August 2021: adverse event reports that FDA received

Month in which FDA received the reports

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

FDA received 5,817 adverse event reports for animal drugs in August 2021. It received 6,306 reports in August 2020. The average of the 12 months before August 2021 is 5,504 reports for each month.

Of the 5,817 reports, 74.5% are about dogs, 10.3% are about cats and 1.4% are about horses. The other reports are about other species, or give no species. A report is not proof that a drug caused a sign.

Search engines do not list month pages. The site keeps the page, and the list of months links it.

The months before and after

Reports for each month, Feb 2020 to Feb 2022. The column with the outline is August 2021.

Reports by species

Dog74.5%4,334
Cat10.3%600
Horse1.4%81
Other species, or species not given13.8%802

Drug pages with reports received in August 2021

The table has every drug page with 10 or more reports that FDA received in August 2021, in order of name. No count decides which drug is in the table. The table has 81 drug pages.

Show the 81 drug pages

Drug pages with 10 or more reports received in August 2021, in order of name
Active ingredients	Reports received in August 2021
(S) - methoprene	29
Acepromazine Maleate	13
Afoxolaner	435
Amoxicillin Trihydrate + Clavulanate Potassium	16
Atipamezole Hydrochloride	17
Betamethasone Acetate + Florfenicol + Terbinafine	19
Buprenorphine	22
Butorphanol Tartrate	38
Capromorelin	29
Carprofen	75
Cefovecin sodium	47
Cefpodoxime proxetil	15
Cephalexin	10
Ciclesonide	20
Clotrimazole + Gentamicin	17
Cyclosporine	32
Deracoxib	18
Dexamethasone	13
Dexmedetomidine	16
Dexmedetomidine hydrochloride	39
Diphenhydramine	18
Doxycycline	29
Emodepside + Praziquantel	17
Enrofloxacin	24
Febantel + Praziquantel + Pyrantel Pamoate	43
Fenbendazole	13
Firocoxib	14
Florfenicol + Mometasone furoate + Terbinafine	53
Flunixin Meglumine	10
Fluralaner	632
Fluralaner + Moxidectin	47
Furosemide	10
Gabapentin	40
Gentamicin Sulfate + Hydrocortisone aceponate + Miconazole Nitrate	12
Grapiprant	55
Hydromorphone	18
Imidacloprid	113
Imidacloprid + Moxidectin	97
Insulin	62
Isoflurane	38
Ivermectin	63
Ivermectin + Praziquantel + Pyrantel Pamoate	18
Ivermectin + Pyrantel Pamoate	719
Ketamine Hydrochloride	18
Lotilaner	167
Lufenuron + Milbemycin Oxime	75
Lufenuron + Milbemycin Oxime + Praziquantel	64
Maropitant	83
Melarsomine Dihydrochloride	80
Meloxicam	26
Metronidazole	22
Midazolam	10
Milbemycin Oxime	55
Milbemycin Oxime + Praziquantel	335
Milbemycin Oxime + Spinosad	211
Mirtazapine	24
Monensin	16
Moxidectin	424
Moxidectin + Pyrantel Pamoate + Sarolaner	11
Nitenpyram	157
Oclacitinib	143
Omeprazole	30
Phenobarbital	10
Pimobendan	28
Polysulfated Glycosaminoglycan	29
Praziquantel	15
Praziquantel + Pyrantel Pamoate	23
Prednisolone	13
Prednisone	34
Propofol	24
Pyrantel Pamoate	15
Pyrantel Pamoate + Sarolaner	705
Robenacoxib	14
Sarolaner	138
Sarolaner + Selamectin	127
Selamectin	120
Sodium Chloride	46
Spinosad	53
Tigilanol tiglate	43
Trazodone	12
Trilostane	74

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
Commonly used products may have a higher number of reported adverse events due to the higher total number of animals being given the product.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Signs that the reports of the month list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 5,817 reports of the month.

The sign that is in the largest number of the reports comes first.

Vomiting16.1%938 reports
Lack of efficacy (endoparasite) - heartworm[the product did not have the expected effect: heartworm]10.1%585 reports
Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]8.7%507 reports
Lethargy[unusually tired or inactive]7.3%423 reports
Lack of efficacy (endoparasite) - hookworm[the product did not have the expected effect: hookworms]6.8%394 reports
Diarrhoea[diarrhea]5.8%339 reports
Seizure NOS[seizure, type not specified]4%230 reports
Lack of efficacy - NOS[the product did not have the expected effect]2.6%153 reports
Death2.6%152 reports
Lack of efficacy (ectoparasite) - tick NOS[the product did not have the expected effect: ticks]2.4%139 reports
Not eating2.2%128 reports
Anorexia[not eating]2.1%120 reports
Emesis (multiple)[vomiting more than once]2%118 reports
Lack of efficacy (endoparasite) - roundworm NOS[the product did not have the expected effect: roundworms]2%114 reports

Show the next 1 signs

Behavioural disorder NOS[behaviour change, type not specified]1.9%111 reports

Ingredients, all combinations

The list has every active ingredient with 10 or more reports received in August 2021, in order of name. It has 81 ingredients.

Show the 81 ingredients

The same month in other years

Cite this page

Pet Drug Reports. August 2021: adverse event reports for animal drugs. https://petdrugreports.com/month/2021-08/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The month is the month in which FDA received the report, not the month of the event.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this month

Can the count for August 2021 change?: Yes. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
Does the month show when the event occurred?: No. The month is the month in which FDA received the report. The event can be from an earlier month.
Which sign is in the largest number of the reports of the month?: "Vomiting" is in 938 reports of the 5,817 reports of August 2021 (16.1%).