June 2003: adverse event reports received

1,491 reports in the openFDA release of 28 Sep 2026

Read this first · FDA's caveat, in its words

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources. FDA Center for Veterinary Medicine

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1,491reports received

1,268same month a year earlier+18%

1,064monthly average, preceding 12 months

69.8%concern dogscats 6.6%

FDA's database holds 1,491 adverse event reports received in June 2003, against 1,268 in the same month a year earlier and a monthly average of 1,064 over the preceding 12 months.

69.8% of the month's reports concern dogs, 6.6% cats and 1.8% horses; the rest concern other species, exposed people, or give no species.

By active ingredient, the drugs named most often were moxidectin (280), ivermectin + pyrantel pamoate (174) and ivermectin (145), and the terms listed most often were vomiting (199), depression (168) and ineffective, heartworm larvae (160). Report volume has a seasonal shape, with more reports in the warmer months when parasite products are in heavier use.

The months around it

Drugs named most often, by active ingredient

Active ingredients recorded for the drug	Reports	Share of the month's reports
Moxidectin	280	18.8%
Ivermectin + Pyrantel Pamoate	174	11.7%
Ivermectin	145	9.7%
Deracoxib	135	9.1%
Selamectin	115	7.7%
Melarsomine Dihydrochloride	92	6.2%
Carprofen	59	4%
Tepoxalin	34	2.3%
Milbemycin Oxime	22	1.5%
Selegiline Hydrochloride	21	1.4%
Tilmicosin Phosphate	20	1.3%
Butorphanol Tartrate	18	1.2%
Clomipramine Hydrochloride	17	1.1%
Tiletamine Hydrochloride + Zolazepam Hydrochloride	17	1.1%
Amoxicillin	16	1.1%

Ordered by report count, which follows how widely each drug was in use. FDA states that these data cannot be used to estimate risk or to compare one product with another. Brand and manufacturer names are masked by FDA in these records.

Signs listed most often

Vomiting13.3%199
Depression[dull, quiet or withdrawn]11.3%168
Ineffective, heartworm larvae[legacy FDA term: the product did not have the expected effect (heartworm larvae)]10.7%160
Death8.7%129
Anorexia[not eating]8.5%127
Accidental exposure[exposure that was not intended]6.6%98
Ataxia[unsteady, uncoordinated movement]6.5%97
Diarrhoea[diarrhea]5.9%88
Convulsion[seizure]4.7%70
Unclassifiable adverse event[event that fits no dictionary term]4.6%68
Death by euthanasia[the animal was euthanized]3.8%56
Elevated blood urea nitrogen (BUN)[a kidney value above the normal range]3.8%56
Fever3.7%55
Anaphylaxis[sudden severe allergic-type reaction]3.6%54
Lack of efficacy (endoparasite) - hookworm[the product did not have the expected effect: hookworms]3.4%50

Single ingredients, pooled

Ivermectin21.9%326

Moxidectin18.8%280

Pyrantel Pamoate11.8%176

Deracoxib9.1%135

Selamectin7.7%115

Melarsomine Dihydrochloride6.2%92

Carprofen4%59

Tepoxalin2.3%34

Milbemycin Oxime1.8%27

Selegiline Hydrochloride1.4%21

Tilmicosin Phosphate1.3%20

Butorphanol Tartrate1.2%18

Species

Dog69.8%1,040

Cat6.6%98

Horse1.8%27

Other or not given21.9%326

Questions about June 2003

How many animal drug adverse event reports did FDA receive in June 2003?

1,491 reports are in the openFDA release of 28 Sep 2026. The same month a year earlier has 1,268.

Which drugs were named most often?

By active ingredient: moxidectin (280), ivermectin + pyrantel pamoate (174), ivermectin (145), deracoxib (135) and selamectin (115). Brands are masked in the public data.

Which signs were listed most often?

vomiting (199), depression (168), ineffective, heartworm larvae (160), death (129) and anorexia (127).

Can the count for a month still change?

Yes. FDA posts reports quarterly with a delay of three to six months, so the newest months are incomplete and usually grow in later releases. Older months change little.

Does a busy month mean something went wrong that month?

Not by itself. The date is when FDA received the report, not when the event happened, and volume follows season, product launches and publicity. FDA states that "there is no certainty that the reported drug or device caused the adverse event" and that the event "may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources."

Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 1 Oct 2026. The month is the date FDA first received the report, not the date of the event. No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.