December 2024: adverse event reports received

5,701 reports in the openFDA release of 28 Sep 2026

Read this first · FDA's caveat, in its words

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources. FDA Center for Veterinary Medicine

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Not veterinary advice. This site lists what was reported to FDA. For an animal that is unwell, contact a veterinarian.

5,701reports received

4,825same month a year earlier+18%

6,694monthly average, preceding 12 months

68.4%concern dogscats 18.8%

FDA's database holds 5,701 adverse event reports received in December 2024, against 4,825 in the same month a year earlier and a monthly average of 6,694 over the preceding 12 months.

68.4% of the month's reports concern dogs, 18.8% cats and 1.2% horses; the rest concern other species, exposed people, or give no species.

By active ingredient, the drugs named most often were bedinvetmab (925), pyrantel pamoate + sarolaner (656) and fluralaner (339), and the terms listed most often were vomiting (558), lethargy (461) and lack of efficacy - NOS (398). Report volume has a seasonal shape, with more reports in the warmer months when parasite products are in heavier use.

The months around it

Drugs named most often, by active ingredient

Active ingredients recorded for the drug	Reports	Share of the month's reports
Bedinvetmab	925	16.2%
Pyrantel Pamoate + Sarolaner	656	11.5%
Fluralaner	339	5.9%
Gabapentin	310	5.4%
Ivermectin + Pyrantel Pamoate	304	5.3%
Moxidectin	269	4.7%
Carprofen	253	4.4%
Oclacitinib	252	4.4%
Afoxolaner + Moxidectin + Pyrantel Pamoate	242	4.2%
Afoxolaner	236	4.1%
Isoflurane	234	4.1%
Frunevetmab	209	3.7%
Maropitant	179	3.1%
Milbemycin Oxime + Praziquantel	167	2.9%
Velagliflozin	160	2.8%

Ordered by report count, which follows how widely each drug was in use. FDA states that these data cannot be used to estimate risk or to compare one product with another. Brand and manufacturer names are masked by FDA in these records.

Signs listed most often

Vomiting9.8%558
Lethargy[unusually tired or inactive]8.1%461
Lack of efficacy - NOS[the product did not have the expected effect]7%398
Lack of efficacy (endoparasite) - heartworm[the product did not have the expected effect: heartworm]6.9%392
Diarrhoea[diarrhea]5.7%324
Death by euthanasia[the animal was euthanized]5.1%292
Seizure NOS[seizure, type not specified]4.7%269
Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]4.6%264
Lack of efficacy (bacteria) - Borrelia[the product did not have the expected effect: Borrelia (Lyme disease bacteria)]4.4%249
Not eating4.2%242
Death4.1%235
Intentional misuse[use that was knowingly different from the label]3.5%201
Lack of efficacy (endoparasite) - hookworm[the product did not have the expected effect: hookworms]3.4%194
Medication error NOS[a mistake in giving the product, type not specified]3.3%187
Weight loss3.2%183

Single ingredients, pooled

Pyrantel Pamoate22.3%1,271

Bedinvetmab16.2%925

Sarolaner14.5%825

Moxidectin10.5%599

Afoxolaner8%456

Praziquantel7.5%430

Fluralaner6.5%370

Ivermectin5.9%334

Milbemycin Oxime5.8%331

Gabapentin5.4%310

Carprofen4.4%253

Oclacitinib4.4%252

Species

Dog68.4%3,901

Cat18.8%1,070

Horse1.2%67

Other or not given11.6%663

Questions about December 2024

How many animal drug adverse event reports did FDA receive in December 2024?

5,701 reports are in the openFDA release of 28 Sep 2026. The same month a year earlier has 4,825.

Which drugs were named most often?

By active ingredient: bedinvetmab (925), pyrantel pamoate + sarolaner (656), fluralaner (339), gabapentin (310) and ivermectin + pyrantel pamoate (304). Brands are masked in the public data.

Which signs were listed most often?

vomiting (558), lethargy (461), lack of efficacy - NOS (398), lack of efficacy (endoparasite) - heartworm (392) and diarrhoea (324).

Can the count for a month still change?

Yes. FDA posts reports quarterly with a delay of three to six months, so the newest months are incomplete and usually grow in later releases. Older months change little.

Does a busy month mean something went wrong that month?

Not by itself. The date is when FDA received the report, not when the event happened, and volume follows season, product launches and publicity. FDA states that "there is no certainty that the reported drug or device caused the adverse event" and that the event "may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources."

Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 1 Oct 2026. The month is the date FDA first received the report, not the date of the event. No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.