July 2011: adverse event reports received

4,558 reports in the openFDA release of 28 Sep 2026

Read this first · FDA's caveat, in its words

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources. FDA Center for Veterinary Medicine

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Not veterinary advice. This site lists what was reported to FDA. For an animal that is unwell, contact a veterinarian.

4,558reports received

4,168same month a year earlier+9%

3,739monthly average, preceding 12 months

79.5%concern dogscats 8.2%

FDA's database holds 4,558 adverse event reports received in July 2011, against 4,168 in the same month a year earlier and a monthly average of 3,739 over the preceding 12 months.

79.5% of the month's reports concern dogs, 8.2% cats and 0.9% horses; the rest concern other species, exposed people, or give no species.

By active ingredient, the drugs named most often were spinosad (973), milbemycin oxime + spinosad (939) and ivermectin + pyrantel pamoate (570), and the terms listed most often were vomiting (1,505), depression (529) and ineffective, heartworm larvae (488). Report volume has a seasonal shape, with more reports in the warmer months when parasite products are in heavier use.

The months around it

Drugs named most often, by active ingredient

Active ingredients recorded for the drug	Reports	Share of the month's reports
Spinosad	973	21.3%
Milbemycin Oxime + Spinosad	939	20.6%
Ivermectin + Pyrantel Pamoate	570	12.5%
Milbemycin Oxime	232	5.1%
Selamectin	225	4.9%
Imidacloprid + Moxidectin	155	3.4%
Lufenuron + Milbemycin Oxime	97	2.1%
Carprofen	89	2%
Melarsomine Dihydrochloride	88	1.9%
Cyclosporine	83	1.8%
Meloxicam	72	1.6%
Moxidectin	62	1.4%
Ivermectin + Praziquantel + Pyrantel Pamoate	47	1%
Cefovecin sodium	44	1%
Firocoxib	44	1%

Ordered by report count, which follows how widely each drug was in use. FDA states that these data cannot be used to estimate risk or to compare one product with another. Brand and manufacturer names are masked by FDA in these records.

Signs listed most often

Vomiting33%1,505
Depression[dull, quiet or withdrawn]11.6%529
Ineffective, heartworm larvae[legacy FDA term: the product did not have the expected effect (heartworm larvae)]10.7%488
Anorexia[not eating]8.4%385
Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]7.5%342
Diarrhoea[diarrhea]5.7%261
Accidental exposure[exposure that was not intended]3.6%165
Lack of efficacy (endoparasite) - hookworm[the product did not have the expected effect: hookworms]3.6%165
Ataxia[unsteady, uncoordinated movement]3.4%157
Death3.4%157
Pruritus[itching]3.2%146
Convulsion[seizure]2.6%117
Unpalatable[legacy FDA term: the animal would not take it]2.1%94
Trembling2%92
Hypersalivation[drooling]1.8%84

Single ingredients, pooled

Spinosad41.9%1,912

Milbemycin Oxime27.8%1,265

Pyrantel Pamoate14.7%671

Ivermectin14.6%665

Selamectin4.9%225

Moxidectin4.8%217

Imidacloprid3.4%155

Praziquantel2.8%128

Lufenuron2.4%111

Carprofen2%89

Melarsomine Dihydrochloride1.9%88

Cyclosporine1.8%83

Species

Dog79.5%3,624

Cat8.2%372

Horse0.9%40

Other or not given11.5%522

Questions about July 2011

How many animal drug adverse event reports did FDA receive in July 2011?

4,558 reports are in the openFDA release of 28 Sep 2026. The same month a year earlier has 4,168.

Which drugs were named most often?

By active ingredient: spinosad (973), milbemycin oxime + spinosad (939), ivermectin + pyrantel pamoate (570), milbemycin oxime (232) and selamectin (225). Brands are masked in the public data.

Which signs were listed most often?

vomiting (1,505), depression (529), ineffective, heartworm larvae (488), anorexia (385) and lack of efficacy (ectoparasite) - flea (342).

Can the count for a month still change?

Yes. FDA posts reports quarterly with a delay of three to six months, so the newest months are incomplete and usually grow in later releases. Older months change little.

Does a busy month mean something went wrong that month?

Not by itself. The date is when FDA received the report, not when the event happened, and volume follows season, product launches and publicity. FDA states that "there is no certainty that the reported drug or device caused the adverse event" and that the event "may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources."

Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 1 Oct 2026. The month is the date FDA first received the report, not the date of the event. No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.