Pet Drug Reports

Ingredients

Active ingredient · pooled across combinations

Chlortetracycline: adverse event reports, pooled

6 ingredient sets in reports · 51 FDA-approved applications in the Green Book

146reports naming the ingredient, 1990–20250% of all reports · about 4 a year
7reports, 12 months to March 20265 in the 12 months before
70.5%classed serious, as reportedall reports: 38.6%
43.8%of reports concern cattlepig 21.9%

146 adverse event reports received by FDA list a drug containing chlortetracycline, alone or in combination, from June 1990 to December 2025. This page pools every ingredient set that includes it; 6 such sets appear in reports.

The Green Book lists 51 FDA-approved applications containing it. openFDA masks brand and manufacturer names in adverse event records, so the reports counted here cannot be attributed to a particular brand.

7 reports arrived in the 12 months to March 2026, up 40% from 5 in the 12 months before. FDA posts reports quarterly with a delay of three to six months, so the newest months are incomplete and usually grow in later releases. That is about 4 reports a year over its reporting history and 0% of all reports.

Pooled across every set, the terms listed most often are death (33.6%), lack of efficacy (bacteria) - NOS (13%) and lack of efficacy - NOS (7.5%). Many drugs combine several ingredients, and many reports list several drugs, so a term on this page may relate to any of them or to none.

Of reports that state seriousness, 70.5% were classed as serious (38.6% across the whole database); 44.5% record a death or euthanasia (6.4% overall). Ingredients used in older or sicker animals, or in anaesthesia and cancer care, carry higher shares for that reason alone.

Ingredient sets that include chlortetracycline

Active ingredients recorded for the drugReportsShare of this page's reportsLatest 12 months
Chlortetracycline12585.6%7
Chlortetracycline + Sulfamethazine1611%0
Chlortetracycline + Lasalocid21.4%0
Chlortetracycline + Roxarsone10.7%0
Chlortetracycline + Chlortetracycline Hydrochloride10.7%0
Chlortetracycline + Sulfamerazine10.7%0

Ordered by report count. FDA states that these data "cannot be used to estimate the risk associated with the product or compare one drug or device product with another"; counts follow sales volume and years on the market. A report can list more than one set, so shares can add to more than 100%.

Signs listed in reports, pooled

share of chlortetracycline reports listing the termall reports in the database

  1. Death33.6%49
  2. Lack of efficacy (bacteria) - NOS[the product did not have the expected effect: target not specified]13%19
  3. Lack of efficacy - NOS[the product did not have the expected effect]7.5%11
  4. NT - Abnormal necropsy finding NOS[NOS: not otherwise specified]6.8%10
  5. No sign[no clinical sign was reported]6.2%9
  6. Color, Abnormal[a product quality report, not a sign in an animal]4.8%7
  7. Accidental exposure[exposure that was not intended]4.1%6
  8. Anorexia[not eating]4.1%6
  9. Lack of efficacy (protozoa) - Coccidia[the product did not have the expected effect: coccidia]4.1%6
  10. Pneumonia[lung infection or inflammation]4.1%6
  11. Vocalisation[crying out or unusual noise]4.1%6
  12. Cough3.4%5
  13. Lethargy[unusually tired or inactive]3.4%5
  14. Other abnormal test result NOS[abnormal laboratory result, type not specified]3.4%5
  15. Cardiac disorder NOS[heart problem, type not specified]2.7%4
  16. Death by euthanasia[the animal was euthanized]2.7%4
  17. Lateral recumbency[lying on the side, unable to rise]2.7%4
  18. Bronchopneumonia2.1%3
  19. Diarrhoea[diarrhea]2.1%3

Pooled across every ingredient set and every report that names the ingredient. One report can list several terms and several drugs; a term here may relate to any of them or to none.

Monthly reports by species, five years

Dog0 · peak 1
2022202320242025
Cat0 · peak 1
2022202320242025
Horse0 · peak 1
2022202320242025
Other28 · peak 3
Oct 2021: 2Nov 2021: 1Dec 2021: 1Mar 2022: 1Aug 2022: 1Oct 2022: 1Dec 2022: 1Mar 2023: 1Jul 2023: 1Sep 2023: 2Nov 2023: 1Jan 2024: 3Aug 2024: 2Oct 2024: 1Nov 2024: 1Dec 2024: 1Apr 2025: 1Jul 2025: 1Aug 2025: 1Sep 2025: 2Dec 2025: 22022202320242025

By month of receipt; each panel has its own scale. The newest months are incomplete because FDA posts reports with a delay of three to six months.

09181990: 119902002: 12005: 220052007: 22008: 120082009: 32010: 120102011: 132012: 420122013: 152014: 1620142015: 182016: 1520162017: 62018: 1420182019: 22020: 320202021: 52022: 420222023: 52024: 820242025: 7

Outcomes, report types and ages

Outcome recorded in the report

Recovered/Normal8.9%13
Recovered with Sequela1.4%2
Ongoing8.2%12
Died42.5%62
Euthanized5.5%8
Outcome Unknown33.6%49

What kind of report it was

Safety issue50%73
Lack of expected effectiveness19.9%29
Both safety and lack of expected effectiveness4.1%6
Manufacturing or product defect26%38
Other0%0

Species

Cattle43.8%64
Pig21.9%32
Horse2.7%4
Sheep2.7%4
Dog0.7%1
Human exposure0.7%1

Age of the animal

Under 1 year24%35
1 to 3 years4.1%6
4 to 7 years0.7%1
8 to 11 years0%0
12 years and over0%0
Age not given71.2%104

Coloured bar: reports naming chlortetracycline. Grey bar: all 1,357,245 reports. Outcomes are as stated by the reporter; FDA has not necessarily determined whether any product played a part.

In context

MeasureChlortetracyclineAll reports
Reports1461,357,245
Latest 12 months against the 12 before+40%-5%
Classed serious, of reports stating it70.5%38.6%
Death or euthanasia recorded, per 1,000 reports445.263.8
Filed as lack of expected effectiveness (wholly or partly)24%23%

Shares of reports, not of animals treated: how many animals receive the ingredient is not public. Ingredients used in anaesthesia, cancer care or in old animals carry more serious outcomes in their reports for that reason alone.

FDA-approved products containing chlortetracycline (Green Book)

Reference information, not report statistics. openFDA masks brand and manufacturer names in adverse event records, so the reports counted here cannot be attributed to a particular brand. The list below is the FDA Green Book as of 1 Oct 2026; nothing on this page says which of these products, if any, a report concerned.

Trade nameActive ingredientsSponsorApproved forApplication
Aureomix S 40/40 GranularChlortetracycline, SulfamethazinePhibro Animal Health Corp.SwineNADA 035-688
Aureo S 700 Granular; Aureo S 700Chlortetracycline, SulfamethazinePhibro Animal Health Corp.CattleNADA 035-805
Amprol Plus and AureomycinAmprolium, Chlortetracycline, EthopabatePhibro Animal Health Corp.ChickensNADA 036-361
Aureomix S 700-AChlortetracycline, SulfamethazinePhibro Animal Health Corp.CattleNADA 041-647
Aureomix S 700-DChlortetracycline, SulfamethazinePhibro Animal Health Corp.CattleNADA 041-648
Aureomix S 700-GChlortetracycline, SulfamethazinePhibro Animal Health Corp.CattleNADA 041-649
Aureomix S 700-EChlortetracycline, SulfamethazinePhibro Animal Health Corp.CattleNADA 041-650
Aureomix 700-FChlortetracycline, SulfamethazinePhibro Animal Health Corp.CattleNADA 041-651
Aureomix S 700-CChlortetracycline, SulfamethazinePhibro Animal Health Corp.CattleNADA 041-652
Aureomix S 700-BChlortetracycline, SulfamethazinePhibro Animal Health Corp.CattleNADA 041-653
Aureomix S 700-HChlortetracycline, SulfamethazinePhibro Animal Health Corp.CattleNADA 041-654
Deccox and AureomycinChlortetracycline, DecoquinatePhibro Animal Health Corp.ChickensNADA 045-444
Coyden plus CTCChlortetracycline, ClopidolHuvepharma EOODChickensNADA 046-209
Chloratet 100; Chloratet 50; Chloratet 90ChlortetracyclinePharmgate Inc.Cattle, Swine, Chickens, TurkeysNADA 048-480
Aureomycin 50 Granular; Aureomycin 50 Granular A; Aureomycin 70 Granular; Aureomycin 80 Granular; Aureomycin 90 Granular; Aureomycin 90 Meal; Aureomycin 100 GranularChlortetracyclinePhibro Animal Health Corp.Cattle, Swine, Chickens, Turkeys, SheepNADA 048-761
Robenz and AureomycinChlortetracycline, Robenidine HydrochloridePhibro Animal Health Corp.ChickensNADA 092-507
PfiChlor 100SChlortetracyclineZoetis Inc.CattleNADA 100-901
Aureomycin and CobanChlortetracycline, MonensinPhibro Animal Health Corp.ChickensNADA 121-553
Pennchlor S 40/40Chlortetracycline, SulfamethazinePharmgate Inc.SwineNADA 138-934
Pennchlor 50; Pennchlor 50 G; Pennchlor 90 G; Pennchlor 100 G; Pennchlor 100 Hi-FloChlortetracyclinePharmgate Inc.Cattle, Swine, Chickens, Turkeys, SheepNADA 138-935
Bio-Cox and AureomycinChlortetracycline, Salinomycin SodiumPhibro Animal Health Corp.ChickensNADA 140-859
Denagard plus CTCChlortetracycline, Tiamulin Hydrogen FumarateElanco US Inc.SwineNADA 141-011
BMD and ChlorMaxBacitracin methylenedisalicylate, ChlortetracyclinePhibro Animal Health Corp.SwineNADA 141-059
Deccox and ChlorMaxChlortetracycline, DecoquinatePhibro Animal Health Corp.CattleNADA 141-147
Aureomycin and DeccoxChlortetracycline, DecoquinatePhibro Animal Health Corp.CattleNADA 141-185
Aureomycin and CattlystChlortetracycline, Laidlomycin Propionate PotassiumPhibro Animal Health Corp.CattleNADA 141-201
Aureomycin and BovatecChlortetracycline, Lasalocid sodiumPhibro Animal Health Corp.CattleNADA 141-250
MGA and AureomycinChlortetracycline, Melengestrol AcetatePhibro Animal Health Corp.CattleNADA 141-530
MGA and Bovatec and AureomycinChlortetracycline, Lasalocid, Melengestrol AcetatePhibro Animal Health Corp.CattleNADA 141-531
Aureo S 700 and BovatecChlortetracycline, Lasalocid, SulfamethazinePhibro Animal Health Corp.CattleNADA 141-535
Pennchlor and RumensinChlortetracycline, MonensinPharmgate Inc.CattleNADA 141-564
BMD and AureomycinBacitracin methylenedisalicylate, ChlortetracyclinePhibro Animal Health Corp.SwineANADA 200-242
Bio-Cox and ChlorMaxChlortetracycline, Salinomycin SodiumPhibro Animal Health Corp.ChickensANADA 200-261
Sacox and ChlorMaxChlortetracycline, Salinomycin SodiumPhibro Animal Health Corp.ChickensANADA 200-262
ChlorMax and CobanChlortetracycline, MonensinPhibro Animal Health Corp.ChickensANADA 200-263
Pennchlor SChlortetracycline, SulfamethazinePharmgate Inc.CattleANADA 200-314
Pennchlor and CobanChlortetracycline, MonensinPharmgate Inc.ChickensANADA 200-354
Bio-Cox and PennchlorChlortetracycline, Salinomycin SodiumPharmgate Inc.ChickensANADA 200-357
BMD and PennchlorBacitracin methylenedisalicylate, ChlortetracyclinePharmgate Inc.SwineANADA 200-358
Pennchlor and DeccoxChlortetracycline, DecoquinatePharmgate Inc.CattleANADA 200-359
Deracin 50 Meal; Deracin 90 Meal; Deracin 100 MealChlortetracyclinePharmgate Inc.Cattle, Swine, Chickens, Turkeys, SheepANADA 200-510
Deracin plus BovatecChlortetracycline, LasalocidPharmgate Inc.CattleANADA 200-617
Deccox and DeracinChlortetracycline, DecoquinatePharmgate Inc.CattleANADA 200-622
Denagard and DeracinChlortetracycline, TiamulinPharmgate Inc.SwineANADA 200-633
Pennchlor and MonovetChlortetracycline, MonensinHuvepharma EOODCattleANADA 200-748
MGA and DeracinChlortetracycline, Melengestrol AcetatePharmgate Inc.CattleANADA 200-770
MGA and Bovatec and DeracinChlortetracycline, Lasalocid, Melengestrol AcetatePharmgate Inc.CattleANADA 200-776
Rainbow Broiler Base Concentrateapproval voluntarily withdrawnAmprolium, Chlortetracycline, EthopabateStockton Hay & Grain Co.ChickensNADA 091-647
3-Nitro / ChlorMax / Sacoxapproval voluntarily withdrawnChlortetracycline, Roxarsone, Salinomycin SodiumZoetis Inc.ChickensANADA 200-259
3-Nitro / Bio-Cox / ChlorMaxapproval voluntarily withdrawnChlortetracycline, Roxarsone, Salinomycin SodiumZoetis Inc.ChickensANADA 200-260
Pennchlor / Bio-Cox / 3-Nitroapproval voluntarily withdrawnChlortetracycline, Roxarsone, Salinomycin SodiumPennfield Oil Co.ChickensANADA 200-355

Species are the major species the Green Book search lists for the application ("—" where it lists another species or none). Approval dates are not part of the Green Book listing files and are not shown. Pioneer applications (NADA) come first, then generics (ANADA).

Questions about chlortetracycline reports

How many FDA adverse event reports mention chlortetracycline?

146 reports through March 2026, 7 of them in the latest 12 months, counting chlortetracycline alone and in combinations.

Which brands do these reports concern?

That cannot be known from the public data. openFDA masks brand and manufacturer names in adverse event records, so the reports counted here cannot be attributed to a particular brand. The Green Book reference list on this page names approved products containing chlortetracycline without any counts.

In which combinations is chlortetracycline reported?

Chlortetracycline (85.6% of these reports), Chlortetracycline + Sulfamethazine (11% of these reports), Chlortetracycline + Lasalocid (1.4% of these reports), Chlortetracycline + Roxarsone (0.7% of these reports) and Chlortetracycline + Chlortetracycline Hydrochloride (0.7% of these reports).

What reactions are reported for chlortetracycline?

death (33.6%), lack of efficacy (bacteria) - NOS (13%), lack of efficacy - NOS (7.5%), nT - Abnormal necropsy finding NOS (6.8%) and lameness (6.2%). Shares are of reports naming the ingredient; one report can list several terms.

Which animals are these reports about?

cattle (43.8%), pig (21.9%) and horse (2.7%).

Does a high count mean chlortetracycline is a problem ingredient?

A count cannot show that. FDA states that "there is no certainty that the reported drug or device caused the adverse event" and that the event "may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources." Widely used ingredients collect more reports because more animals receive them.

How do I report a problem?

Call the drug company using the number on the label, or send Form FDA 1932a to FDA. See the guide on how to report.

Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 1 Oct 2026. Ingredient names follow the Green Book; salts and forms are kept as FDA lists them. Drug entries are matched by the active ingredients their unmasked ingredient field discloses. No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.