August 1998: adverse event reports received

1,273 reports in the openFDA release of 28 Sep 2026

Read this first · FDA's caveat, in its words

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources. FDA Center for Veterinary Medicine

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Not veterinary advice. This site lists what was reported to FDA. For an animal that is unwell, contact a veterinarian.

1,273reports received

325same month a year earlier+292%

512monthly average, preceding 12 months

59.2%concern dogscats 6.2%

FDA's database holds 1,273 adverse event reports received in August 1998, against 325 in the same month a year earlier and a monthly average of 512 over the preceding 12 months.

59.2% of the month's reports concern dogs, 6.2% cats and 3.3% horses; the rest concern other species, exposed people, or give no species.

By active ingredient, the drugs named most often were carprofen (426), doramectin (222) and betamethasone valerate + clotrimazole + gentamicin sulfate (85), and the terms listed most often were death (153), vomiting (134) and accidental exposure (129). Report volume has a seasonal shape, with more reports in the warmer months when parasite products are in heavier use.

The months around it

Drugs named most often, by active ingredient

Active ingredients recorded for the drug	Reports	Share of the month's reports
Carprofen	426	33.5%
Doramectin	222	17.4%
Betamethasone Valerate + Clotrimazole + Gentamicin Sulfate	85	6.7%
Oxibendazole	69	5.4%
Selegiline Hydrochloride	60	4.7%
Moxidectin	45	3.5%
Sulfadimethoxine	36	2.8%
Melarsomine Dihydrochloride	35	2.7%
Florfenicol	31	2.4%
Medetomidine	26	2%
Penicillin G Procaine	22	1.7%
Atipamezole Hydrochloride	19	1.5%
Lufenuron	17	1.3%
Ivermectin	11	0.9%
Ivermectin + Pyrantel Pamoate	11	0.9%

Ordered by report count, which follows how widely each drug was in use. FDA states that these data cannot be used to estimate risk or to compare one product with another. Brand and manufacturer names are masked by FDA in these records.

Signs listed most often

Death12%153
Vomiting10.5%134
Accidental exposure[exposure that was not intended]10.1%129
Depression[dull, quiet or withdrawn]10%127
Anorexia[not eating]8.2%104
Pruritus[itching]8.2%104
Elevated serum alkaline phosphatase (SAP)[a liver and bone enzyme above the normal range]7.5%95
No sign[no clinical sign was reported]7%89
Elevated alanine aminotransferase (ALT)[a liver enzyme above the normal range]6.8%86
Death by euthanasia[the animal was euthanized]5.7%73
Diarrhoea[diarrhea]5.7%73
Alopecia NOS[hair loss, type not specified]5.4%69
Ineffective, lice biting[legacy FDA term: the product did not have the expected effect (lice biting)]5%64
Deafness4.9%62
Elevated total bilirubin[bilirubin above the normal range]4.2%53

Single ingredients, pooled

Carprofen33.5%426

Doramectin17.4%222

Betamethasone Valerate6.7%85

Clotrimazole6.7%85

Gentamicin Sulfate6.7%85

Oxibendazole5.4%69

Selegiline Hydrochloride4.7%60

Moxidectin3.5%45

Sulfadimethoxine3.4%43

Melarsomine Dihydrochloride2.7%35

Florfenicol2.4%31

Lufenuron2.2%28

Species

Dog59.2%754

Cat6.2%79

Horse3.3%42

Other or not given31.3%398

Questions about August 1998

How many animal drug adverse event reports did FDA receive in August 1998?

1,273 reports are in the openFDA release of 28 Sep 2026. The same month a year earlier has 325.

Which drugs were named most often?

By active ingredient: carprofen (426), doramectin (222), betamethasone valerate + clotrimazole + gentamicin sulfate (85), oxibendazole (69) and selegiline hydrochloride (60). Brands are masked in the public data.

Which signs were listed most often?

death (153), vomiting (134), accidental exposure (129), depression (127) and anorexia (104).

Can the count for a month still change?

Yes. FDA posts reports quarterly with a delay of three to six months, so the newest months are incomplete and usually grow in later releases. Older months change little.

Does a busy month mean something went wrong that month?

Not by itself. The date is when FDA received the report, not when the event happened, and volume follows season, product launches and publicity. FDA states that "there is no certainty that the reported drug or device caused the adverse event" and that the event "may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources."

Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 30 Sep 2026. The month is the date FDA first received the report, not the date of the event. No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.