant	193
Hydroxyzine	31
Ilunocitinib	53
Imidacloprid	41
Imidacloprid + Moxidectin	143
Insulin	668
Isoflupredone Acetate + Neomycin Sulfate + Tetracaine Hydrochloride	20
Isoflurane	44
Ivermectin	115
Ivermectin + Praziquantel + Pyrantel Pamoate	21
Ivermectin + Pyrantel Pamoate	346
Ketamine Hydrochloride	27
Ketoconazole	57
Ketoprofen	29
Levothyroxine sodium	162
Lotilaner	85
Lufenuron	30
Lufenuron + Milbemycin Oxime	122
Marbofloxacin	54
Maropitant	350
Melarsomine Dihydrochloride	173
Melatonin	21
Meloxicam	420
Methocarbamol	25
Methylprednisolone Acetate	91
Metronidazole	106
Midazolam	27
Milbemycin Oxime	143
Milbemycin Oxime + Praziquantel	93
Milbemycin Oxime + Spinosad	356
Mirtazapine	31
Monensin	21
Moxidectin	350
Nitenpyram	49
Oclacitinib	761
Omeprazole	56
Ondansetron	31
Orbifloxacin	21
Ormetoprim + Sulfadimethoxine	30
Oxibendazole	43
Phenobarbital	31
Phenylpropanolamine hydrochloride	27
Pimobendan	134
Polysulfated Glycosaminoglycan	90
Praziquantel + Pyrantel Pamoate	25
Prednisolone	95
Prednisolone + Trimeprazine Tartrate	119
Prednisone	463
Primidone	29
Propofol	29
Pyrantel Pamoate	43
Pyrantel Pamoate + Sarolaner	267
Rabacfosadine	20
Sarolaner	83
Selamectin	248
Selegiline Hydrochloride	190
Spinosad	327
Sucralfate	37
Telmisartan	20
Tepoxalin	27
Tigilanol tiglate	40
Tramadol	161
Trazodone	43
Triamcinolone Acetonide	36
Trilostane	861
Ursodiol	53
Velagliflozin	155
Verdinexor	30
Vitamin E	43

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 125 ingredients.

Show the 125 ingredients

Reports by species

Dog89.4%12,904
Cat9.4%1,363
Horse0.9%124
Cattle0.1%17
Turkeyunder 0.1%6
Otherunder 0.1%5

The share is of the 14,441 reports that list this sign. The sign is in 1.3% of all reports about the species dog. The sign is in 0.9% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Polydipsia, by the year in which FDA received them
Year	Reports
2026	348
2025	1,002
2024	1,357
2023	466
2022	309
2021	329
2020	406
2019	422
2018	492
2017	546
2016	674
2015	699
2014	614
2013	511
2012	577
2011	464
2010	632
2009	761
2008	500
2007	522
2006	417
2005	436
2004	398
2003	256
2002	154
2001	164
2000	305
1999	280
1998	188
1997	73
1996	27
1995	15
1994	20
1993	5
1992	4
1991	11
1990	9
1989	6
1988	27
1987	15

What these reports record

Outcome at the time of the report

Reports with this sign
All reports

Recovered/Normal9.1%1,319, All reports: 20.7%
Recovered with Sequela[recovered, with a lasting effect]1.5%215, All reports: 2.3%
Ongoing25.8%3,721, All reports: 17.4%
Died8.9%1,281, All reports: 4.9%
Euthanized4.6%669, All reports: 1.5%
Outcome Unknown17.3%2,504, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 14,441 reports that list this sign.

Age of the animal

Reports with this sign
All reports

Under 1 year4.3%621, All reports: 9.5%
1 to 3 years10%1,445, All reports: 23.9%
4 to 7 years21.1%3,041, All reports: 20.2%
8 to 11 years33.8%4,878, All reports: 15.4%
12 years and over27.8%4,020, All reports: 10.7%
Age not given3%436, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

All clinical signs

Cite this page

Pet Drug Reports. Polydipsia: adverse event reports for animal drugs. https://petdrugreports.com/reaction/polydipsia/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?: In plain words: drinking more than usual. It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.
How does the count of the latest 12 months compare with the 12 months before?: FDA received 785 reports in the 12 months to June 2026. It received 1,144 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
How many of these reports have a serious flag?: Of the 8,559 reports that say if the event was serious, 55.2% have the serious flag. The person who sends a report sets the flag.
Does a drug in the table cause this sign?: The reports do not show that. A report can name more than one drug. FDA states this about the data.
When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices