Breed · Cat
Domestic Shorthair: adverse event reports
FDA breed label "Domestic Shorthair" · single-breed animals only
FDA's database holds 64,581 reports where the animal's breed is given as "Domestic Shorthair", shown here as Domestic Shorthair: 43.6% of reports about cats. Reports on crossbred animals are left out of breed pages.
7,401 reports arrived in the 12 months to March 2026, down 10% from 8,267 in the 12 months before. A breed's count mostly mirrors how common the breed is; registration and ownership figures by breed are not public data, so no per-animal rate can be given.
By active ingredient, the drugs named most often are selamectin, spinosad and fluralaner. Selamectin is named in 9.9% of this breed's reports, a smaller share than in reports about all cats (14.8%).
The terms listed most often are lethargy (13.4%), vomiting (12.3%) and application site hair loss (8.1%). Lethargy appears in 13.4% of reports, a larger share than in all cat reports (9.7%). 38.1% of reports stating seriousness were classed as serious, against 35.6% for cats overall.
Drugs named most often, by active ingredient
| Active ingredients recorded for the drug | Reports | Share of Domestic Shorthair reports | Share of all cat reports |
|---|---|---|---|
| Selamectin | 6,395 | 9.9% | 14.8% |
| Spinosad | 6,359 | 9.8% | 7.8% |
| Fluralaner | 6,322 | 9.8% | 7% |
| Frunevetmab | 4,657 | 7.2% | 5.1% |
| Sarolaner + Selamectin | 4,524 | 7% | 5.3% |
| Cefovecin sodium | 4,294 | 6.6% | 5.8% |
| Imidacloprid + Moxidectin | 3,942 | 6.1% | 5.5% |
| Nitenpyram | 3,412 | 5.3% | 5.8% |
| Emodepside + Praziquantel | 3,323 | 5.1% | 3.8% |
| Velagliflozin | 2,928 | 4.5% | 2.9% |
| Buprenorphine | 2,805 | 4.3% | 3.7% |
| Bexagliflozin | 2,379 | 3.7% | 2.5% |
| Maropitant | 2,062 | 3.2% | 2.5% |
| Fluralaner + Moxidectin | 1,975 | 3.1% | 2.1% |
| Robenacoxib | 1,835 | 2.8% | 2.2% |
| Eprinomectin + Esafoxolaner + Praziquantel | 1,833 | 2.8% | 2% |
| Insulin | 1,636 | 2.5% | 2.4% |
| Cyclosporine | 1,551 | 2.4% | 2% |
| Gabapentin | 1,171 | 1.8% | 1.2% |
| Ketamine Hydrochloride | 1,070 | 1.7% | 2.5% |
Ordered by report count. Differences from the species column often come from body size (which drugs a breed is prescribed) and from how common the breed was in the years a drug sold most. FDA states that these data cannot be used to estimate risk or to compare one product with another. Brand and manufacturer names are masked by FDA in these records.
Signs listed in reports
share of Domestic Shorthair reports listing the termall cat reports
- Lethargy[unusually tired or inactive]13.4%8,633
- Vomiting12.3%7,954
- Application site hair loss[hair loss where the product was applied]8.1%5,243
- Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]7.1%4,563
- Lack of efficacy - NOS[the product did not have the expected effect]5.8%3,724
- Application site alopecia[hair loss where the product was applied]5.6%3,605
- Weight loss5.4%3,473
- Anorexia[not eating]5.4%3,472
- Emesis[vomiting]5.3%3,443
- Behavioural disorder NOS[behaviour change, type not specified]5.2%3,371
- Diarrhoea[diarrhea]4.8%3,107
- Hypersalivation[drooling]4.1%2,669
- Not eating4.1%2,645
- Ataxia[unsteady, uncoordinated movement]3.9%2,545
- Death by euthanasia[the animal was euthanized]3.4%2,204
- Death3.2%2,098
- Ketosis[ketones building up in the body]3.2%2,053
- Decreased appetite3.2%2,047
- Vocalisation[crying out or unusual noise]3%1,913
- Hyperactivity2.8%1,825
- Hiding2.7%1,758
- Other abnormal test result NOS[abnormal laboratory result, type not specified]2.6%1,674
- Application site scab[scab where the product was applied]2.6%1,648
- Pruritus[itching]2.4%1,582
- Emesis (multiple)[vomiting more than once]2.2%1,434
Age and weight
Age of the animal
Weight of the animal
Coloured bar: Domestic Shorthair reports. Grey bar: all cat reports.
Trend and outcomes
Reports by month FDA received them. The newest months are incomplete because FDA posts reports with a delay of three to six months.
Outcome recorded in the report
Beside all cats
| Measure | Domestic Shorthair | All cats |
|---|---|---|
| Reports | 64,581 | 148,080 |
| Latest 12 months | 7,401 | 12,477 |
| Classed serious, of reports stating it | 38.1% | 35.6% |
| Death or euthanasia recorded, per 1,000 reports | 71.9 | 95 |
Questions about Domestic Shorthair reports
How many FDA adverse event reports involve Domestic Shorthairs?
64,581 reports through March 2026, 43.6% of reports about cats; 7,401 in the latest 12 months.
Which drugs are named most often in Domestic Shorthair reports?
By active ingredient: selamectin (6,395), spinosad (6,359), fluralaner (6,322), frunevetmab (4,657) and sarolaner + selamectin (4,524). Brands are masked in the public data.
What signs are reported most for this breed?
lethargy (13.4%), vomiting (12.3%), application site hair loss (8.1%), lack of efficacy (ectoparasite) - flea (7.1%) and lack of efficacy - NOS (5.8%).
Is the Domestic Shorthair more sensitive to certain drugs?
Report counts cannot answer that. They show what was reported, not what a drug did, and they are not adjusted for how many Domestic Shorthair animals exist or were treated. Breed-related drug sensitivities that are established are described on FDA-approved labels; a veterinarian is the person to ask about an individual animal.
Why are crossbreds not included?
FDA records crossbred animals with one or more component breeds. Counting them under each component would double count, so breed pages use single-breed reports only. Crossbreds remain in the species totals.
How do I report a problem?
Call the drug company using the number on the label, or send Form FDA 1932a to FDA. See the guide on how to report.
Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 30 Sep 2026. Breed names are FDA's labels rearranged into everyday order ("Domestic Shorthair" becomes "Domestic Shorthair"). No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.