December 2013: adverse event reports received

4,141 reports in the openFDA release of 28 Sep 2026

Read this first · FDA's caveat, in its words

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources. FDA Center for Veterinary Medicine

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Not veterinary advice. This site lists what was reported to FDA. For an animal that is unwell, contact a veterinarian.

4,141reports received

4,041same month a year earlier+2%

5,770monthly average, preceding 12 months

73.6%concern dogscats 10.2%

FDA's database holds 4,141 adverse event reports received in December 2013, against 4,041 in the same month a year earlier and a monthly average of 5,770 over the preceding 12 months.

73.6% of the month's reports concern dogs, 10.2% cats and 1.2% horses; the rest concern other species, exposed people, or give no species.

By active ingredient, the drugs named most often were milbemycin oxime + spinosad (1,435), spinosad (526) and ivermectin + pyrantel pamoate (462), and the terms listed most often were emesis (1,085), lack of efficacy - NOS (621) and lethargy (511). Report volume has a seasonal shape, with more reports in the warmer months when parasite products are in heavier use.

The months around it

Drugs named most often, by active ingredient

Active ingredients recorded for the drug	Reports	Share of the month's reports
Milbemycin Oxime + Spinosad	1,435	34.7%
Spinosad	526	12.7%
Ivermectin + Pyrantel Pamoate	462	11.2%
Selamectin	160	3.9%
Cyclosporine	122	2.9%
Moxidectin	101	2.4%
Ivermectin	99	2.4%
Lufenuron + Milbemycin Oxime	98	2.4%
Imidacloprid + Moxidectin	95	2.3%
Carprofen	92	2.2%
Ivermectin + Praziquantel + Pyrantel Pamoate	89	2.1%
Insulin	61	1.5%
Melarsomine Dihydrochloride	61	1.5%
Cefovecin sodium	56	1.4%
Prednisone	49	1.2%

Ordered by report count, which follows how widely each drug was in use. FDA states that these data cannot be used to estimate risk or to compare one product with another. Brand and manufacturer names are masked by FDA in these records.

Signs listed most often

Emesis[vomiting]26.2%1,085
Lack of efficacy - NOS[the product did not have the expected effect]15%621
Lethargy[unusually tired or inactive]12.3%511
Vomiting7.5%312
Uncoded sign[a sign with no matching dictionary term]5.8%242
Diarrhoea[diarrhea]5.5%228
Ineffective, heartworm larvae[legacy FDA term: the product did not have the expected effect (heartworm larvae)]5.5%226
Digestive tract disorder NOS[digestive problem, type not specified]4.7%196
Unpalatable[legacy FDA term: the animal would not take it]4.3%178
Ineffective, ascarids NOS[legacy FDA term: the product did not have the expected effect (ascarids nos)]3.8%158
Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]3.8%157
Behavioural disorder NOS[behaviour change, type not specified]3.6%149
Lack of efficacy (endoparasite) - hookworm[the product did not have the expected effect: hookworms]3.5%146
Other abnormal test result NOS[abnormal laboratory result, type not specified]3.3%135
Death3.1%127

Single ingredients, pooled

Spinosad47.2%1,954

Milbemycin Oxime37.2%1,542

Ivermectin16.2%669

Pyrantel Pamoate15.2%628

Praziquantel4.9%203

Moxidectin4.8%197

Selamectin3.9%160

Cyclosporine2.9%122

Lufenuron2.5%103

Imidacloprid2.4%98

Carprofen2.2%92

Insulin1.5%61

Species

Dog73.6%3,049

Cat10.2%421

Horse1.2%51

Other or not given15%620

Questions about December 2013

How many animal drug adverse event reports did FDA receive in December 2013?

4,141 reports are in the openFDA release of 28 Sep 2026. The same month a year earlier has 4,041.

Which drugs were named most often?

By active ingredient: milbemycin oxime + spinosad (1,435), spinosad (526), ivermectin + pyrantel pamoate (462), selamectin (160) and cyclosporine (122). Brands are masked in the public data.

Which signs were listed most often?

emesis (1,085), lack of efficacy - NOS (621), lethargy (511), vomiting (312) and uncoded sign (242).

Can the count for a month still change?

Yes. FDA posts reports quarterly with a delay of three to six months, so the newest months are incomplete and usually grow in later releases. Older months change little.

Does a busy month mean something went wrong that month?

Not by itself. The date is when FDA received the report, not when the event happened, and volume follows season, product launches and publicity. FDA states that "there is no certainty that the reported drug or device caused the adverse event" and that the event "may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources."

Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 1 Oct 2026. The month is the date FDA first received the report, not the date of the event. No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.