April 2022: adverse event reports that FDA received

Month in which FDA received the reports

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

FDA received 4,953 adverse event reports for animal drugs in April 2022. It received 6,097 reports in April 2021. The average of the 12 months before April 2022 is 5,123 reports for each month.

Of the 4,953 reports, 76.5% are about dogs, 7.8% are about cats and 1.5% are about horses. The other reports are about other species, or give no species. A report is not proof that a drug caused a sign.

Search engines do not list month pages. The site keeps the page, and the list of months links it.

The months before and after

Reports for each month, Oct 2020 to Oct 2022. The column with the outline is April 2022.

Reports by species

Dog76.5%3,789
Cat7.8%385
Horse1.5%74
Other species, or species not given14.2%705

Drug pages with reports received in April 2022

The table has every drug page with 10 or more reports that FDA received in April 2022, in order of name. No count decides which drug is in the table. The table has 75 drug pages.

Show the 75 drug pages

Drug pages with 10 or more reports received in April 2022, in order of name
Active ingredients	Reports received in April 2022
Acepromazine Maleate	11
Afoxolaner	356
Amoxicillin Trihydrate + Clavulanate Potassium	22
Atipamezole Hydrochloride	10
Betamethasone Acetate + Florfenicol + Terbinafine	11
Buprenorphine	21
Butorphanol Tartrate	39
Capromorelin	28
Carprofen	70
Cefovecin sodium	39
Cefpodoxime proxetil	15
Cyclosporine	44
Dexamethasone	14
Dexmedetomidine	21
Dexmedetomidine hydrochloride	19
Diphenhydramine	18
Doxycycline	22
Emodepside + Praziquantel	12
Enalapril Maleate	11
Enrofloxacin	16
Eprinomectin	16
Eprinomectin + Praziquantel	14
Estriol	14
Febantel + Praziquantel + Pyrantel Pamoate	18
Firocoxib	25
Florfenicol + Mometasone furoate + Terbinafine	34
Fluralaner	511
Fluralaner + Moxidectin	44
Furosemide	10
Gabapentin	54
Gentamicin Sulfate + Hydrocortisone aceponate + Miconazole Nitrate	17
Grapiprant	56
Imidacloprid	40
Imidacloprid + Moxidectin	64
Insulin	64
Isoflurane	28
Ivermectin	33
Ivermectin + Praziquantel + Pyrantel Pamoate	11
Ivermectin + Pyrantel Pamoate	662
Ketamine Hydrochloride	14
Levothyroxine sodium	13
Lotilaner	81
Lufenuron + Milbemycin Oxime	73
Lufenuron + Milbemycin Oxime + Praziquantel	57
Maropitant	71
Melarsomine Dihydrochloride	87
Meloxicam	33
Midazolam	13
Milbemycin Oxime	29
Milbemycin Oxime + Praziquantel	262
Milbemycin Oxime + Spinosad	163
Mirtazapine	13
Moxidectin	400
Moxidectin + Pyrantel Pamoate + Sarolaner	10
Nitenpyram	44
Oclacitinib	104
Omeprazole	20
Pergolide mesylate	11
Pimobendan	50
Polysulfated Glycosaminoglycan	40
Praziquantel + Pyrantel Pamoate	17
Prednisolone	12
Prednisone	39
Progesterone	10
Propofol	29
Pyrantel Pamoate	14
Pyrantel Pamoate + Sarolaner	744
Robenacoxib	10
Sarolaner	92
Sarolaner + Selamectin	114
Selamectin	71
Sodium Chloride	58
Spinosad	20
Tigilanol tiglate	37
Trilostane	77

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
Commonly used products may have a higher number of reported adverse events due to the higher total number of animals being given the product.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Signs that the reports of the month list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 4,953 reports of the month.

The sign that is in the largest number of the reports comes first.

Vomiting16.2%801 reports
Lack of efficacy (endoparasite) - heartworm[the product did not have the expected effect: heartworm]11.2%556 reports
Lack of efficacy (endoparasite) - hookworm[the product did not have the expected effect: hookworms]7.9%391 reports
Lethargy[unusually tired or inactive]7.1%351 reports
Lack of efficacy (ectoparasite) - tick NOS[the product did not have the expected effect: ticks]6.7%330 reports
Diarrhoea[diarrhea]5.5%274 reports
Lack of efficacy (bacteria) - Borrelia[the product did not have the expected effect: Borrelia (Lyme disease bacteria)]4.2%210 reports
Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]4.2%209 reports
Seizure NOS[seizure, type not specified]3.6%178 reports
Lack of efficacy (endoparasite) - roundworm NOS[the product did not have the expected effect: roundworms]3.2%157 reports
Death2.6%128 reports
Containers, Damaged[a product quality report, not a sign in an animal]2.4%118 reports
Lack of efficacy - NOS[the product did not have the expected effect]2.4%118 reports
Anorexia[not eating]2%101 reports

Show the next 1 signs

Not eating2%99 reports

Ingredients, all combinations

The list has every active ingredient with 10 or more reports received in April 2022, in order of name. It has 73 ingredients.

Show the 73 ingredients

The same month in other years

Cite this page

Pet Drug Reports. April 2022: adverse event reports for animal drugs. https://petdrugreports.com/month/2022-04/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The month is the month in which FDA received the report, not the month of the event.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this month

Can the count for April 2022 change?: Yes. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
Does the month show when the event occurred?: No. The month is the month in which FDA received the report. The event can be from an earlier month.
Which sign is in the largest number of the reports of the month?: "Vomiting" is in 801 reports of the 4,953 reports of April 2022 (16.2%).