December 2001: adverse event reports received

900 reports in the openFDA release of 28 Sep 2026

Read this first · FDA's caveat, in its words

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources. FDA Center for Veterinary Medicine

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900reports received

814same month a year earlier+11%

1,260monthly average, preceding 12 months

58.2%concern dogscats 12.7%

FDA's database holds 900 adverse event reports received in December 2001, against 814 in the same month a year earlier and a monthly average of 1,260 over the preceding 12 months.

58.2% of the month's reports concern dogs, 12.7% cats and 5.3% horses; the rest concern other species, exposed people, or give no species.

By active ingredient, the drugs named most often were selamectin (229), carprofen (116) and moxidectin (110), and the terms listed most often were vomiting (112), depression (105) and accidental exposure (90). Report volume has a seasonal shape, with more reports in the warmer months when parasite products are in heavier use.

The months around it

Drugs named most often, by active ingredient

Active ingredients recorded for the drug	Reports	Share of the month's reports
Selamectin	229	25.4%
Carprofen	116	12.9%
Moxidectin	110	12.2%
Etodolac	40	4.4%
(S) - methoprene	40	4.4%
Ivermectin	28	3.1%
Milbemycin Oxime	26	2.9%
Ketamine Hydrochloride	22	2.4%
Tilmicosin Phosphate	17	1.9%
Ivermectin + Pyrantel Pamoate	15	1.7%
Melarsomine Dihydrochloride	14	1.6%
Amoxicillin	12	1.3%
Enrofloxacin	12	1.3%
Lufenuron + Milbemycin Oxime	11	1.2%
Pyrantel Pamoate	11	1.2%

Ordered by report count, which follows how widely each drug was in use. FDA states that these data cannot be used to estimate risk or to compare one product with another. Brand and manufacturer names are masked by FDA in these records.

Signs listed most often

Vomiting12.4%112
Depression[dull, quiet or withdrawn]11.7%105
Accidental exposure[exposure that was not intended]10%90
Anorexia[not eating]8.7%78
Ineffective, heartworm larvae[legacy FDA term: the product did not have the expected effect (heartworm larvae)]8.4%76
Death7.8%70
Unclassifiable adverse event[event that fits no dictionary term]6.6%59
Diarrhoea[diarrhea]5.9%53
No sign[no clinical sign was reported]5.6%50
Anaphylaxis[sudden severe allergic-type reaction]5.1%46
Ataxia[unsteady, uncoordinated movement]4.7%42
Death by euthanasia[the animal was euthanized]4.6%41
Convulsion[seizure]3.8%34
Tubes, Abnormal[a product quality report, not a sign in an animal]3.6%32
Pruritus[itching]3.2%29

Single ingredients, pooled

Selamectin25.4%229

Carprofen12.9%116

Moxidectin12.2%110

Ivermectin4.8%43

Etodolac4.4%40

(S) - methoprene4.4%40

Milbemycin Oxime4.1%37

Pyrantel Pamoate3.2%29

Ketamine Hydrochloride2.4%22

Tilmicosin Phosphate1.9%17

Lufenuron1.8%16

Enrofloxacin1.7%15

Species

Dog58.2%524

Cat12.7%114

Horse5.3%48

Other or not given23.8%214

Questions about December 2001

How many animal drug adverse event reports did FDA receive in December 2001?

900 reports are in the openFDA release of 28 Sep 2026. The same month a year earlier has 814.

Which drugs were named most often?

By active ingredient: selamectin (229), carprofen (116), moxidectin (110), etodolac (40) and (s) - methoprene (40). Brands are masked in the public data.

Which signs were listed most often?

vomiting (112), depression (105), accidental exposure (90), anorexia (78) and ineffective, heartworm larvae (76).

Can the count for a month still change?

Yes. FDA posts reports quarterly with a delay of three to six months, so the newest months are incomplete and usually grow in later releases. Older months change little.

Does a busy month mean something went wrong that month?

Not by itself. The date is when FDA received the report, not when the event happened, and volume follows season, product launches and publicity. FDA states that "there is no certainty that the reported drug or device caused the adverse event" and that the event "may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources."

Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 1 Oct 2026. The month is the date FDA first received the report, not the date of the event. No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.