June 2000: adverse event reports received

3,621 reports in the openFDA release of 28 Sep 2026

Read this first · FDA's caveat, in its words

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources. FDA Center for Veterinary Medicine

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Not veterinary advice. This site lists what was reported to FDA. For an animal that is unwell, contact a veterinarian.

3,621reports received

958same month a year earlier+278%

1,213monthly average, preceding 12 months

72.6%concern dogscats 12.5%

FDA's database holds 3,621 adverse event reports received in June 2000, against 958 in the same month a year earlier and a monthly average of 1,213 over the preceding 12 months.

72.6% of the month's reports concern dogs, 12.5% cats and 0.8% horses; the rest concern other species, exposed people, or give no species.

By active ingredient, the drugs named most often were selamectin (2,012), selegiline hydrochloride (714) and carprofen (398), and the terms listed most often were lack of efficacy (ectoparasite) - flea (526), vomiting (452) and depression (361). Report volume has a seasonal shape, with more reports in the warmer months when parasite products are in heavier use.

The months around it

Drugs named most often, by active ingredient

Active ingredients recorded for the drug	Reports	Share of the month's reports
Selamectin	2,012	55.6%
Selegiline Hydrochloride	714	19.7%
Carprofen	398	11%
Milbemycin Oxime	50	1.4%
Lufenuron + Milbemycin Oxime	40	1.1%
(S) - methoprene	38	1%
Etodolac	32	0.9%
Moxidectin	25	0.7%
Amoxicillin	23	0.6%
Diethylcarbamazine Citrate	23	0.6%
Enrofloxacin	16	0.4%
Atipamezole Hydrochloride	15	0.4%
Ivermectin	14	0.4%
Lufenuron	14	0.4%
Sulfadimethoxine	13	0.4%

Ordered by report count, which follows how widely each drug was in use. FDA states that these data cannot be used to estimate risk or to compare one product with another. Brand and manufacturer names are masked by FDA in these records.

Signs listed most often

Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]14.5%526
Vomiting12.5%452
Depression[dull, quiet or withdrawn]10%361
Lack of efficacy (ectoparasite) - tick NOS[the product did not have the expected effect: ticks]9%326
Anorexia[not eating]8.8%318
Diarrhoea[diarrhea]8.2%298
Accidental exposure[exposure that was not intended]5.2%187
Pruritus[itching]4.6%166
No sign[no clinical sign was reported]4.2%151
Elevated serum alkaline phosphatase (SAP)[a liver and bone enzyme above the normal range]3.2%115
Application site alopecia[hair loss where the product was applied]3.1%114
Death3.1%111
Ineffective, loss of effect[legacy FDA term: the product did not have the expected effect (loss of effect)]3%108
Convulsion[seizure]2.9%104
Elevated alanine aminotransferase (ALT)[a liver enzyme above the normal range]2.8%103

Single ingredients, pooled

Selamectin55.6%2,012

Selegiline Hydrochloride19.7%714

Carprofen11%398

Milbemycin Oxime2.5%90

Lufenuron1.5%54

(S) - methoprene1%38

Etodolac0.9%32

Moxidectin0.7%25

Amoxicillin0.6%23

Diethylcarbamazine Citrate0.6%23

Enrofloxacin0.4%16

Ivermectin0.4%16

Species

Dog72.6%2,629

Cat12.5%452

Horse0.8%30

Other or not given14.1%510

Questions about June 2000

How many animal drug adverse event reports did FDA receive in June 2000?

3,621 reports are in the openFDA release of 28 Sep 2026. The same month a year earlier has 958.

Which drugs were named most often?

By active ingredient: selamectin (2,012), selegiline hydrochloride (714), carprofen (398), milbemycin oxime (50) and lufenuron + milbemycin oxime (40). Brands are masked in the public data.

Which signs were listed most often?

lack of efficacy (ectoparasite) - flea (526), vomiting (452), depression (361), lack of efficacy (ectoparasite) - tick NOS (326) and anorexia (318).

Can the count for a month still change?

Yes. FDA posts reports quarterly with a delay of three to six months, so the newest months are incomplete and usually grow in later releases. Older months change little.

Does a busy month mean something went wrong that month?

Not by itself. The date is when FDA received the report, not when the event happened, and volume follows season, product launches and publicity. FDA states that "there is no certainty that the reported drug or device caused the adverse event" and that the event "may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources."

Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 1 Oct 2026. The month is the date FDA first received the report, not the date of the event. No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.