Pet Drug Reports

Ceftiofur Crystalline Free Acid (Excede)adverse event reports that FDA received

Active ingredient

The name in brackets is a brand name with this active ingredient.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarianHow to report to FDA

From June 2011 to June 2026, FDA received 2,159 adverse event reports that name a drug with ceftiofur crystalline free acid as its active ingredient. Of the 2,159 reports, 978 (45.3%) are about cattle. 890 reports are about horses (41.2%).

In January to March 2026, FDA received 31 reports that name this drug. The signs that appear in the largest number of the 2,159 reports are "Death" and "Injection site swelling". A report is not proof that a drug caused a sign.

Reports that name this drug fell by 4.7% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about cattle are 45.3% of the reports that name this drug, and 2.3% of all reports.

Since the last update of the FDA data

The latest update of the FDA data, recorded on , changed no count of this page.

January to March 2026 is the latest closed quarter in the data. In that quarter FDA received 31 reports that name ceftiofur crystalline free acid: 0 dog, 0 cat, 20 horse, 11 other or not given.

All updatesFeed of updates (RSS)

Signs that the reports list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 2,159 reports that list the sign. One report can list more than one sign.

The sign that is in the largest number of the reports comes first.

  1. Death26.5%573 reports
  2. Injection site swelling[swelling where the injection was given]22%475 reports
  3. Lack of efficacy (bacteria) - NOS[the product did not have the expected effect: target not specified]15.3%330 reports
  4. Lack of efficacy - NOS[the product did not have the expected effect]13.7%295 reports
  5. Injection site pain[pain where the injection was given]10.9%236 reports
  6. Fever7.6%165 reports
  7. Death by euthanasia[the animal was euthanized]5.3%114 reports
  8. Culture/titer data abnormal4.2%90 reports
  9. Colic4.1%89 reports
  10. Injection site inflammation[inflammation where the injection was given]3.9%84 reports
  11. Ineffective, antibiotic[legacy FDA term: the product did not have the expected effect (antibiotic)]3.7%79 reports
  12. Residues in meat/offal3.6%77 reports
  13. Lethargy[unusually tired or inactive]3.4%73 reports
  14. Abnormal test result3.3%71 reports
Show the next 16 signs
  1. Sudden death3.3%71 reports
  2. Other abnormal test result NOS[abnormal laboratory result, type not specified]3.2%69 reports
  3. Injection site abscess[abscess where the injection was given]3.1%68 reports
  4. Necropsy performed2.7%58 reports
  5. Injection site warmth[warmth where the injection was given]2.5%54 reports
  6. Diarrhoea[diarrhea]2.2%48 reports
  7. Injection site oedema[oedema where the injection was given]2.2%48 reports
  8. Muscle stiffness2.2%47 reports
  9. Collapse2.1%46 reports
  10. Intentional misuse[use that was knowingly different from the label]2.1%46 reports
  11. No sign[no clinical sign was reported]2.1%46 reports
  12. Seizure NOS[seizure, type not specified]2.1%46 reports
  13. Accidental exposure[exposure that was not intended]2.1%45 reports
  14. Tachycardia[fast heart rate]2.1%45 reports
  15. Increased mortality rate2%44 reports
  16. Recumbency[lying down and unable or unwilling to rise]2%44 reports

The list shows 30 of 797 coded signs. A report is not proof that a drug caused a sign. Download all signs (CSV)

Reports by species

The share is of all 2,159 reports that name ceftiofur crystalline free acid. The other reports give a different species or no species.

Reports for each month, Jul 2021 to Jun 2026

Dog3 reports

No chart: no month has 5 or more reports.

Cat3 reports

No chart: no month has 5 or more reports.

