Active ingredient · pooled across combinations
Chlortetracycline: adverse event reports, pooled
6 ingredient sets in reports · 51 FDA-approved applications in the Green Book
146 adverse event reports received by FDA list a drug containing chlortetracycline, alone or in combination, from June 1990 to December 2025. This page pools every ingredient set that includes it; 6 such sets appear in reports.
The Green Book lists 51 FDA-approved applications containing it. openFDA masks brand and manufacturer names in adverse event records, so the reports counted here cannot be attributed to a particular brand.
7 reports arrived in the 12 months to March 2026, up 40% from 5 in the 12 months before. FDA posts reports quarterly with a delay of three to six months, so the newest months are incomplete and usually grow in later releases. That is about 4 reports a year over its reporting history and 0% of all reports.
Pooled across every set, the terms listed most often are death (33.6%), lack of efficacy (bacteria) - NOS (13%) and lack of efficacy - NOS (7.5%). Many drugs combine several ingredients, and many reports list several drugs, so a term on this page may relate to any of them or to none.
Of reports that state seriousness, 70.5% were classed as serious (38.6% across the whole database); 44.5% record a death or euthanasia (6.4% overall). Ingredients used in older or sicker animals, or in anaesthesia and cancer care, carry higher shares for that reason alone.
Ingredient sets that include chlortetracycline
| Active ingredients recorded for the drug | Reports | Share of this page's reports | Latest 12 months |
|---|---|---|---|
| Chlortetracycline | 125 | 85.6% | 7 |
| Chlortetracycline + Sulfamethazine | 16 | 11% | 0 |
| Chlortetracycline + Lasalocid | 2 | 1.4% | 0 |
| Chlortetracycline + Roxarsone | 1 | 0.7% | 0 |
| Chlortetracycline + Chlortetracycline Hydrochloride | 1 | 0.7% | 0 |
| Chlortetracycline + Sulfamerazine | 1 | 0.7% | 0 |
Ordered by report count. FDA states that these data "cannot be used to estimate the risk associated with the product or compare one drug or device product with another"; counts follow sales volume and years on the market. A report can list more than one set, so shares can add to more than 100%.
Signs listed in reports, pooled
share of chlortetracycline reports listing the termall reports in the database
- Death33.6%49
- Lack of efficacy (bacteria) - NOS[the product did not have the expected effect: target not specified]13%19
- Lack of efficacy - NOS[the product did not have the expected effect]7.5%11
- NT - Abnormal necropsy finding NOS[NOS: not otherwise specified]6.8%10
- Lameness6.2%9
- No sign[no clinical sign was reported]6.2%9
- Color, Abnormal[a product quality report, not a sign in an animal]4.8%7
- Accidental exposure[exposure that was not intended]4.1%6
- Anorexia[not eating]4.1%6
- Lack of efficacy (protozoa) - Coccidia[the product did not have the expected effect: coccidia]4.1%6
- Necropsy performed4.1%6
- Pneumonia[lung infection or inflammation]4.1%6
- Potency, Low4.1%6
- Vocalisation[crying out or unusual noise]4.1%6
- Weight loss4.1%6
- Cough3.4%5
- Lethargy[unusually tired or inactive]3.4%5
- Other abnormal test result NOS[abnormal laboratory result, type not specified]3.4%5
- Abnormal test result2.7%4
- Cardiac disorder NOS[heart problem, type not specified]2.7%4
- Death by euthanasia[the animal was euthanized]2.7%4
- Lateral recumbency[lying on the side, unable to rise]2.7%4
- Residues in milk2.7%4
- Ruminal bloat2.7%4
- Bronchopneumonia2.1%3
- Contamination, Mold2.1%3
- Diarrhoea[diarrhea]2.1%3
- Found dead2.1%3
Pooled across every ingredient set and every report that names the ingredient. One report can list several terms and several drugs; a term here may relate to any of them or to none.
