Species

Drugs named most often, by active ingredient

Ordered by report count, which follows how widely a drug is used. FDA states that these data "cannot be used to estimate the risk associated with the product or compare one drug or device product with another". openFDA masks brand and manufacturer names in adverse event records, so the reports counted here cannot be attributed to a particular brand.

Signs listed in reports

share of rat reports listing the termall species

1. Death53.4%78
2. Ineffective, anesthesia[legacy FDA term: the product did not have the expected effect (anesthesia)]17.1%25
3. Death by euthanasia[the animal was euthanized]10.3%15
4. Lack of efficacy - NOS[the product did not have the expected effect]6.2%9
5. Apnoea[breathing stopped]5.5%8
6. Ineffective, sedation[legacy FDA term: the product did not have the expected effect (sedation)]5.5%8
7. Cyanosis[bluish gums or skin from low oxygen]2.7%4
8. Ataxia[unsteady, uncoordinated movement]2.1%3
9. Cardiac arrest2.1%3
10. Dyspnoea[difficulty breathing]2.1%3
11. Pain NOS[NOS: not otherwise specified]2.1%3
12. Anorexia[not eating]1.4%2
13. Behavioural disorder NOS[behaviour change, type not specified]1.4%2
14. Color, Abnormal[a product quality report, not a sign in an animal]1.4%2
15. Convulsion[seizure]1.4%2
16. Dehydration1.4%2
17. Depression[dull, quiet or withdrawn]1.4%2
18. Dysphagia1.4%2
19. Eye disorder NOS (for Photophobia see neurological)1.4%2
20. Hypothermia[low body temperature]1.4%2
21. Ineffective, delayed effect[legacy FDA term: the product did not have the expected effect (delayed effect)]1.4%2
22. Injection site necrosis[necrosis where the injection was given]1.4%2
23. Medication error NOS[a mistake in giving the product, type not specified]1.4%2
24. Neurological signs NOS[NOS: not otherwise specified]1.4%2
25. Not eating1.4%2
26. Premature anaesthesia recovery1.4%2
27. Product Defect, General[a product quality report, not a sign in an animal]1.4%2
28. Pruritus[itching]1.4%2
29. Recovery prolonged1.4%2
30. Reluctant to move1.4%2

Single ingredients, pooled across combinations

• Ketamine Hydrochloride64 reports · 43.8%
• Isoflurane17 reports · 11.6%
• Xylazine13 reports · 8.9%
• Selamectin9 reports · 6.2%
• Dexmedetomidine hydrochloride7 reports · 4.8%
• Buprenorphine6 reports · 4.1%
• Ivermectin6 reports · 4.1%
• Enrofloxacin5 reports · 3.4%
• Carprofen4 reports · 2.7%
• Xylazine Hydrochloride4 reports · 2.7%
• Atipamezole Hydrochloride3 reports · 2.1%
• Medetomidine3 reports · 2.1%
• Meloxicam3 reports · 2.1%
• Gentamicin Sulfate2 reports · 1.4%
• Acepromazine Maleate1 reports · 0.7%
• Alfaxalone1 reports · 0.7%

Age and weight

Outcomes and report types

Coloured bar: rat reports. Grey bar: all 1,357,245 reports. Outcomes are as stated by the reporter.

Trend

Reports by month FDA received them. The newest months are incomplete because FDA posts reports with a delay of three to six months.

Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 1 Oct 2026. No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.