Horse287 reports. Largest count in one month: 11 (May 2022)
Other or not given338 reports. Largest count in one month: 14 (Dec 2023)

The month is the month in which FDA received the report. Each chart has its own scale. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports by year

  • Dog
  • Cat
  • Horse
  • Other or not given
Reports that name ceftiofur crystalline free acid, by the year in which FDA received them and by species
YearDogCatHorseOther or not givenAll species
202600262854
2025105574130
2024215778138
2023025766125
2022006260122
2021006270132
2020146663134
2019116897167
2018125978140
2017036183147
2016015164116
2015106790158
20140058131189
20131056124181
20120071103174
201100143852

2026 has the reports that FDA received through Jun 2026. Download the years (CSV)

What the reports record

Outcome at the time of the report

  • Recovered/Normal20.1%433
  • Recovered with Sequela[recovered, with a lasting effect]2.5%53
  • Ongoing18%388
  • Died36.7%793
  • Euthanized6.6%143
  • Outcome Unknown35.5%766

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 2,159 reports that name ceftiofur crystalline free acid.

A report about more than one animal can have more than one outcome.

Kind of report

  • Safety issue63.5%1,370
  • Lack of expected effectiveness27.7%598
  • Both safety and lack of expected effectiveness2.9%63
  • Manufacturing or product defect5.9%128
  • Other0%0

2,036 reports say if the event was serious. 71.5% of them have the serious flag. The person who sends the report sets the flag.

Show age, weight, breed and route

Age of the animal

  • Under 1 year11%238
  • 1 to 3 years12.5%270
  • 4 to 7 years8.5%183
  • 8 to 11 years6.5%140
  • 12 years and over20.1%433
  • Age not given41.5%895

Weight of the animal

  • Under 5 kg (11 lb)0.6%14
  • 5 to 9.9 kg (11 to 22 lb)0.4%9
  • 10 to 24.9 kg (22 to 55 lb)0.5%11
  • 25 to 44.9 kg (55 to 99 lb)1.2%25
  • 45 kg and over (99 lb and over)57.1%1,232
  • Weight not given40.2%868

Breed, where the report gives one breed

A breed with many animals has many reports.

Route in the report

  • Intramuscular42.5%918
  • Subcutaneous17.8%385
  • Intravenous0.4%9
  • Oral0.2%5
  • Other0.1%3
  • Topical0.1%3

Each bar is on a scale of 0 to 100%.

Approved animal drugs with this active ingredient (FDA Green Book)

This section is reference data. It has no report count.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Brand names

  • Excede

What the Green Book records give

Applications with an approval in force
2
Approved species
Cattle, Horses, Swine
Dose forms
Sterile suspension
Routes
Intramuscular, Subcutaneous
Sale
RX (prescription)
Earliest approval date in the records

The species, dose forms and routes are the words of the Green Book records for all the applications together. One product can have fewer. The label of a product gives its approved use.

Applications in the Green Book of 2 Nov 2026, pioneer applications (NADA) first
Brand nameActive ingredientsSponsorApproved speciesApplication
ExcedeCeftiofur Crystalline Free AcidZoetis Inc.Horses, CattleNADA 141-209
Excede FOR SwineCeftiofur Crystalline Free AcidZoetis Inc.SwineNADA 141-235

Next in the A to Z list

All drugs by active ingredient. Brand names A to Z

FDA pages for this drug

The site checked these addresses on . The links open in a new tab.

Cite this page

Pet Drug Reports. Ceftiofur Crystalline Free Acid: adverse event reports that FDA received. https://petdrugreports.com/drug/ceftiofur-crystalline-free-acid/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .

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Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site does not use the application number that a record has.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about these reports

Which brand are these reports about?

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. The Green Book section of this page lists the brand names with this active ingredient.

Do the reports show that the drug caused the signs?

No. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

How many reports did FDA receive in the latest 12 months?

FDA received 123 reports in the 12 months to June 2026. It received 129 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

What kinds of report are in the count?

Of the 2,159 reports received from June 2011 to June 2026, 63.5% are about a safety issue only. 30.6% are about a lack of expected effectiveness, alone or with a safety issue. 5.9% are about a defect of the product or its package.