Monthly reports by species, five years
By month of receipt; each panel has its own scale. The newest months are incomplete because FDA posts reports with a delay of three to six months.
Outcomes, report types and ages
Outcome recorded in the report
What kind of report it was
Age of the animal
Coloured bar: reports naming chlortetracycline. Grey bar: all 1,357,245 reports. Outcomes are as stated by the reporter; FDA has not necessarily determined whether any product played a part.
In context
| Measure | Chlortetracycline | All reports |
|---|---|---|
| Reports | 146 | 1,357,245 |
| Latest 12 months against the 12 before | +40% | -5% |
| Classed serious, of reports stating it | 70.5% | 38.6% |
| Death or euthanasia recorded, per 1,000 reports | 445.2 | 63.8 |
| Filed as lack of expected effectiveness (wholly or partly) | 24% | 23% |
Shares of reports, not of animals treated: how many animals receive the ingredient is not public. Ingredients used in anaesthesia, cancer care or in old animals carry more serious outcomes in their reports for that reason alone.
FDA-approved products containing chlortetracycline (Green Book)
Reference information, not report statistics. openFDA masks brand and manufacturer names in adverse event records, so the reports counted here cannot be attributed to a particular brand. The list below is the FDA Green Book as of 1 Oct 2026; nothing on this page says which of these products, if any, a report concerned.
| Trade name | Active ingredients | Sponsor | Approved for | Application |
|---|---|---|---|---|
| Aureomix S 40/40 Granular | Chlortetracycline, Sulfamethazine | Phibro Animal Health Corp. | Swine | NADA 035-688 |
| Aureo S 700 Granular; Aureo S 700 | Chlortetracycline, Sulfamethazine | Phibro Animal Health Corp. | Cattle | NADA 035-805 |
| Amprol Plus and Aureomycin | Amprolium, Chlortetracycline, Ethopabate | Phibro Animal Health Corp. | Chickens | NADA 036-361 |
| Aureomix S 700-A | Chlortetracycline, Sulfamethazine | Phibro Animal Health Corp. | Cattle | NADA 041-647 |
| Aureomix S 700-D | Chlortetracycline, Sulfamethazine | Phibro Animal Health Corp. | Cattle | NADA 041-648 |
| Aureomix S 700-G | Chlortetracycline, Sulfamethazine | Phibro Animal Health Corp. | Cattle | NADA 041-649 |
| Aureomix S 700-E | Chlortetracycline, Sulfamethazine | Phibro Animal Health Corp. | Cattle | NADA 041-650 |
| Aureomix 700-F | Chlortetracycline, Sulfamethazine | Phibro Animal Health Corp. | Cattle | NADA 041-651 |
| Aureomix S 700-C | Chlortetracycline, Sulfamethazine | Phibro Animal Health Corp. | Cattle | NADA 041-652 |
| Aureomix S 700-B | Chlortetracycline, Sulfamethazine | Phibro Animal Health Corp. | Cattle | NADA 041-653 |
| Aureomix S 700-H | Chlortetracycline, Sulfamethazine | Phibro Animal Health Corp. | Cattle | NADA 041-654 |
| Deccox and Aureomycin | Chlortetracycline, Decoquinate | Phibro Animal Health Corp. | Chickens | NADA 045-444 |
| Coyden plus CTC | Chlortetracycline, Clopidol | Huvepharma EOOD | Chickens | NADA 046-209 |
| Chloratet 100; Chloratet 50; Chloratet 90 | Chlortetracycline | Pharmgate Inc. | Cattle, Swine, Chickens, Turkeys | NADA 048-480 |
| Aureomycin 50 Granular; Aureomycin 50 Granular A; Aureomycin 70 Granular; Aureomycin 80 Granular; Aureomycin 90 Granular; Aureomycin 90 Meal; Aureomycin 100 Granular | Chlortetracycline | Phibro Animal Health Corp. | Cattle, Swine, Chickens, Turkeys, Sheep | NADA 048-761 |
