September 2021: adverse event reports that FDA received

Month in which FDA received the reports

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

FDA received 5,310 adverse event reports for animal drugs in September 2021. It received 5,904 reports in September 2020. The average of the 12 months before September 2021 is 5,464 reports for each month.

Of the 5,310 reports, 75.9% are about dogs, 10.5% are about cats and 1.1% are about horses. The other reports are about other species, or give no species. A report is not proof that a drug caused a sign.

Search engines do not list month pages. The site keeps the page, and the list of months links it.

The months before and after

Reports for each month, Mar 2020 to Mar 2022. The column with the outline is September 2021.

Reports by species

Dog75.9%4,029
Cat10.5%558
Horse1.1%57
Other species, or species not given12.5%666

Drug pages with reports received in September 2021

The table has every drug page with 10 or more reports that FDA received in September 2021, in order of name. No count decides which drug is in the table. The table has 70 drug pages.

Show the 70 drug pages

Drug pages with 10 or more reports received in September 2021, in order of name
Active ingredients	Reports received in September 2021
(S) - methoprene	15
Afoxolaner	379
Amoxicillin Trihydrate + Clavulanate Potassium	16
Buprenorphine	15
Butorphanol Tartrate	30
Capromorelin	27
Carprofen	78
Cefovecin sodium	45
Cefpodoxime proxetil	18
Cyclosporine	40
Deslorelin Acetate	12
Dexmedetomidine hydrochloride	25
Diphenhydramine	20
Doxycycline	19
Emodepside + Praziquantel	25
Enrofloxacin	16
Estriol	11
Febantel + Praziquantel + Pyrantel Pamoate	46
Fenbendazole	12
Firocoxib	13
Florfenicol + Mometasone furoate + Terbinafine	42
Fluoxetine hydrochloride	14
Fluralaner	558
Fluralaner + Moxidectin	53
Furosemide	11
Gabapentin	39
Grapiprant	45
Imepitoin	13
Imidacloprid	122
Imidacloprid + Moxidectin	96
Insulin	60
Isoflurane	15
Ivermectin	51
Ivermectin + Praziquantel + Pyrantel Pamoate	15
Ivermectin + Pyrantel Pamoate	738
Lotilaner	117
Lufenuron + Milbemycin Oxime	75
Lufenuron + Milbemycin Oxime + Praziquantel	45
Maropitant	56
Melarsomine Dihydrochloride	80
Meloxicam	29
Metronidazole	17
Milbemycin Oxime	48
Milbemycin Oxime + Praziquantel	317
Milbemycin Oxime + Spinosad	220
Mirtazapine	10
Moxidectin	334
Moxidectin + Pyrantel Pamoate + Sarolaner	10
Nitenpyram	148
Oclacitinib	113
Omeprazole	19
Pimobendan	33
Polysulfated Glycosaminoglycan	31
Praziquantel	20
Praziquantel + Pyrantel Pamoate	18
Prednisolone	11
Prednisone	55
Pyrantel Pamoate	20
Pyrantel Pamoate + Sarolaner	617
Robenacoxib	12
Sarolaner	118
Sarolaner + Selamectin	137
Selamectin	95
Sodium Chloride	43
Spinosad	39
Tigilanol tiglate	29
Trazodone	12
Trilostane	76
Tulathromycin	17
Verdinexor	10

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
Commonly used products may have a higher number of reported adverse events due to the higher total number of animals being given the product.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Signs that the reports of the month list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 5,310 reports of the month.

The sign that is in the largest number of the reports comes first.

Vomiting15.1%804 reports
Lack of efficacy (endoparasite) - heartworm[the product did not have the expected effect: heartworm]12%635 reports
Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]9.3%494 reports
Lethargy[unusually tired or inactive]7.5%398 reports
Lack of efficacy (endoparasite) - hookworm[the product did not have the expected effect: hookworms]7.2%382 reports
Diarrhoea[diarrhea]5.6%300 reports
Seizure NOS[seizure, type not specified]3.9%209 reports
Lack of efficacy (ectoparasite) - tick NOS[the product did not have the expected effect: ticks]2.9%155 reports
Lack of efficacy (endoparasite) - roundworm NOS[the product did not have the expected effect: roundworms]2.6%139 reports
Death2.6%138 reports
Emesis (multiple)[vomiting more than once]2.4%128 reports
Ataxia[unsteady, uncoordinated movement]2.3%122 reports
Lack of efficacy - NOS[the product did not have the expected effect]2.2%118 reports
Behavioural disorder NOS[behaviour change, type not specified]2.1%112 reports

Show the next 1 signs

Not eating2%108 reports

Ingredients, all combinations

The list has every active ingredient with 10 or more reports received in September 2021, in order of name. It has 70 ingredients.

Show the 70 ingredients

The same month in other years

Cite this page

Pet Drug Reports. September 2021: adverse event reports for animal drugs. https://petdrugreports.com/month/2021-09/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The month is the month in which FDA received the report, not the month of the event.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this month

Can the count for September 2021 change?: Yes. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
Does the month show when the event occurred?: No. The month is the month in which FDA received the report. The event can be from an earlier month.
Which sign is in the largest number of the reports of the month?: "Vomiting" is in 804 reports of the 5,310 reports of September 2021 (15.1%).