Inappropriate urination: in adverse event reports for animal drugs

Clinical sign, a VeDDRA term

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarian How to report to FDA

From May 2003 to June 2026, FDA received 5,825 adverse event reports for animal drugs that list this sign. That is 0.4% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 519 reports that list this sign.

Of the 5,825 reports, 82.2% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 110 of 1,149 clinical signs with a page. Reports that list this sign fell by 32.1% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 82.2% of the reports that list this sign, and 72.6% of all reports.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 90 drug pages.

Show the 90 drug pages

Drug pages with 20 or more reports that list this sign, in order of name
Active ingredients	Reports that list the sign
(S) - methoprene	33
Acepromazine Maleate	24
Afoxolaner	473
Afoxolaner + Moxidectin + Pyrantel Pamoate	39
Amlodipine	24
Amoxicillin	48
Amoxicillin + Clavulanate Potassium	38
Amoxicillin Trihydrate + Clavulanate Potassium	54
Atipamezole Hydrochloride	30
Bedinvetmab	744
Bexagliflozin	105
Buprenorphine	104
Butorphanol Tartrate	57
Capromorelin	35
Carprofen	265
Cefovecin sodium	176
Cefpodoxime proxetil	58
Cephalexin	26
Clindamycin	25
Cyclosporine	105
Deracoxib	50
Desoxycorticosterone Pivalate	31
Dexamethasone	64
Dexamethasone Sodium Phosphate	22
Dexmedetomidine	24
Dexmedetomidine hydrochloride	28
Diazepam	20
Diphenhydramine	79
Doxycycline	53
Emodepside + Praziquantel	28
Enalapril Maleate	23
Enrofloxacin	64
Eprinomectin + Esafoxolaner + Praziquantel	22
Famotidine	58
Febantel + Praziquantel + Pyrantel Pamoate	32
Firocoxib	44
Florfenicol + Mometasone furoate + Terbinafine	55
Fluoxetine hydrochloride	34
Fluralaner	538
Frunevetmab	159
Furosemide	22
Gabapentin	256
Grapiprant	105
Ilunocitinib	31
Imidacloprid	40
Imidacloprid + Moxidectin	113
Insulin	99
Isoflurane	51
Ivermectin	63
Ivermectin + Praziquantel + Pyrantel Pamoate	20
Ivermectin + Pyrantel Pamoate	352
Ketamine Hydrochloride	20
Ketoconazole	24
Levothyroxine sodium	50
Lotilaner	102
Lufenuron + Milbemycin Oxime	59
Maropitant	211
Melarsomine Dihydrochloride	86
Meloxicam	85
Methimazole	22
Metronidazole	46
Midazolam	31
Milbemycin Oxime	36
Milbemycin Oxime + Praziquantel	124
Milbemycin Oxime + Spinosad	496
Mirtazapine	36
Moxidectin	168
Nitenpyram	80
Oclacitinib	289
Omeprazole	30
Ondansetron	25
Phenobarbital	24
Pimobendan	58
Polysulfated Glycosaminoglycan	50
Praziquantel + Pyrantel Pamoate	30
Prednisolone	62
Prednisolone + Trimeprazine Tartrate	25
Prednisone	189
Propofol	36
Pyrantel Pamoate	26
Pyrantel Pamoate + Sarolaner	247
Robenacoxib	53
Sarolaner	83
Sarolaner + Selamectin	39
Selamectin	92
Spinosad	160
Tramadol	80
Trazodone	35
Trilostane	406
Velagliflozin	95

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 86 ingredients.

Show the 86 ingredients

Reports by species

Dog82.2%4,789
Cat17.7%1,029
Horseunder 0.1%2
Cattleunder 0.1%1
Crustaceaunder 0.1%1
Rabbitunder 0.1%1

The share is of the 5,825 reports that list this sign. The sign is in 0.5% of all reports about the species dog. The sign is in 0.7% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Inappropriate urination, by the year in which FDA received them
Year	Reports
2026	222
2025	623
2024	822
2023	425
2022	286
2021	373
2020	367
2019	369
2018	339
2017	376
2016	386
2015	353
2014	311
2013	276
2012	214
2011	59
2010	5
2009	2
2008	9
2007	1
2006	2
2005	2
2004	1
2003	2

What these reports record

Outcome at the time of the report

Reports with this sign
All reports

Recovered/Normal23.7%1,380, All reports: 20.7%
Recovered with Sequela[recovered, with a lasting effect]2.8%163, All reports: 2.3%
Ongoing32.4%1,888, All reports: 17.4%
Died5.4%312, All reports: 4.9%
Euthanized7.9%460, All reports: 1.5%
Outcome Unknown27.8%1,622, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 5,825 reports that list this sign.

Age of the animal

Reports with this sign
All reports

Under 1 year10.2%595, All reports: 9.5%
1 to 3 years16.9%985, All reports: 23.9%
4 to 7 years19.6%1,139, All reports: 20.2%
8 to 11 years23.9%1,391, All reports: 15.4%
12 years and over27.2%1,582, All reports: 10.7%
Age not given2.3%133, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

Inappropriate defecation
Inappropriate elimination NOS[NOS: not otherwise specified]
Inappropriate preparation of medication
Inappropriate schedule of drug administration
Incoordination
Incorrect dose administered NOS[NOS: not otherwise specified]
Incorrect route of drug administration
Incorrect storage of drug

All clinical signs

Cite this page

Pet Drug Reports. Inappropriate urination: adverse event reports for animal drugs. https://petdrugreports.com/reaction/inappropriate-urination/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?: It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.
How does the count of the latest 12 months compare with the 12 months before?: FDA received 519 reports in the 12 months to June 2026. It received 764 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
How many of these reports have a serious flag?: Of the 5,778 reports that say if the event was serious, 56.8% have the serious flag. The person who sends a report sets the flag.
Does a drug in the table cause this sign?: The reports do not show that. A report can name more than one drug. FDA states this about the data.
When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices