April 1996: adverse event reports received

313 reports in the openFDA release of 28 Sep 2026

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An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources. FDA Center for Veterinary Medicine

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313reports received

161same month a year earlier+94%

210monthly average, preceding 12 months

42.5%concern dogscats 18.5%

FDA's database holds 313 adverse event reports received in April 1996, against 161 in the same month a year earlier and a monthly average of 210 over the preceding 12 months.

42.5% of the month's reports concern dogs, 18.5% cats and 8% horses; the rest concern other species, exposed people, or give no species.

By active ingredient, the drugs named most often were lufenuron (60), melengestrol acetate (32) and amoxicillin (27), and the terms listed most often were vomiting (45), death (44) and ineffective, estrus suppressio (32). Report volume has a seasonal shape, with more reports in the warmer months when parasite products are in heavier use.

The months around it

Drugs named most often, by active ingredient

Active ingredients recorded for the drug	Reports	Share of the month's reports
Lufenuron	60	19.2%
Melengestrol Acetate	32	10.2%
Amoxicillin	27	8.6%
Epsiprantel	22	7%
Ketamine Hydrochloride	18	5.8%
Pyrantel Tartrate	15	4.8%
Milbemycin Oxime	11	3.5%
Tiletamine Hydrochloride + Zolazepam Hydrochloride	11	3.5%
Tilmicosin Phosphate	9	2.9%
Oxytetracycline	7	2.2%
Ivermectin	6	1.9%
Ormetoprim + Sulfadimethoxine	6	1.9%
Oxibendazole	6	1.9%
Dichlorophene + Toluene	5	1.6%
Ivermectin + Pyrantel Pamoate	5	1.6%

Ordered by report count, which follows how widely each drug was in use. FDA states that these data cannot be used to estimate risk or to compare one product with another. Brand and manufacturer names are masked by FDA in these records.

Signs listed most often

Vomiting14.4%45
Death14.1%44
Ineffective, estrus suppressio[legacy FDA term: the product did not have the expected effect (estrus suppressio)]10.2%32
Depression[dull, quiet or withdrawn]7.7%24
Convulsion[seizure]5.8%18
Diarrhoea[diarrhea]5.4%17
Anorexia[not eating]5.1%16
Lack of efficacy (endoparasite) - tapeworm[the product did not have the expected effect: tapeworms]4.8%15
Unclassifiable adverse event[event that fits no dictionary term]4.5%14
Ataxia[unsteady, uncoordinated movement]3.8%12
Ineffective, anesthesia[legacy FDA term: the product did not have the expected effect (anesthesia)]3.5%11
Pruritus[itching]3.2%10
Accidental exposure[exposure that was not intended]2.9%9
Alopecia NOS[hair loss, type not specified]2.6%8
Fever2.6%8

Single ingredients, pooled

Lufenuron19.2%60

Melengestrol Acetate10.2%32

Amoxicillin8.6%27

Epsiprantel7%22

Ketamine Hydrochloride5.8%18

Pyrantel Tartrate4.8%15

Ivermectin3.8%12

Milbemycin Oxime3.5%11

Tiletamine Hydrochloride3.5%11

Zolazepam Hydrochloride3.5%11

Tilmicosin Phosphate2.9%9

Pyrantel Pamoate2.6%8

Species

Dog42.5%133

Cat18.5%58

Horse8%25

Other or not given31%97

Questions about April 1996

How many animal drug adverse event reports did FDA receive in April 1996?

313 reports are in the openFDA release of 28 Sep 2026. The same month a year earlier has 161.

Which drugs were named most often?

By active ingredient: lufenuron (60), melengestrol acetate (32), amoxicillin (27), epsiprantel (22) and ketamine hydrochloride (18). Brands are masked in the public data.

Which signs were listed most often?

vomiting (45), death (44), ineffective, estrus suppressio (32), depression (24) and convulsion (18).

Can the count for a month still change?

Yes. FDA posts reports quarterly with a delay of three to six months, so the newest months are incomplete and usually grow in later releases. Older months change little.

Does a busy month mean something went wrong that month?

Not by itself. The date is when FDA received the report, not when the event happened, and volume follows season, product launches and publicity. FDA states that "there is no certainty that the reported drug or device caused the adverse event" and that the event "may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources."

Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 1 Oct 2026. The month is the date FDA first received the report, not the date of the event. No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.