Pet Drug Reports

Cyanosisin adverse event reports for animal drugs

Clinical sign, a VeDDRA term

In plain words: bluish gums or skin from low oxygen.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarianHow to report to FDA

From January 1987 to June 2026, FDA received 2,320 adverse event reports for animal drugs that list this sign. That is 0.2% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 82 reports that list this sign.

Of the 2,320 reports, 68.9% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 249 of 1,149 clinical signs with a page. Reports that list this sign fell by 9.9% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about cats are 25.8% of the reports that list this sign, and 11% of all reports.

Search engines list a sign page with 3,000 reports or more in all years. The page also needs 300 reports or more in the 12 months to June 2026. This page is under one of these numbers. The site keeps the page and keeps it out of search engines.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 48 drug pages.

Show the 48 drug pages
Drug pages with 20 or more reports that list this sign, in order of name
Active ingredientsReports that list the sign
Acepromazine Maleate55
Afoxolaner37
Alfaxalone46
Amoxicillin23
Atipamezole Hydrochloride78
Atropine39
Bedinvetmab26
Buprenorphine67
Butorphanol Tartrate169
Carprofen129
Cefovecin sodium106
Cyclosporine32
Deracoxib36
Dexamethasone51
Dexmedetomidine41
Dexmedetomidine hydrochloride129
Diphenhydramine62
Famotidine21
Fluralaner40
Furosemide35
Gabapentin32
Hydromorphone26
Isoflurane107
Ivermectin36
Ivermectin + Pyrantel Pamoate45
Ketamine Hydrochloride153
Lufenuron + Milbemycin Oxime23
Maropitant123
Medetomidine82
Melarsomine Dihydrochloride188
Meloxicam48
Methylprednisolone Acetate24
Midazolam55
Milbemycin Oxime34
Milbemycin Oxime + Spinosad50
Moxidectin209
Nitenpyram24
Oclacitinib35
Pimobendan31
Prednisone37
Propofol154
Robenacoxib25
Selamectin51
Sevoflurane46
Spinosad37
Tiletamine Hydrochloride24
Tiletamine Hydrochloride + Zolazepam Hydrochloride109
Triamcinolone Acetonide22

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 51 ingredients.

Show the 51 ingredients

Reports by species

The share is of the 2,320 reports that list this sign. The sign is in 0.2% of all reports about the species dog. The sign is in 0.4% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Cyanosis, by the year in which FDA received them
YearReports
202639
202592
202478
202375
202276
202197
202090
201989
201876
201766
201671
201567
201471
201368
2012105
201197
2010109
200992
200897
200761
200677
200582
200475
200367
200260
200156
200039
199935
199847
199745
199618
199517
199413
19937
19925
19917
19909
198921
19889
198715

What these reports record

Outcome at the time of the report

  • Reports with this sign
  • All reports
  • Recovered/Normal12.2%284
  • Recovered with Sequela[recovered, with a lasting effect]0.7%16
  • Ongoing9.4%219
  • Died43.4%1,007
  • Euthanized7.4%171
  • Outcome Unknown4%93

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 2,320 reports that list this sign.

Age of the animal

  • Reports with this sign
  • All reports
  • Under 1 year15.3%354
  • 1 to 3 years23.3%541
  • 4 to 7 years22.7%527
  • 8 to 11 years19.7%456
  • 12 years and over12.3%286
  • Age not given6.7%156

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

All clinical signs

Cite this page

Pet Drug Reports. Cyanosis: adverse event reports for animal drugs. https://petdrugreports.com/reaction/cyanosis/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?

In plain words: bluish gums or skin from low oxygen. It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.

How does the count of the latest 12 months compare with the 12 months before?

FDA received 82 reports in the 12 months to June 2026. It received 91 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

How many of these reports have a serious flag?

Of the 1,106 reports that say if the event was serious, 93.9% have the serious flag. The person who sends a report sets the flag.

Does a drug in the table cause this sign?

The reports do not show that. A report can name more than one drug. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices