Pet Drug Reports

Estradiol + Trenbolone Acetate (Revalor-G, Revalor-IS): adverse event reports that FDA received

Combination of 2 active ingredients

Also sold as: Revalor-G, Revalor-IS, Revalor-S, Revalor-200, Revalor-H, Revalor-IH, and 4 more brand names.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarianHow to report to FDA

From January 1995 to December 2025, FDA received 267 adverse event reports that name a drug with estradiol and trenbolone acetate as its active ingredients. Of the 267 reports, 163 (61%) are about cattle. 4 reports are about people who were exposed to the drug (1.5%).

In January to March 2026, FDA received no reports that name this drug. The signs that appear in the largest number of the 267 reports are "Death", "Increased sexual interest" and "Underfilling, Package". A report is not proof that a drug caused a sign.

Fewer than 20 reports named this drug in the 12 months before June 2026, so this page gives no change. Reports about cattle are 61% of the reports that name this drug, and 2.3% of all reports.

Search engines list a drug page with 500 reports or more in all years. The page also needs 30 reports or more in the 12 months to June 2026. This page is under one of these numbers. The site keeps the page and keeps it out of search engines.

Since the last update of the FDA data

The latest update of the FDA data, recorded on , changed no count of this page.

January to March 2026 is the latest closed quarter in the data. In that quarter FDA received 0 reports that name estradiol + trenbolone acetate: 0 dog, 0 cat, 0 horse, 0 other or not given.

All updatesFeed of updates (RSS)

Signs that the reports list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 267 reports that list the sign. One report can list more than one sign.

The sign that is in the largest number of the reports comes first.

  1. Death22.5%60 reports
  2. Underfilling, Package[a product quality report, not a sign in an animal]11.2%30 reports
  3. Implant, Abnormal10.9%29 reports
  4. Color, Abnormal[a product quality report, not a sign in an animal]10.1%27 reports
  5. Anaphylaxis[sudden severe allergic-type reaction]7.5%20 reports
  6. Respiratory tract disorder NOS[NOS: not otherwise specified]7.5%20 reports
  7. Dispenser, Abnormal[a product quality report, not a sign in an animal]6.7%18 reports
  8. Behavioural disorder NOS[behaviour change, type not specified]5.6%15 reports
  9. Digestive tract disorder NOS[digestive problem, type not specified]5.2%14 reports
  10. Lack of efficacy - NOS[the product did not have the expected effect]5.2%14 reports
  11. Pneumonia[lung infection or inflammation]4.5%12 reports
  12. Death by euthanasia[the animal was euthanized]3.4%9 reports
  13. Dyspnoea[difficulty breathing]3.4%9 reports
Show the next 16 signs
  1. Lameness3%8 reports
  2. Bronchopneumonia2.6%7 reports
  3. Facial oedema[swollen face]2.6%7 reports
  4. Found dead2.6%7 reports
  5. Lung oedema2.6%7 reports
  6. Ruminal bloat2.6%7 reports
  7. Bloated2.2%6 reports
  8. Trauma NOS[NOS: not otherwise specified]2.2%6 reports
  9. Caps, Abnormal[a product quality report, not a sign in an animal]1.9%5 reports
  10. Containers, Abnormal[a product quality report, not a sign in an animal]1.9%5 reports
  11. Ineffective, weight inc[legacy FDA term: the product did not have the expected effect (weight inc)]1.9%5 reports
  12. Injection site abscess[abscess where the injection was given]1.9%5 reports
  13. Liver abscess1.9%5 reports
  14. Product Defect, General[a product quality report, not a sign in an animal]1.9%5 reports
  15. Recumbency[lying down and unable or unwilling to rise]1.9%5 reports

The list shows 30 of 152 coded signs. A report is not proof that a drug caused a sign. Download all signs (CSV)

Reports by species

  • Cattle61%163
  • Human exposure1.5%4
  • Dog0.4%1
  • Other0.4%1

The share is of all 267 reports that name estradiol + trenbolone acetate. The other reports give a different species or no species.

Reports for each month, Jul 2021 to Jun 2026

Dog0 reports

No chart: no month has 5 or more reports.

Cat0 reports

No chart: no month has 5 or more reports.

Horse0 reports

No chart: no month has 5 or more reports.

