April 2018: adverse event reports that FDA received

Month in which FDA received the reports

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

FDA received 6,033 adverse event reports for animal drugs in April 2018. It received 6,712 reports in April 2017. The average of the 12 months before April 2018 is 6,261 reports for each month.

Of the 6,033 reports, 74.9% are about dogs, 9% are about cats and 1% are about horses. The other reports are about other species, or give no species. A report is not proof that a drug caused a sign.

Search engines do not list month pages. The site keeps the page, and the list of months links it.

The months before and after

Reports for each month, Oct 2016 to Oct 2018. The column with the outline is April 2018.

Reports by species

Dog74.9%4,516
Cat9%543
Horse1%58
Other species, or species not given15.2%916

Drug pages with reports received in April 2018

The table has every drug page with 10 or more reports that FDA received in April 2018, in order of name. No count decides which drug is in the table. The table has 76 drug pages.

Show the 76 drug pages

Drug pages with 10 or more reports received in April 2018, in order of name
Active ingredients	Reports received in April 2018
(S) - methoprene	15
Acepromazine Maleate	13
Afoxolaner	377
Amoxicillin Trihydrate + Clavulanate Potassium	41
Atipamezole Hydrochloride	13
Buprenorphine	36
Butorphanol Tartrate	25
Capromorelin	47
Carprofen	111
Cefovecin sodium	73
Cefpodoxime proxetil	16
Ceftiofur Crystalline Free Acid	13
Cephalexin	24
Cyclosporine	40
Deracoxib	28
Desoxycorticosterone Pivalate	16
Dexamethasone	19
Dexmedetomidine hydrochloride	15
Diazepam	13
Diphenhydramine	37
Doramectin	11
Doxycycline	32
Emodepside + Praziquantel	51
Enalapril Maleate	15
Enrofloxacin	38
Estriol	15
Famotidine	19
Febantel + Praziquantel + Pyrantel Pamoate	49
Fenbendazole	15
Firocoxib	21
Florfenicol + Mometasone furoate + Terbinafine	38
Florfenicol + Terbinafine	25
Fluralaner	867
Furosemide	15
Gabapentin	32
Grapiprant	116
Imidacloprid	30
Imidacloprid + Moxidectin	146
Insulin	72
Isoflurane	15
Ivermectin	68
Ivermectin + Praziquantel + Pyrantel Pamoate	20
Ivermectin + Pyrantel Pamoate	1,017
Ketamine Hydrochloride	27
Levothyroxine sodium	14
Lotilaner	27
Lufenuron + Milbemycin Oxime	152
Lufenuron + Milbemycin Oxime + Praziquantel	97
Maropitant	85
Melarsomine Dihydrochloride	90
Meloxicam	50
Metronidazole	23
Milbemycin Oxime	72
Milbemycin Oxime + Praziquantel	329
Milbemycin Oxime + Spinosad	712
Monensin	22
Moxidectin	212
Nitenpyram	62
Oclacitinib	238
Omeprazole	18
Pimobendan	30
Polysulfated Glycosaminoglycan	47
Praziquantel	21
Praziquantel + Pyrantel Pamoate	18
Prednisolone	17
Prednisone	55
Propofol	18
Pyrantel Pamoate	17
Robenacoxib	25
Sarolaner	216
Selamectin	166
Sodium Chloride	26
Spinosad	138
Tramadol	45
Trilostane	87
Tulathromycin	10

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
Commonly used products may have a higher number of reported adverse events due to the higher total number of animals being given the product.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Signs that the reports of the month list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 6,033 reports of the month.

The sign that is in the largest number of the reports comes first.

Vomiting19%1,147 reports
Lethargy[unusually tired or inactive]9.5%576 reports
Ineffective, hooks[legacy FDA term: the product did not have the expected effect (hooks)]7.6%461 reports
Diarrhoea[diarrhea]5.8%351 reports
Lack of efficacy (endoparasite) - heartworm[the product did not have the expected effect: heartworm]4.5%271 reports
Unpalatable[legacy FDA term: the animal would not take it]3.7%225 reports
Ineffective, heartworm larvae[legacy FDA term: the product did not have the expected effect (heartworm larvae)]3.7%223 reports
Anorexia[not eating]3.1%190 reports
Emesis (multiple)[vomiting more than once]2.9%175 reports
Seizure NOS[seizure, type not specified]2.6%155 reports
Death2.3%141 reports
Death by euthanasia[the animal was euthanized]2.3%140 reports
Lack of efficacy - NOS[the product did not have the expected effect]2.3%140 reports
Ataxia[unsteady, uncoordinated movement]2.2%130 reports

Show the next 1 signs

Other abnormal test result NOS[abnormal laboratory result, type not specified]2.1%126 reports

Ingredients, all combinations

The list has every active ingredient with 10 or more reports received in April 2018, in order of name. It has 75 ingredients.

Show the 75 ingredients

The same month in other years

Cite this page

Pet Drug Reports. April 2018: adverse event reports for animal drugs. https://petdrugreports.com/month/2018-04/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The month is the month in which FDA received the report, not the month of the event.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this month

Can the count for April 2018 change?: Yes. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
Does the month show when the event occurred?: No. The month is the month in which FDA received the report. The event can be from an earlier month.
Which sign is in the largest number of the reports of the month?: "Vomiting" is in 1,147 reports of the 6,033 reports of April 2018 (19%).