December 2022: adverse event reports that FDA received

Month in which FDA received the reports

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

FDA received 3,925 adverse event reports for animal drugs in December 2022. It received 3,657 reports in December 2021. The average of the 12 months before December 2022 is 4,869 reports for each month.

Of the 3,925 reports, 68.9% are about dogs, 14.9% are about cats and 1.2% are about horses. The other reports are about other species, or give no species. A report is not proof that a drug caused a sign.

Search engines do not list month pages. The site keeps the page, and the list of months links it.

The months before and after

Reports for each month, Jun 2021 to Jun 2023. The column with the outline is December 2022.

Reports by species

Dog68.9%2,703
Cat14.9%584
Horse1.2%46
Other species, or species not given15.1%592

Drug pages with reports received in December 2022

The table has every drug page with 10 or more reports that FDA received in December 2022, in order of name. No count decides which drug is in the table. The table has 70 drug pages.

Show the 70 drug pages

Drug pages with 10 or more reports received in December 2022, in order of name
Active ingredients	Reports received in December 2022
Acepromazine Maleate	11
Afoxolaner	193
Amoxicillin Trihydrate + Clavulanate Potassium	17
Atipamezole Hydrochloride	14
Buprenorphine	150
Butorphanol Tartrate	40
Capromorelin	22
Carprofen	79
Cefovecin sodium	57
Ceftiofur Crystalline Free Acid	12
Clotrimazole + Gentamicin	10
Cyclosporine	39
Dexamethasone	10
Dexmedetomidine	32
Dexmedetomidine hydrochloride	16
Diphenhydramine	17
Doxycycline	18
Emodepside + Praziquantel	21
Famotidine	16
Febantel + Praziquantel + Pyrantel Pamoate	30
Florfenicol + Mometasone furoate + Terbinafine	56
Fluralaner	250
Fluralaner + Moxidectin	29
Frunevetmab	131
Gabapentin	70
Grapiprant	45
Imidacloprid	45
Imidacloprid + Moxidectin	46
Insulin	50
Isoflurane	42
Ivermectin	31
Ivermectin + Pyrantel Pamoate	450
Ketamine Hydrochloride	27
Lotilaner	75
Lufenuron + Milbemycin Oxime	34
Lufenuron + Milbemycin Oxime + Praziquantel	30
Maropitant	88
Melarsomine Dihydrochloride	76
Meloxicam	41
Methimazole	14
Midazolam	11
Milbemycin Oxime	28
Milbemycin Oxime + Praziquantel	175
Milbemycin Oxime + Spinosad	111
Mirtazapine	15
Monensin	13
Moxidectin	276
Moxidectin + Pyrantel Pamoate + Sarolaner	12
Nitenpyram	85
Oclacitinib	84
Omeprazole	16
Pimobendan	68
Polysulfated Glycosaminoglycan	23
Praziquantel	23
Praziquantel + Pyrantel Pamoate	22
Prednisolone	18
Prednisone	51
Propofol	38
Pyrantel Pamoate	22
Pyrantel Pamoate + Sarolaner	650
Robenacoxib	30
Sarolaner	61
Sarolaner + Selamectin	75
Selamectin	53
Sodium Chloride	93
Spinosad	12
Tigilanol tiglate	36
Tramadol	11
Trilostane	66
Verdinexor	11

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
Commonly used products may have a higher number of reported adverse events due to the higher total number of animals being given the product.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Signs that the reports of the month list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 3,925 reports of the month.

The sign that is in the largest number of the reports comes first.

Vomiting12.6%495 reports
Lack of efficacy (endoparasite) - heartworm[the product did not have the expected effect: heartworm]12.1%476 reports
Lethargy[unusually tired or inactive]7.1%279 reports
Lack of efficacy (endoparasite) - hookworm[the product did not have the expected effect: hookworms]5.7%222 reports
Diarrhoea[diarrhea]5%196 reports
Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]4%157 reports
Seizure NOS[seizure, type not specified]3.9%153 reports
Lack of efficacy (endoparasite) - roundworm NOS[the product did not have the expected effect: roundworms]3.8%150 reports
Lack of efficacy (ectoparasite) - tick NOS[the product did not have the expected effect: ticks]3.3%131 reports
Containers, Damaged[a product quality report, not a sign in an animal]3.3%130 reports
Death3.1%122 reports
Lack of efficacy (bacteria) - Borrelia[the product did not have the expected effect: Borrelia (Lyme disease bacteria)]3%117 reports
Lack of efficacy - NOS[the product did not have the expected effect]2.9%114 reports
Not eating2.9%113 reports

Show the next 1 signs

Behavioural disorder NOS[behaviour change, type not specified]2.8%108 reports

Ingredients, all combinations

The list has every active ingredient with 10 or more reports received in December 2022, in order of name. It has 69 ingredients.

Show the 69 ingredients

The same month in other years

Cite this page

Pet Drug Reports. December 2022: adverse event reports for animal drugs. https://petdrugreports.com/month/2022-12/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The month is the month in which FDA received the report, not the month of the event.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this month

Can the count for December 2022 change?: Yes. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
Does the month show when the event occurred?: No. The month is the month in which FDA received the report. The event can be from an earlier month.
Which sign is in the largest number of the reports of the month?: "Vomiting" is in 495 reports of the 3,925 reports of December 2022 (12.6%).