August 2003: adverse event reports received

1,212 reports in the openFDA release of 28 Sep 2026

Read this first · FDA's caveat, in its words

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources. FDA Center for Veterinary Medicine

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Not veterinary advice. This site lists what was reported to FDA. For an animal that is unwell, contact a veterinarian.

1,212reports received

1,124same month a year earlier+8%

1,072monthly average, preceding 12 months

63.6%concern dogscats 9.7%

FDA's database holds 1,212 adverse event reports received in August 2003, against 1,124 in the same month a year earlier and a monthly average of 1,072 over the preceding 12 months.

63.6% of the month's reports concern dogs, 9.7% cats and 2% horses; the rest concern other species, exposed people, or give no species.

By active ingredient, the drugs named most often were moxidectin (166), deracoxib (148) and selamectin (79), and the terms listed most often were vomiting (194), depression (172) and anorexia (115). Report volume has a seasonal shape, with more reports in the warmer months when parasite products are in heavier use.

The months around it

Drugs named most often, by active ingredient

Active ingredients recorded for the drug	Reports	Share of the month's reports
Moxidectin	166	13.7%
Deracoxib	148	12.2%
Selamectin	79	6.5%
Carprofen	77	6.4%
Ivermectin + Pyrantel Pamoate	59	4.9%
Tepoxalin	54	4.5%
Melarsomine Dihydrochloride	48	4%
Milbemycin Oxime	40	3.3%
Ivermectin	39	3.2%
Enrofloxacin	31	2.6%
Dimethyl Sulfoxide + Fluocinolone Acetonide	30	2.5%
Tilmicosin Phosphate	29	2.4%
Clomipramine Hydrochloride	27	2.2%
Lufenuron + Milbemycin Oxime	26	2.1%
Amoxicillin	25	2.1%

Ordered by report count, which follows how widely each drug was in use. FDA states that these data cannot be used to estimate risk or to compare one product with another. Brand and manufacturer names are masked by FDA in these records.

Signs listed most often

Vomiting16%194
Depression[dull, quiet or withdrawn]14.2%172
Anorexia[not eating]9.5%115
Death9%109
Diarrhoea[diarrhea]8.3%100
Accidental exposure[exposure that was not intended]7.9%96
Death by euthanasia[the animal was euthanized]5.2%63
Elevated serum alkaline phosphatase (SAP)[a liver and bone enzyme above the normal range]5.2%63
Ineffective, heartworm larvae[legacy FDA term: the product did not have the expected effect (heartworm larvae)]5%60
Ataxia[unsteady, uncoordinated movement]4.7%57
Elevated alanine aminotransferase (ALT)[a liver enzyme above the normal range]4.6%56
Elevated blood urea nitrogen (BUN)[a kidney value above the normal range]4.6%56
Unclassifiable adverse event[event that fits no dictionary term]4.2%51
Elevated creatinine[a kidney value above the normal range]4.1%50
Anaphylaxis[sudden severe allergic-type reaction]3.9%47

Single ingredients, pooled

Moxidectin13.8%167

Deracoxib12.2%148

Ivermectin9.9%120

Selamectin6.5%79

Carprofen6.4%77

Pyrantel Pamoate5.5%67

Milbemycin Oxime5.4%66

Tepoxalin4.5%54

Melarsomine Dihydrochloride4%48

Enrofloxacin2.9%35

Lufenuron2.7%33

Dimethyl Sulfoxide2.5%30

Species

Dog63.6%771

Cat9.7%117

Horse2%24

Other or not given24.8%300

Questions about August 2003

How many animal drug adverse event reports did FDA receive in August 2003?

1,212 reports are in the openFDA release of 28 Sep 2026. The same month a year earlier has 1,124.

Which drugs were named most often?

By active ingredient: moxidectin (166), deracoxib (148), selamectin (79), carprofen (77) and ivermectin + pyrantel pamoate (59). Brands are masked in the public data.

Which signs were listed most often?

vomiting (194), depression (172), anorexia (115), death (109) and diarrhoea (100).

Can the count for a month still change?

Yes. FDA posts reports quarterly with a delay of three to six months, so the newest months are incomplete and usually grow in later releases. Older months change little.

Does a busy month mean something went wrong that month?

Not by itself. The date is when FDA received the report, not when the event happened, and volume follows season, product launches and publicity. FDA states that "there is no certainty that the reported drug or device caused the adverse event" and that the event "may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources."

Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 1 Oct 2026. The month is the date FDA first received the report, not the date of the event. No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.