| Robenz and Aureomycin | Chlortetracycline, Robenidine Hydrochloride | Phibro Animal Health Corp. | Chickens | NADA 092-507 |
| PfiChlor 100S | Chlortetracycline | Zoetis Inc. | Cattle | NADA 100-901 |
| Aureomycin and Coban | Chlortetracycline, Monensin | Phibro Animal Health Corp. | Chickens | NADA 121-553 |
| Pennchlor S 40/40 | Chlortetracycline, Sulfamethazine | Pharmgate Inc. | Swine | NADA 138-934 |
| Pennchlor 50; Pennchlor 50 G; Pennchlor 90 G; Pennchlor 100 G; Pennchlor 100 Hi-Flo | Chlortetracycline | Pharmgate Inc. | Cattle, Swine, Chickens, Turkeys, Sheep | NADA 138-935 |
| Bio-Cox and Aureomycin | Chlortetracycline, Salinomycin Sodium | Phibro Animal Health Corp. | Chickens | NADA 140-859 |
| Denagard plus CTC | Chlortetracycline, Tiamulin Hydrogen Fumarate | Elanco US Inc. | Swine | NADA 141-011 |
| BMD and ChlorMax | Bacitracin methylenedisalicylate, Chlortetracycline | Phibro Animal Health Corp. | Swine | NADA 141-059 |
| Deccox and ChlorMax | Chlortetracycline, Decoquinate | Phibro Animal Health Corp. | Cattle | NADA 141-147 |
| Aureomycin and Deccox | Chlortetracycline, Decoquinate | Phibro Animal Health Corp. | Cattle | NADA 141-185 |
| Aureomycin and Cattlyst | Chlortetracycline, Laidlomycin Propionate Potassium | Phibro Animal Health Corp. | Cattle | NADA 141-201 |
| Aureomycin and Bovatec | Chlortetracycline, Lasalocid sodium | Phibro Animal Health Corp. | Cattle | NADA 141-250 |
| MGA and Aureomycin | Chlortetracycline, Melengestrol Acetate | Phibro Animal Health Corp. | Cattle | NADA 141-530 |
| MGA and Bovatec and Aureomycin | Chlortetracycline, Lasalocid, Melengestrol Acetate | Phibro Animal Health Corp. | Cattle | NADA 141-531 |
| Aureo S 700 and Bovatec | Chlortetracycline, Lasalocid, Sulfamethazine | Phibro Animal Health Corp. | Cattle | NADA 141-535 |
| Pennchlor and Rumensin | Chlortetracycline, Monensin | Pharmgate Inc. | Cattle | NADA 141-564 |
| BMD and Aureomycin | Bacitracin methylenedisalicylate, Chlortetracycline | Phibro Animal Health Corp. | Swine | ANADA 200-242 |
| Bio-Cox and ChlorMax | Chlortetracycline, Salinomycin Sodium | Phibro Animal Health Corp. | Chickens | ANADA 200-261 |
| Sacox and ChlorMax | Chlortetracycline, Salinomycin Sodium | Phibro Animal Health Corp. | Chickens | ANADA 200-262 |
| ChlorMax and Coban | Chlortetracycline, Monensin | Phibro Animal Health Corp. | Chickens | ANADA 200-263 |
| Pennchlor S | Chlortetracycline, Sulfamethazine | Pharmgate Inc. | Cattle | ANADA 200-314 |
| Pennchlor and Coban | Chlortetracycline, Monensin | Pharmgate Inc. | Chickens | ANADA 200-354 |
| Bio-Cox and Pennchlor | Chlortetracycline, Salinomycin Sodium | Pharmgate Inc. | Chickens | ANADA 200-357 |
| BMD and Pennchlor | Bacitracin methylenedisalicylate, Chlortetracycline | Pharmgate Inc. | Swine | ANADA 200-358 |
| Pennchlor and Deccox | Chlortetracycline, Decoquinate | Pharmgate Inc. | Cattle | ANADA 200-359 |
| Deracin 50 Meal; Deracin 90 Meal; Deracin 100 Meal | Chlortetracycline | Pharmgate Inc. | Cattle, Swine, Chickens, Turkeys, Sheep | ANADA 200-510 |
| Deracin plus Bovatec | Chlortetracycline, Lasalocid | Pharmgate Inc. | Cattle | ANADA 200-617 |
| Deccox and Deracin | Chlortetracycline, Decoquinate | Pharmgate Inc. | Cattle | ANADA 200-622 |
