Breed · Cat
Siamese: adverse event reports
FDA breed label "Siamese" · single-breed animals only
FDA's database holds 2,912 reports where the animal's breed is given as "Siamese", shown here as Siamese: 2% of reports about cats. Reports on crossbred animals are left out of breed pages.
156 reports arrived in the 12 months to March 2026, down 25% from 209 in the 12 months before. A breed's count mostly mirrors how common the breed is; registration and ownership figures by breed are not public data, so no per-animal rate can be given.
By active ingredient, the drugs named most often are selamectin, spinosad and cefovecin sodium. Selamectin is named in 16% of this breed's reports, about the same share as in reports about all cats (14.8%).
The terms listed most often are vomiting (15.3%), lethargy (10.9%) and anorexia (9.5%). Vomiting appears in 15.3% of reports, about the same share as in all cat reports (12.5%). 39.8% of reports stating seriousness were classed as serious, against 35.6% for cats overall.
Drugs named most often, by active ingredient
| Active ingredients recorded for the drug | Reports | Share of Siamese reports | Share of all cat reports |
|---|---|---|---|
| Selamectin | 465 | 16% | 14.8% |
| Spinosad | 288 | 9.9% | 7.8% |
| Cefovecin sodium | 216 | 7.4% | 5.8% |
| Fluralaner | 203 | 7% | 7% |
| Imidacloprid + Moxidectin | 164 | 5.6% | 5.5% |
| Frunevetmab | 118 | 4.1% | 5.1% |
| Nitenpyram | 115 | 3.9% | 5.8% |
| Buprenorphine | 114 | 3.9% | 3.7% |
| Meloxicam | 105 | 3.6% | 2.4% |
| Maropitant | 97 | 3.3% | 2.5% |
| Sarolaner + Selamectin | 95 | 3.3% | 5.3% |
| Emodepside + Praziquantel | 87 | 3% | 3.8% |
| Insulin | 75 | 2.6% | 2.4% |
| Cyclosporine | 63 | 2.2% | 2% |
| Robenacoxib | 59 | 2% | 2.2% |
| Amoxicillin | 56 | 1.9% | 1.1% |
| Velagliflozin | 55 | 1.9% | 2.9% |
| Bexagliflozin | 51 | 1.8% | 2.5% |
| Ketamine Hydrochloride | 49 | 1.7% | 2.5% |
| Enrofloxacin | 47 | 1.6% | 1% |
Ordered by report count. Differences from the species column often come from body size (which drugs a breed is prescribed) and from how common the breed was in the years a drug sold most. FDA states that these data cannot be used to estimate risk or to compare one product with another. Brand and manufacturer names are masked by FDA in these records.
Signs listed in reports
share of Siamese reports listing the termall cat reports
- Vomiting15.3%446
- Lethargy[unusually tired or inactive]10.9%317
- Anorexia[not eating]9.5%277
- Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]6.7%194
- Application site alopecia[hair loss where the product was applied]6%176
- Ataxia[unsteady, uncoordinated movement]5.9%171
- Depression[dull, quiet or withdrawn]5.7%167
- Death5.5%159
- Emesis[vomiting]5.5%159
- Behavioural disorder NOS[behaviour change, type not specified]5.4%156
- Weight loss4.9%142
- Diarrhoea[diarrhea]4.7%137
- Hypersalivation[drooling]4.5%132
- Death by euthanasia[the animal was euthanized]4.2%122
- Lack of efficacy - NOS[the product did not have the expected effect]4.1%120
- Application site hair loss[hair loss where the product was applied]3.8%112
- Elevated blood urea nitrogen (BUN)[a kidney value above the normal range]3.4%99
- Dehydration3.3%97
- Not eating3.1%91
- Pruritus[itching]2.9%83
- Elevated creatinine[a kidney value above the normal range]2.8%82
- Hyperactivity2.6%76
- Accidental exposure[exposure that was not intended]2.6%75
- Decreased appetite2.6%75
- Hiding2.4%70
Age and weight
Age of the animal
Weight of the animal
Coloured bar: Siamese reports. Grey bar: all cat reports.
Trend and outcomes
Reports by month FDA received them. The newest months are incomplete because FDA posts reports with a delay of three to six months.
Outcome recorded in the report
Beside all cats
| Measure | Siamese | All cats |
|---|---|---|
| Reports | 2,912 | 148,080 |
| Latest 12 months | 156 | 12,477 |
| Classed serious, of reports stating it | 39.8% | 35.6% |
| Death or euthanasia recorded, per 1,000 reports | 98.6 | 95 |
Questions about Siamese reports
How many FDA adverse event reports involve Siameses?
2,912 reports through March 2026, 2% of reports about cats; 156 in the latest 12 months.
Which drugs are named most often in Siamese reports?
By active ingredient: selamectin (465), spinosad (288), cefovecin sodium (216), fluralaner (203) and imidacloprid + moxidectin (164). Brands are masked in the public data.
What signs are reported most for this breed?
vomiting (15.3%), lethargy (10.9%), anorexia (9.5%), lack of efficacy (ectoparasite) - flea (6.7%) and application site alopecia (6%).
Is the Siamese more sensitive to certain drugs?
Report counts cannot answer that. They show what was reported, not what a drug did, and they are not adjusted for how many Siamese animals exist or were treated. Breed-related drug sensitivities that are established are described on FDA-approved labels; a veterinarian is the person to ask about an individual animal.
Why are crossbreds not included?
FDA records crossbred animals with one or more component breeds. Counting them under each component would double count, so breed pages use single-breed reports only. Crossbreds remain in the species totals.
How do I report a problem?
Call the drug company using the number on the label, or send Form FDA 1932a to FDA. See the guide on how to report.
Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 1 Oct 2026. Breed names are FDA's labels rearranged into everyday order ("Siamese" becomes "Siamese"). No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.