December 1999: adverse event reports received

926 reports in the openFDA release of 28 Sep 2026

Read this first · FDA's caveat, in its words

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources. FDA Center for Veterinary Medicine

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Not veterinary advice. This site lists what was reported to FDA. For an animal that is unwell, contact a veterinarian.

926reports received

3,078same month a year earlier-70%

1,137monthly average, preceding 12 months

60.4%concern dogscats 13.3%

FDA's database holds 926 adverse event reports received in December 1999, against 3,078 in the same month a year earlier and a monthly average of 1,137 over the preceding 12 months.

60.4% of the month's reports concern dogs, 13.3% cats and 2.4% horses; the rest concern other species, exposed people, or give no species.

By active ingredient, the drugs named most often were carprofen (331), selamectin (84) and ormetoprim + sulfadimethoxine (47), and the terms listed most often were accidental exposure (149), vomiting (118) and anorexia (100). Report volume has a seasonal shape, with more reports in the warmer months when parasite products are in heavier use.

The months around it

Drugs named most often, by active ingredient

Active ingredients recorded for the drug	Reports	Share of the month's reports
Carprofen	331	35.7%
Selamectin	84	9.1%
Ormetoprim + Sulfadimethoxine	47	5.1%
Ketamine Hydrochloride	31	3.3%
Clomipramine Hydrochloride	27	2.9%
Selegiline Hydrochloride	25	2.7%
Tilmicosin Phosphate	25	2.7%
Enrofloxacin	20	2.2%
Milbemycin Oxime	20	2.2%
Zeranol	20	2.2%
Lufenuron + Milbemycin Oxime	19	2.1%
Amoxicillin	18	1.9%
Ivermectin	17	1.8%
Melarsomine Dihydrochloride	17	1.8%
Epsiprantel	16	1.7%

Ordered by report count, which follows how widely each drug was in use. FDA states that these data cannot be used to estimate risk or to compare one product with another. Brand and manufacturer names are masked by FDA in these records.

Signs listed most often

Accidental exposure[exposure that was not intended]16.1%149
Vomiting12.7%118
Anorexia[not eating]10.8%100
Depression[dull, quiet or withdrawn]10.7%99
No sign[no clinical sign was reported]10.4%96
Elevated alanine aminotransferase (ALT)[a liver enzyme above the normal range]8.6%80
Elevated serum alkaline phosphatase (SAP)[a liver and bone enzyme above the normal range]8.3%77
Death7.1%66
Diarrhoea[diarrhea]5.8%54
Ataxia[unsteady, uncoordinated movement]4.9%45
Elevated total bilirubin[bilirubin above the normal range]4%37
Unclassifiable adverse event[event that fits no dictionary term]3.9%36
Convulsion[seizure]3.5%32
Trembling2.8%26
Elevated creatinine[a kidney value above the normal range]2.7%25

Single ingredients, pooled

Carprofen35.7%331

Selamectin9.1%84

Sulfadimethoxine5.5%51

Ormetoprim5.1%47

Milbemycin Oxime4.2%39

Ketamine Hydrochloride3.3%31

Lufenuron3.3%31

Clomipramine Hydrochloride2.9%27

Ivermectin2.8%26

Selegiline Hydrochloride2.7%25

Tilmicosin Phosphate2.7%25

Enrofloxacin2.2%20

Species

Dog60.4%559

Cat13.3%123

Horse2.4%22

Other or not given24%222

Questions about December 1999

How many animal drug adverse event reports did FDA receive in December 1999?

926 reports are in the openFDA release of 28 Sep 2026. The same month a year earlier has 3,078.

Which drugs were named most often?

By active ingredient: carprofen (331), selamectin (84), ormetoprim + sulfadimethoxine (47), ketamine hydrochloride (31) and clomipramine hydrochloride (27). Brands are masked in the public data.

Which signs were listed most often?

accidental exposure (149), vomiting (118), anorexia (100), depression (99) and no sign (96).

Can the count for a month still change?

Yes. FDA posts reports quarterly with a delay of three to six months, so the newest months are incomplete and usually grow in later releases. Older months change little.

Does a busy month mean something went wrong that month?

Not by itself. The date is when FDA received the report, not when the event happened, and volume follows season, product launches and publicity. FDA states that "there is no certainty that the reported drug or device caused the adverse event" and that the event "may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources."

Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 1 Oct 2026. The month is the date FDA first received the report, not the date of the event. No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.