November 2005: adverse event reports received

1,488 reports in the openFDA release of 28 Sep 2026

Read this first · FDA's caveat, in its words

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources. FDA Center for Veterinary Medicine

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Not veterinary advice. This site lists what was reported to FDA. For an animal that is unwell, contact a veterinarian.

1,488reports received

1,725same month a year earlier-14%

1,748monthly average, preceding 12 months

61.6%concern dogscats 7%

FDA's database holds 1,488 adverse event reports received in November 2005, against 1,725 in the same month a year earlier and a monthly average of 1,748 over the preceding 12 months.

61.6% of the month's reports concern dogs, 7% cats and 3.6% horses; the rest concern other species, exposed people, or give no species.

By active ingredient, the drugs named most often were ivermectin + pyrantel pamoate (170), carprofen (146) and selamectin (102), and the terms listed most often were vomiting (200), ineffective, heartworm larvae (172) and anorexia (160). Report volume has a seasonal shape, with more reports in the warmer months when parasite products are in heavier use.

The months around it

Drugs named most often, by active ingredient

Active ingredients recorded for the drug	Reports	Share of the month's reports
Ivermectin + Pyrantel Pamoate	170	11.4%
Carprofen	146	9.8%
Selamectin	102	6.9%
Deracoxib	95	6.4%
Milbemycin Oxime	86	5.8%
Cyclosporine	80	5.4%
Melarsomine Dihydrochloride	72	4.8%
Meloxicam	63	4.2%
Firocoxib	51	3.4%
Ivermectin	37	2.5%
Lufenuron + Milbemycin Oxime	31	2.1%
Tilmicosin Phosphate	29	1.9%
Ivermectin + Praziquantel	27	1.8%
Amoxicillin	24	1.6%
Nitenpyram	23	1.5%

Ordered by report count, which follows how widely each drug was in use. FDA states that these data cannot be used to estimate risk or to compare one product with another. Brand and manufacturer names are masked by FDA in these records.

Signs listed most often

Vomiting13.4%200
Ineffective, heartworm larvae[legacy FDA term: the product did not have the expected effect (heartworm larvae)]11.6%172
Anorexia[not eating]10.8%160
Depression[dull, quiet or withdrawn]10.3%154
Death8.9%133
Accidental exposure[exposure that was not intended]8%119
Diarrhoea[diarrhea]6%89
Elevated serum alkaline phosphatase (SAP)[a liver and bone enzyme above the normal range]5.6%83
Elevated alanine aminotransferase (ALT)[a liver enzyme above the normal range]5%75
Ataxia[unsteady, uncoordinated movement]4.6%68
Death by euthanasia[the animal was euthanized]4.4%65
Elevated blood urea nitrogen (BUN)[a kidney value above the normal range]4%59
Convulsion[seizure]3.8%57
Elevated creatinine[a kidney value above the normal range]3.4%50
Tablets, Abnormal[a product quality report, not a sign in an animal]3%45

Single ingredients, pooled

Ivermectin16%238

Pyrantel Pamoate12.4%184

Carprofen9.8%146

Milbemycin Oxime7.9%117

Selamectin6.9%102

Deracoxib6.4%95

Cyclosporine5.4%80

Melarsomine Dihydrochloride4.8%72

Meloxicam4.2%63

Firocoxib3.4%51

Lufenuron2.5%37

Praziquantel2.4%36

Species

Dog61.6%917

Cat7%104

Horse3.6%53

Other or not given27.8%414

Questions about November 2005

How many animal drug adverse event reports did FDA receive in November 2005?

1,488 reports are in the openFDA release of 28 Sep 2026. The same month a year earlier has 1,725.

Which drugs were named most often?

By active ingredient: ivermectin + pyrantel pamoate (170), carprofen (146), selamectin (102), deracoxib (95) and milbemycin oxime (86). Brands are masked in the public data.

Which signs were listed most often?

vomiting (200), ineffective, heartworm larvae (172), anorexia (160), depression (154) and death (133).

Can the count for a month still change?

Yes. FDA posts reports quarterly with a delay of three to six months, so the newest months are incomplete and usually grow in later releases. Older months change little.

Does a busy month mean something went wrong that month?

Not by itself. The date is when FDA received the report, not when the event happened, and volume follows season, product launches and publicity. FDA states that "there is no certainty that the reported drug or device caused the adverse event" and that the event "may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources."

Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 1 Oct 2026. The month is the date FDA first received the report, not the date of the event. No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.