| Denagard and Deracin | Chlortetracycline, Tiamulin | Pharmgate Inc. | Swine | ANADA 200-633 |
| Pennchlor and Monovet | Chlortetracycline, Monensin | Huvepharma EOOD | Cattle | ANADA 200-748 |
| MGA and Deracin | Chlortetracycline, Melengestrol Acetate | Pharmgate Inc. | Cattle | ANADA 200-770 |
| MGA and Bovatec and Deracin | Chlortetracycline, Lasalocid, Melengestrol Acetate | Pharmgate Inc. | Cattle | ANADA 200-776 |
| Rainbow Broiler Base Concentrateapproval voluntarily withdrawn | Amprolium, Chlortetracycline, Ethopabate | Stockton Hay & Grain Co. | Chickens | NADA 091-647 |
| 3-Nitro / ChlorMax / Sacoxapproval voluntarily withdrawn | Chlortetracycline, Roxarsone, Salinomycin Sodium | Zoetis Inc. | Chickens | ANADA 200-259 |
| 3-Nitro / Bio-Cox / ChlorMaxapproval voluntarily withdrawn | Chlortetracycline, Roxarsone, Salinomycin Sodium | Zoetis Inc. | Chickens | ANADA 200-260 |
| Pennchlor / Bio-Cox / 3-Nitroapproval voluntarily withdrawn | Chlortetracycline, Roxarsone, Salinomycin Sodium | Pennfield Oil Co. | Chickens | ANADA 200-355 |
Species are the major species the Green Book search lists for the application ("—" where it lists another species or none). Approval dates are not part of the Green Book listing files and are not shown. Pioneer applications (NADA) come first, then generics (ANADA).
Questions about chlortetracycline reports
How many FDA adverse event reports mention chlortetracycline?
146 reports through March 2026, 7 of them in the latest 12 months, counting chlortetracycline alone and in combinations.
Which brands do these reports concern?
That cannot be known from the public data. openFDA masks brand and manufacturer names in adverse event records, so the reports counted here cannot be attributed to a particular brand. The Green Book reference list on this page names approved products containing chlortetracycline without any counts.
In which combinations is chlortetracycline reported?
Chlortetracycline (85.6% of these reports), Chlortetracycline + Sulfamethazine (11% of these reports), Chlortetracycline + Lasalocid (1.4% of these reports), Chlortetracycline + Roxarsone (0.7% of these reports) and Chlortetracycline + Chlortetracycline Hydrochloride (0.7% of these reports).
What reactions are reported for chlortetracycline?
death (33.6%), lack of efficacy (bacteria) - NOS (13%), lack of efficacy - NOS (7.5%), nT - Abnormal necropsy finding NOS (6.8%) and lameness (6.2%). Shares are of reports naming the ingredient; one report can list several terms.
Which animals are these reports about?
cattle (43.8%), pig (21.9%) and horse (2.7%).
Does a high count mean chlortetracycline is a problem ingredient?
A count cannot show that. FDA states that "there is no certainty that the reported drug or device caused the adverse event" and that the event "may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources." Widely used ingredients collect more reports because more animals receive them.
How do I report a problem?
Call the drug company using the number on the label, or send Form FDA 1932a to FDA. See the guide on how to report.
Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 1 Oct 2026. Ingredient names follow the Green Book; salts and forms are kept as FDA lists them. Drug entries are matched by the active ingredients their unmasked ingredient field discloses. No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.