May 2000: adverse event reports received

1,784 reports in the openFDA release of 28 Sep 2026

Read this first · FDA's caveat, in its words

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources. FDA Center for Veterinary Medicine

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Not veterinary advice. This site lists what was reported to FDA. For an animal that is unwell, contact a veterinarian.

1,784reports received

585same month a year earlier+205%

1,114monthly average, preceding 12 months

67.3%concern dogscats 11.4%

FDA's database holds 1,784 adverse event reports received in May 2000, against 585 in the same month a year earlier and a monthly average of 1,114 over the preceding 12 months.

67.3% of the month's reports concern dogs, 11.4% cats and 3.5% horses; the rest concern other species, exposed people, or give no species.

By active ingredient, the drugs named most often were selamectin (658), carprofen (347) and medetomidine (82), and the terms listed most often were accidental exposure (260), vomiting (218) and depression (205). Report volume has a seasonal shape, with more reports in the warmer months when parasite products are in heavier use.

The months around it

Drugs named most often, by active ingredient

Active ingredients recorded for the drug	Reports	Share of the month's reports
Selamectin	658	36.9%
Carprofen	347	19.5%
Medetomidine	82	4.6%
Etodolac	69	3.9%
Selegiline Hydrochloride	65	3.6%
Lufenuron + Milbemycin Oxime	55	3.1%
Milbemycin Oxime	54	3%
Moxidectin	54	3%
Melarsomine Dihydrochloride	44	2.5%
Tiletamine Hydrochloride + Zolazepam Hydrochloride	32	1.8%
Amoxicillin	28	1.6%
Orbifloxacin	17	1%
Tilmicosin Phosphate	17	1%
Oxibendazole	16	0.9%
Pentobarbital	15	0.8%

Ordered by report count, which follows how widely each drug was in use. FDA states that these data cannot be used to estimate risk or to compare one product with another. Brand and manufacturer names are masked by FDA in these records.

Signs listed most often

Accidental exposure[exposure that was not intended]14.6%260
Vomiting12.2%218
Depression[dull, quiet or withdrawn]11.5%205
Anorexia[not eating]9.2%164
No sign[no clinical sign was reported]9%160
Diarrhoea[diarrhea]6.3%113
Death5.8%103
Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]5.6%100
Unclassifiable adverse event[event that fits no dictionary term]5.5%99
Elevated serum alkaline phosphatase (SAP)[a liver and bone enzyme above the normal range]5.3%95
Elevated alanine aminotransferase (ALT)[a liver enzyme above the normal range]4.8%85
Convulsion[seizure]3.9%70
Ineffective, heartworm larvae[legacy FDA term: the product did not have the expected effect (heartworm larvae)]3.8%68
Ataxia[unsteady, uncoordinated movement]3.8%67
Pruritus[itching]3.4%61

Single ingredients, pooled

Selamectin36.9%658

Carprofen19.5%347

Milbemycin Oxime6.1%109

Medetomidine4.6%82

Etodolac3.9%69

Selegiline Hydrochloride3.6%65

Lufenuron3.4%60

Moxidectin3%54

Melarsomine Dihydrochloride2.5%44

Tiletamine Hydrochloride1.8%32

Zolazepam Hydrochloride1.8%32

Amoxicillin1.6%28

Species

Dog67.3%1,200

Cat11.4%204

Horse3.5%63

Other or not given17.8%317

Questions about May 2000

How many animal drug adverse event reports did FDA receive in May 2000?

1,784 reports are in the openFDA release of 28 Sep 2026. The same month a year earlier has 585.

Which drugs were named most often?

By active ingredient: selamectin (658), carprofen (347), medetomidine (82), etodolac (69) and selegiline hydrochloride (65). Brands are masked in the public data.

Which signs were listed most often?

accidental exposure (260), vomiting (218), depression (205), anorexia (164) and no sign (160).

Can the count for a month still change?

Yes. FDA posts reports quarterly with a delay of three to six months, so the newest months are incomplete and usually grow in later releases. Older months change little.

Does a busy month mean something went wrong that month?

Not by itself. The date is when FDA received the report, not when the event happened, and volume follows season, product launches and publicity. FDA states that "there is no certainty that the reported drug or device caused the adverse event" and that the event "may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources."

Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 1 Oct 2026. The month is the date FDA first received the report, not the date of the event. No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.