January 2000: adverse event reports received

911 reports in the openFDA release of 28 Sep 2026

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An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources. FDA Center for Veterinary Medicine

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911reports received

422same month a year earlier+116%

957monthly average, preceding 12 months

64.8%concern dogscats 16.1%

FDA's database holds 911 adverse event reports received in January 2000, against 422 in the same month a year earlier and a monthly average of 957 over the preceding 12 months.

64.8% of the month's reports concern dogs, 16.1% cats and 1.8% horses; the rest concern other species, exposed people, or give no species.

By active ingredient, the drugs named most often were carprofen (344), selamectin (163) and etodolac (43), and the terms listed most often were accidental exposure (173), no sign (126) and vomiting (113). Report volume has a seasonal shape, with more reports in the warmer months when parasite products are in heavier use.

The months around it

Drugs named most often, by active ingredient

Active ingredients recorded for the drug	Reports	Share of the month's reports
Carprofen	344	37.8%
Selamectin	163	17.9%
Etodolac	43	4.7%
Selegiline Hydrochloride	27	3%
Amoxicillin	25	2.7%
Milbemycin Oxime	24	2.6%
Moxidectin	19	2.1%
Lufenuron + Milbemycin Oxime	18	2%
Tilmicosin Phosphate	15	1.6%
Medetomidine	14	1.5%
Atipamezole Hydrochloride	11	1.2%
Diethylcarbamazine Citrate	11	1.2%
Doramectin	10	1.1%
Ivermectin	10	1.1%
Ketamine Hydrochloride	10	1.1%

Ordered by report count, which follows how widely each drug was in use. FDA states that these data cannot be used to estimate risk or to compare one product with another. Brand and manufacturer names are masked by FDA in these records.

Signs listed most often

Accidental exposure[exposure that was not intended]19%173
No sign[no clinical sign was reported]13.8%126
Vomiting12.4%113
Depression[dull, quiet or withdrawn]11.1%101
Death9.4%86
Anorexia[not eating]9.1%83
Elevated alanine aminotransferase (ALT)[a liver enzyme above the normal range]7.4%67
Elevated serum alkaline phosphatase (SAP)[a liver and bone enzyme above the normal range]6.3%57
Diarrhoea[diarrhea]6.1%56
Elevated total bilirubin[bilirubin above the normal range]4.2%38
Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]4.2%38
Convulsion[seizure]3.8%35
Ataxia[unsteady, uncoordinated movement]3.7%34
Icterus[jaundice (yellowing)]3.6%33
Unclassifiable adverse event[event that fits no dictionary term]3.6%33

Single ingredients, pooled

Carprofen37.8%344

Selamectin17.9%163

Etodolac4.7%43

Milbemycin Oxime4.6%42

Selegiline Hydrochloride3%27

Amoxicillin2.7%25

Lufenuron2.4%22

Moxidectin2.1%19

Ivermectin1.9%17

Tilmicosin Phosphate1.6%15

Medetomidine1.5%14

Atipamezole Hydrochloride1.2%11

Species

Dog64.8%590

Cat16.1%147

Horse1.8%16

Other or not given17.3%158

Questions about January 2000

How many animal drug adverse event reports did FDA receive in January 2000?

911 reports are in the openFDA release of 28 Sep 2026. The same month a year earlier has 422.

Which drugs were named most often?

By active ingredient: carprofen (344), selamectin (163), etodolac (43), selegiline hydrochloride (27) and amoxicillin (25). Brands are masked in the public data.

Which signs were listed most often?

accidental exposure (173), no sign (126), vomiting (113), depression (101) and death (86).

Can the count for a month still change?

Yes. FDA posts reports quarterly with a delay of three to six months, so the newest months are incomplete and usually grow in later releases. Older months change little.

Does a busy month mean something went wrong that month?

Not by itself. The date is when FDA received the report, not when the event happened, and volume follows season, product launches and publicity. FDA states that "there is no certainty that the reported drug or device caused the adverse event" and that the event "may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources."

Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 1 Oct 2026. The month is the date FDA first received the report, not the date of the event. No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.