February 2021: adverse event reports that FDA received

Month in which FDA received the reports

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

FDA received 4,232 adverse event reports for animal drugs in February 2021. It received 4,729 reports in February 2020. The average of the 12 months before February 2021 is 5,636 reports for each month.

Of the 4,232 reports, 74.3% are about dogs, 8.8% are about cats and 1% are about horses. The other reports are about other species, or give no species. A report is not proof that a drug caused a sign.

Search engines do not list month pages. The site keeps the page, and the list of months links it.

The months before and after

Reports for each month, Aug 2019 to Aug 2021. The column with the outline is February 2021.

Reports by species

Dog74.3%3,143
Cat8.8%373
Horse1%43
Other species, or species not given15.9%673

Drug pages with reports received in February 2021

The table has every drug page with 10 or more reports that FDA received in February 2021, in order of name. No count decides which drug is in the table. The table has 79 drug pages.

Show the 79 drug pages

Drug pages with 10 or more reports received in February 2021, in order of name
Active ingredients	Reports received in February 2021
Acepromazine Maleate	13
Afoxolaner	243
Alfaxalone	10
Amoxicillin Trihydrate + Clavulanate Potassium	18
Betamethasone Acetate + Florfenicol + Terbinafine	11
Buprenorphine	14
Butorphanol Tartrate	46
Capromorelin	17
Carprofen	94
Cefovecin sodium	46
Cefpodoxime proxetil	10
Clotrimazole + Gentamicin	20
Cyclosporine	29
Deracoxib	10
Desoxycorticosterone Pivalate	12
Dexamethasone	18
Dexamethasone + Neomycin Sulfate + Thiabendazole	13
Dexmedetomidine	31
Dexmedetomidine hydrochloride	19
Diphenhydramine	22
Doramectin	14
Doxycycline	30
Emodepside + Praziquantel	24
Enrofloxacin	21
Eprinomectin	12
Estriol	12
Famotidine	10
Febantel + Praziquantel + Pyrantel Pamoate	52
Fenbendazole	13
Florfenicol + Mometasone furoate + Terbinafine	35
Fluralaner	288
Fluralaner + Moxidectin	29
Gabapentin	40
Grapiprant	49
Hydromorphone	24
Imidacloprid	34
Imidacloprid + Moxidectin	80
Insulin	70
Isoflurane	32
Ivermectin	50
Ivermectin + Praziquantel + Pyrantel Pamoate	21
Ivermectin + Pyrantel Pamoate	600
Ketamine Hydrochloride	22
Levothyroxine sodium	14
Lotilaner	71
Lufenuron + Milbemycin Oxime	81
Lufenuron + Milbemycin Oxime + Praziquantel	51
Maropitant	60
Melarsomine Dihydrochloride	89
Meloxicam	42
Metronidazole	15
Midazolam	10
Milbemycin Oxime	40
Milbemycin Oxime + Praziquantel	300
Milbemycin Oxime + Spinosad	274
Monensin	20
Moxidectin	391
Moxidectin + Pyrantel Pamoate + Sarolaner	10
Nitenpyram	41
Oclacitinib	104
Omeprazole	18
Phenylpropanolamine hydrochloride	11
Pimobendan	20
Polysulfated Glycosaminoglycan	25
Praziquantel	11
Praziquantel + Pyrantel Pamoate	23
Prednisolone	11
Prednisone	49
Propofol	27
Pyrantel Pamoate	20
Pyrantel Pamoate + Sarolaner	309
Robenacoxib	18
Sarolaner	93
Sarolaner + Selamectin	75
Selamectin	71
Sodium Chloride	64
Spinosad	36
Trazodone	11
Trilostane	79

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
Commonly used products may have a higher number of reported adverse events due to the higher total number of animals being given the product.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Signs that the reports of the month list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 4,232 reports of the month.

The sign that is in the largest number of the reports comes first.

Vomiting15.7%664 reports
Lack of efficacy (endoparasite) - heartworm[the product did not have the expected effect: heartworm]14.7%620 reports
Lethargy[unusually tired or inactive]8.3%351 reports
Diarrhoea[diarrhea]5.9%249 reports
Lack of efficacy (endoparasite) - roundworm NOS[the product did not have the expected effect: roundworms]4%169 reports
Seizure NOS[seizure, type not specified]3.5%148 reports
Lack of efficacy - NOS[the product did not have the expected effect]3.4%145 reports
Lack of efficacy (endoparasite) - hookworm[the product did not have the expected effect: hookworms]3.3%141 reports
Death2.6%110 reports
Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]2.5%106 reports
Not eating2.4%103 reports
Containers, Damaged[a product quality report, not a sign in an animal]2.4%101 reports
Unpalatable[legacy FDA term: the animal would not take it]2.3%98 reports
Anorexia[not eating]2.2%93 reports

Show the next 1 signs

Behavioural disorder NOS[behaviour change, type not specified]2.2%93 reports

Ingredients, all combinations

The list has every active ingredient with 10 or more reports received in February 2021, in order of name. It has 76 ingredients.

Show the 76 ingredients

The same month in other years

Cite this page

Pet Drug Reports. February 2021: adverse event reports for animal drugs. https://petdrugreports.com/month/2021-02/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The month is the month in which FDA received the report, not the month of the event.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this month

Can the count for February 2021 change?: Yes. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
Does the month show when the event occurred?: No. The month is the month in which FDA received the report. The event can be from an earlier month.
Which sign is in the largest number of the reports of the month?: "Vomiting" is in 664 reports of the 4,232 reports of February 2021 (15.7%).