March 2014: adverse event reports received

5,032 reports in the openFDA release of 28 Sep 2026

Read this first · FDA's caveat, in its words

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources. FDA Center for Veterinary Medicine

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Not veterinary advice. This site lists what was reported to FDA. For an animal that is unwell, contact a veterinarian.

5,032reports received

5,164same month a year earlier-3%

5,704monthly average, preceding 12 months

76.1%concern dogscats 9%

FDA's database holds 5,032 adverse event reports received in March 2014, against 5,164 in the same month a year earlier and a monthly average of 5,704 over the preceding 12 months.

76.1% of the month's reports concern dogs, 9% cats and 0.7% horses; the rest concern other species, exposed people, or give no species.

By active ingredient, the drugs named most often were milbemycin oxime + spinosad (1,469), ivermectin + pyrantel pamoate (643) and spinosad (508), and the terms listed most often were emesis (1,114), lack of efficacy - NOS (822) and lethargy (574). Report volume has a seasonal shape, with more reports in the warmer months when parasite products are in heavier use.

The months around it

Drugs named most often, by active ingredient

Active ingredients recorded for the drug	Reports	Share of the month's reports
Milbemycin Oxime + Spinosad	1,469	29.2%
Ivermectin + Pyrantel Pamoate	643	12.8%
Spinosad	508	10.1%
Oclacitinib	272	5.4%
Selamectin	207	4.1%
Lufenuron + Milbemycin Oxime	183	3.6%
Carprofen	147	2.9%
Moxidectin	146	2.9%
Ivermectin + Praziquantel + Pyrantel Pamoate	126	2.5%
Imidacloprid + Moxidectin	113	2.2%
Cyclosporine	111	2.2%
Afoxolaner	104	2.1%
Ivermectin	96	1.9%
Insulin	87	1.7%
Trilostane	78	1.6%

Ordered by report count, which follows how widely each drug was in use. FDA states that these data cannot be used to estimate risk or to compare one product with another. Brand and manufacturer names are masked by FDA in these records.

Signs listed most often

Emesis[vomiting]22.1%1,114
Lack of efficacy - NOS[the product did not have the expected effect]16.3%822
Lethargy[unusually tired or inactive]11.4%574
Vomiting9.2%462
Ineffective, heartworm larvae[legacy FDA term: the product did not have the expected effect (heartworm larvae)]6.8%340
Uncoded sign[a sign with no matching dictionary term]6.4%320
Diarrhoea[diarrhea]5.1%257
Digestive tract disorder NOS[digestive problem, type not specified]4.9%245
Lack of efficacy (endoparasite) - hookworm[the product did not have the expected effect: hookworms]4.3%214
Ineffective, ascarids NOS[legacy FDA term: the product did not have the expected effect (ascarids nos)]4.2%212
Other abnormal test result NOS[abnormal laboratory result, type not specified]4.1%204
Anorexia[not eating]3.9%194
Unpalatable[legacy FDA term: the animal would not take it]3.5%178
Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]3.3%165
Seizure NOS[seizure, type not specified]3.2%159

Single ingredients, pooled

Spinosad39.1%1,970

Milbemycin Oxime33%1,661

Ivermectin17.3%872

Pyrantel Pamoate16.2%817

Oclacitinib5.4%272

Moxidectin5.2%261

Praziquantel4.9%247

Selamectin4.1%207

Lufenuron4%200

Carprofen2.9%148

Imidacloprid2.6%129

Cyclosporine2.2%111

Species

Dog76.1%3,830

Cat9%452

Horse0.7%33

Other or not given14.2%717

Questions about March 2014

How many animal drug adverse event reports did FDA receive in March 2014?

5,032 reports are in the openFDA release of 28 Sep 2026. The same month a year earlier has 5,164.

Which drugs were named most often?

By active ingredient: milbemycin oxime + spinosad (1,469), ivermectin + pyrantel pamoate (643), spinosad (508), oclacitinib (272) and selamectin (207). Brands are masked in the public data.

Which signs were listed most often?

emesis (1,114), lack of efficacy - NOS (822), lethargy (574), vomiting (462) and ineffective, heartworm larvae (340).

Can the count for a month still change?

Yes. FDA posts reports quarterly with a delay of three to six months, so the newest months are incomplete and usually grow in later releases. Older months change little.

Does a busy month mean something went wrong that month?

Not by itself. The date is when FDA received the report, not when the event happened, and volume follows season, product launches and publicity. FDA states that "there is no certainty that the reported drug or device caused the adverse event" and that the event "may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources."

Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 30 Sep 2026. The month is the date FDA first received the report, not the date of the event. No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.