June 2019: adverse event reports received

6,991 reports in the openFDA release of 28 Sep 2026

Read this first · FDA's caveat, in its words

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources. FDA Center for Veterinary Medicine

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6,991reports received

7,191same month a year earlier-3%

6,061monthly average, preceding 12 months

75.4%concern dogscats 10.1%

FDA's database holds 6,991 adverse event reports received in June 2019, against 7,191 in the same month a year earlier and a monthly average of 6,061 over the preceding 12 months.

75.4% of the month's reports concern dogs, 10.1% cats and 0.6% horses; the rest concern other species, exposed people, or give no species.

By active ingredient, the drugs named most often were fluralaner (1,151), ivermectin + pyrantel pamoate (1,026) and afoxolaner (620), and the terms listed most often were vomiting (1,341), lack of efficacy (endoparasite) - heartworm (645) and lethargy (632). Report volume has a seasonal shape, with more reports in the warmer months when parasite products are in heavier use.

The months around it

Drugs named most often, by active ingredient

Active ingredients recorded for the drug	Reports	Share of the month's reports
Fluralaner	1,151	16.5%
Ivermectin + Pyrantel Pamoate	1,026	14.7%
Afoxolaner	620	8.9%
Milbemycin Oxime + Spinosad	564	8.1%
Milbemycin Oxime + Praziquantel	450	6.4%
Sarolaner	340	4.9%
Moxidectin	327	4.7%
Selamectin	187	2.7%
Lotilaner	165	2.4%
Imidacloprid + Moxidectin	162	2.3%
Lufenuron + Milbemycin Oxime	153	2.2%
Oclacitinib	149	2.1%
Nitenpyram	146	2.1%
Spinosad	132	1.9%
Sarolaner + Selamectin	112	1.6%

Ordered by report count, which follows how widely each drug was in use. FDA states that these data cannot be used to estimate risk or to compare one product with another. Brand and manufacturer names are masked by FDA in these records.

Signs listed most often

Vomiting19.2%1,341
Lack of efficacy (endoparasite) - heartworm[the product did not have the expected effect: heartworm]9.2%645
Lethargy[unusually tired or inactive]9%632
Ineffective, hooks[legacy FDA term: the product did not have the expected effect (hooks)]6.1%424
Diarrhoea[diarrhea]6%420
Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]5.6%389
Seizure NOS[seizure, type not specified]3.5%244
Product problem[a product quality report, not a sign in an animal]3.2%224
Unpalatable[legacy FDA term: the animal would not take it]2.8%196
Death2.6%179
Lack of efficacy (tick)[the product did not have the expected effect: ticks]2.4%168
Lack of efficacy (ectoparasite) - tick NOS[the product did not have the expected effect: ticks]2.4%166
Anorexia[not eating]2.4%165
Emesis (multiple)[vomiting more than once]2.3%164
Lack of efficacy (flea)[the product did not have the expected effect: fleas]2.3%161

Single ingredients, pooled

Milbemycin Oxime18.6%1,301

Fluralaner16.5%1,151

Pyrantel Pamoate16.3%1,142

Ivermectin16%1,119

Praziquantel10.3%722

Spinosad9.9%690

Afoxolaner8.9%620

Moxidectin7%488

Sarolaner6.5%452

Selamectin4.2%295

Lufenuron3.7%258

Imidacloprid3.1%220

Species

Dog75.4%5,269

Cat10.1%705

Horse0.6%45

Other or not given13.9%972

Questions about June 2019

How many animal drug adverse event reports did FDA receive in June 2019?

6,991 reports are in the openFDA release of 28 Sep 2026. The same month a year earlier has 7,191.

Which drugs were named most often?

By active ingredient: fluralaner (1,151), ivermectin + pyrantel pamoate (1,026), afoxolaner (620), milbemycin oxime + spinosad (564) and milbemycin oxime + praziquantel (450). Brands are masked in the public data.

Which signs were listed most often?

vomiting (1,341), lack of efficacy (endoparasite) - heartworm (645), lethargy (632), ineffective, hooks (424) and diarrhoea (420).

Can the count for a month still change?

Yes. FDA posts reports quarterly with a delay of three to six months, so the newest months are incomplete and usually grow in later releases. Older months change little.

Does a busy month mean something went wrong that month?

Not by itself. The date is when FDA received the report, not when the event happened, and volume follows season, product launches and publicity. FDA states that "there is no certainty that the reported drug or device caused the adverse event" and that the event "may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources."

Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 1 Oct 2026. The month is the date FDA first received the report, not the date of the event. No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.