March 2025: adverse event reports received

4,937 reports in the openFDA release of 28 Sep 2026

Read this first · FDA's caveat, in its words

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources. FDA Center for Veterinary Medicine

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Not veterinary advice. This site lists what was reported to FDA. For an animal that is unwell, contact a veterinarian.

4,937reports received

6,461same month a year earlier-24%

6,735monthly average, preceding 12 months

67.9%concern dogscats 16.7%

FDA's database holds 4,937 adverse event reports received in March 2025, against 6,461 in the same month a year earlier and a monthly average of 6,735 over the preceding 12 months.

67.9% of the month's reports concern dogs, 16.7% cats and 0.9% horses; the rest concern other species, exposed people, or give no species.

By active ingredient, the drugs named most often were pyrantel pamoate + sarolaner (711), bedinvetmab (477) and fluralaner (307), and the terms listed most often were vomiting (529), lethargy (422) and lack of efficacy (endoparasite) - heartworm (383). Report volume has a seasonal shape, with more reports in the warmer months when parasite products are in heavier use.

The months around it

Drugs named most often, by active ingredient

Active ingredients recorded for the drug	Reports	Share of the month's reports
Pyrantel Pamoate + Sarolaner	711	14.4%
Bedinvetmab	477	9.7%
Fluralaner	307	6.2%
Ivermectin + Pyrantel Pamoate	296	6%
Moxidectin	282	5.7%
Afoxolaner + Moxidectin + Pyrantel Pamoate	256	5.2%
Milbemycin Oxime + Praziquantel	194	3.9%
Oclacitinib	186	3.8%
Afoxolaner	172	3.5%
Gabapentin	170	3.4%
Carprofen	161	3.3%
Maropitant	157	3.2%
Frunevetmab	147	3%
Velagliflozin	126	2.6%
Lotilaner	109	2.2%

Ordered by report count, which follows how widely each drug was in use. FDA states that these data cannot be used to estimate risk or to compare one product with another. Brand and manufacturer names are masked by FDA in these records.

Signs listed most often

Vomiting10.7%529
Lethargy[unusually tired or inactive]8.5%422
Lack of efficacy (endoparasite) - heartworm[the product did not have the expected effect: heartworm]7.8%383
Diarrhoea[diarrhea]5.6%276
Lack of efficacy - NOS[the product did not have the expected effect]5.3%264
Lack of efficacy (bacteria) - Borrelia[the product did not have the expected effect: Borrelia (Lyme disease bacteria)]5.1%250
Lack of efficacy (endoparasite) - hookworm[the product did not have the expected effect: hookworms]4.8%238
Seizure NOS[seizure, type not specified]4.1%204
Medication error NOS[a mistake in giving the product, type not specified]3.9%194
Lack of efficacy (endoparasite) - roundworm NOS[the product did not have the expected effect: roundworms]3.7%182
Death3.6%179
Death by euthanasia[the animal was euthanized]3.5%173
Not eating3.4%168
Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]3.3%164
Weight loss3%149

Single ingredients, pooled

Pyrantel Pamoate27.1%1,340

Sarolaner17.6%867

Moxidectin13.1%647

Bedinvetmab9.7%477

Afoxolaner8.5%418

Praziquantel8.2%407

Fluralaner7.3%359

Milbemycin Oxime7.2%355

Ivermectin6.7%332

Oclacitinib3.8%186

Gabapentin3.5%171

Carprofen3.3%161

Species

Dog67.9%3,353

Cat16.7%824

Horse0.9%43

Other or not given14.5%717

Questions about March 2025

How many animal drug adverse event reports did FDA receive in March 2025?

4,937 reports are in the openFDA release of 28 Sep 2026. The same month a year earlier has 6,461.

Which drugs were named most often?

By active ingredient: pyrantel pamoate + sarolaner (711), bedinvetmab (477), fluralaner (307), ivermectin + pyrantel pamoate (296) and moxidectin (282). Brands are masked in the public data.

Which signs were listed most often?

vomiting (529), lethargy (422), lack of efficacy (endoparasite) - heartworm (383), diarrhoea (276) and lack of efficacy - NOS (264).

Can the count for a month still change?

Yes. FDA posts reports quarterly with a delay of three to six months, so the newest months are incomplete and usually grow in later releases. Older months change little.

Does a busy month mean something went wrong that month?

Not by itself. The date is when FDA received the report, not when the event happened, and volume follows season, product launches and publicity. FDA states that "there is no certainty that the reported drug or device caused the adverse event" and that the event "may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources."

Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 1 Oct 2026. The month is the date FDA first received the report, not the date of the event. No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.