October 2008: adverse event reports received

3,113 reports in the openFDA release of 28 Sep 2026

Read this first · FDA's caveat, in its words

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources. FDA Center for Veterinary Medicine

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Not veterinary advice. This site lists what was reported to FDA. For an animal that is unwell, contact a veterinarian.

3,113reports received

2,613same month a year earlier+19%

2,760monthly average, preceding 12 months

73%concern dogscats 11.3%

FDA's database holds 3,113 adverse event reports received in October 2008, against 2,613 in the same month a year earlier and a monthly average of 2,760 over the preceding 12 months.

73% of the month's reports concern dogs, 11.3% cats and 1.6% horses; the rest concern other species, exposed people, or give no species.

By active ingredient, the drugs named most often were ivermectin + pyrantel pamoate (521), spinosad (435) and selamectin (258), and the terms listed most often were vomiting (611), ineffective, heartworm larvae (483) and anorexia (269). Report volume has a seasonal shape, with more reports in the warmer months when parasite products are in heavier use.

The months around it

Drugs named most often, by active ingredient

Active ingredients recorded for the drug	Reports	Share of the month's reports
Ivermectin + Pyrantel Pamoate	521	16.7%
Spinosad	435	14%
Selamectin	258	8.3%
Milbemycin Oxime	233	7.5%
Carprofen	156	5%
Cyclosporine	122	3.9%
Lufenuron + Milbemycin Oxime	92	3%
Meloxicam	88	2.8%
Melarsomine Dihydrochloride	77	2.5%
Imidacloprid + Moxidectin	69	2.2%
Cefovecin sodium	68	2.2%
Firocoxib	63	2%
Nitenpyram	52	1.7%
Ivermectin	50	1.6%
Deracoxib	46	1.5%

Ordered by report count, which follows how widely each drug was in use. FDA states that these data cannot be used to estimate risk or to compare one product with another. Brand and manufacturer names are masked by FDA in these records.

Signs listed most often

Vomiting19.6%611
Ineffective, heartworm larvae[legacy FDA term: the product did not have the expected effect (heartworm larvae)]15.5%483
Anorexia[not eating]8.6%269
Depression[dull, quiet or withdrawn]8.4%260
Diarrhoea[diarrhea]6.4%199
Lack of efficacy (endoparasite) - hookworm[the product did not have the expected effect: hookworms]5.5%171
Death4.8%149
Ineffective, ascarids NOS[legacy FDA term: the product did not have the expected effect (ascarids nos)]3.2%101
Accidental exposure[exposure that was not intended]3.1%98
Pruritus[itching]3%93
Convulsion[seizure]2.9%89
Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]2.7%85
Elevated alanine aminotransferase (ALT)[a liver enzyme above the normal range]2.5%79
Ataxia[unsteady, uncoordinated movement]2.3%73
Hypersalivation[drooling]2.1%65

Single ingredients, pooled

Ivermectin20.6%641

Pyrantel Pamoate18.4%572

Spinosad14%435

Milbemycin Oxime10.4%325

Selamectin8.3%258

Carprofen5%156

Cyclosporine3.9%122

Lufenuron3.2%99

Meloxicam2.8%88

Moxidectin2.8%86

Praziquantel2.7%83

Melarsomine Dihydrochloride2.5%77

Species

Dog73%2,271

Cat11.3%352

Horse1.6%50

Other or not given14.1%440

Questions about October 2008

How many animal drug adverse event reports did FDA receive in October 2008?

3,113 reports are in the openFDA release of 28 Sep 2026. The same month a year earlier has 2,613.

Which drugs were named most often?

By active ingredient: ivermectin + pyrantel pamoate (521), spinosad (435), selamectin (258), milbemycin oxime (233) and carprofen (156). Brands are masked in the public data.

Which signs were listed most often?

vomiting (611), ineffective, heartworm larvae (483), anorexia (269), depression (260) and diarrhoea (199).

Can the count for a month still change?

Yes. FDA posts reports quarterly with a delay of three to six months, so the newest months are incomplete and usually grow in later releases. Older months change little.

Does a busy month mean something went wrong that month?

Not by itself. The date is when FDA received the report, not when the event happened, and volume follows season, product launches and publicity. FDA states that "there is no certainty that the reported drug or device caused the adverse event" and that the event "may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources."

Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 1 Oct 2026. The month is the date FDA first received the report, not the date of the event. No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.