Other or not given22 reports. Largest count in one month: 8 (Aug 2025)

The month is the month in which FDA received the report. Each chart has its own scale. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports by year

  • Dog
  • Cat
  • Horse
  • Other or not given
Reports that name estradiol + trenbolone acetate, by the year in which FDA received them and by species
YearDogCatHorseOther or not givenAll species
20250001616
202400022
202300022
202200011
202100011
202000055
201900044
201800033
201700066
201600044
201500055
20141001213
20130003232
20120003737
20110003434
20100002626
200900033
200800055
200700099
200600077
200500022
200400044
20030001313
200200055
200100033
200000055
199900011
199800033
199700099
199600033
199500044

2025 has the reports that FDA received through Dec 2025. Download the years (CSV)

What the reports record

Outcome at the time of the report

  • Recovered/Normal2.2%6
  • Recovered with Sequela[recovered, with a lasting effect]0.4%1
  • Ongoing1.9%5
  • Died27%72
  • Euthanized2.6%7
  • Outcome Unknown10.9%29

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 267 reports that name estradiol + trenbolone acetate.

A report about more than one animal can have more than one outcome.

Kind of report

  • Safety issue56.9%152
  • Lack of expected effectiveness4.5%12
  • Both safety and lack of expected effectiveness1.9%5
  • Manufacturing or product defect36.7%98
  • Other0%0

55 reports say if the event was serious. 69.1% of them have the serious flag. The person who sends the report sets the flag.

Show age, weight, breed and route

Age of the animal

  • Under 1 year13.5%36
  • 1 to 3 years16.1%43
  • 4 to 7 years0%0
  • 8 to 11 years0%0
  • 12 years and over1.1%3
  • Age not given69.3%185

Weight of the animal

  • Under 5 kg (11 lb)0%0
  • 5 to 9.9 kg (11 to 22 lb)0.4%1
  • 10 to 24.9 kg (22 to 55 lb)0%0
  • 25 to 44.9 kg (55 to 99 lb)0%0
  • 45 kg and over (99 lb and over)41.9%112
  • Weight not given57.7%154

Breed, where the report gives one breed

A breed with many animals has many reports.

Route in the report

  • Subcutaneous32.2%86
  • Other4.9%13
  • Topical1.9%5
  • Intramuscular0.7%2
  • Oral0.7%2
  • Parenteral0.4%1

Each bar is on a scale of 0 to 100%.

Approved animal drugs with these active ingredients (FDA Green Book)

This section is reference data. It has no report count.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Brand names

  • Revalor-G
  • Revalor-IS
  • Revalor-S
  • Revalor-200
  • Revalor-H
  • Revalor-IH
  • Revalor-XH
  • Revalor-XS
  • Revalor-XR
  • Synovex

What the Green Book records give

Applications with an approval in force
5
Approved species
Cattle
Dose forms
Implant, Implant (Pellet), Extended-release implant, Extended- and delayed-release implant
Routes
Subcutaneous
Sale
OTC (over the counter)
Earliest approval date in the records

The species, dose forms and routes are the words of the Green Book records for all the applications together. One product can have fewer. The label of a product gives its approved use.

Applications in the Green Book of 2 Nov 2026, pioneer applications (NADA) first
Brand nameActive ingredientsSponsorApproved speciesApplication
Revalor-G; Revalor-IS; Revalor-SEstradiol, Trenbolone AcetateIntervet, Inc.CattleNADA 140-897
Revalor-200; Revalor-H; Revalor-IHEstradiol, Trenbolone AcetateIntervet, Inc.CattleNADA 140-992
Revalor-XH; Revalor-XSEstradiol, Trenbolone AcetateIntervet, Inc.CattleNADA 141-269
Revalor-XREstradiol, Trenbolone AcetateIntervet, Inc.CattleNADA 141-445
Synovex T120; Synovex T40; Synovex T80Estradiol, Trenbolone AcetateZoetis Inc.CattleANADA 200-367

Other pages with one of these ingredients

A report names a drug by its set of active ingredients. Each set has its own page. The list is in order of name.

Next in the A to Z list

All drugs by active ingredient. Brand names A to Z

FDA pages for this drug

The site checked these addresses on . The links open in a new tab.

Cite this page

Pet Drug Reports. Estradiol + Trenbolone Acetate: adverse event reports that FDA received. https://petdrugreports.com/drug/estradiol-trenbolone-acetate/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site does not use the application number that a record has.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about these reports

Which brand are these reports about?

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. The Green Book section of this page lists the brand names with these active ingredients.

Do the reports show that the drug caused the signs?

No. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

How many reports did FDA receive in the latest 12 months?

FDA received 16 reports in the 12 months to June 2026. It received 1 report in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

What kinds of report are in the count?

Of the 267 reports received from January 1995 to December 2025, 56.9% are about a safety issue only. 6.4% are about a lack of expected effectiveness, alone or with a safety issue. 36.7% are about a defect of the product or its package.