Neomycin Sulfate (Biosol, Neomix): adverse event reports that FDA received
Active ingredient
Also sold as: Biosol, Neomix, NeoMed, Neo-Sol, Neo 200.
The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.
Read this first. FDA says this about the data:
An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .
This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.
Contacting a veterinarianHow to report to FDAFrom September 1988 to August 2025, FDA received 34 adverse event reports that name a drug with neomycin sulfate as its active ingredient. Of the 34 reports, 10 (29.4%) are about dogs. 7 reports are about cattle (20.6%).
In January to March 2026, FDA received no reports that name this drug. The sign that appears in the largest number of the 34 reports is "Residues in meat/offal". A report is not proof that a drug caused a sign.
Fewer than 20 reports named this drug in the 12 months before June 2026, so this page gives no change.
Search engines list a drug page with 500 reports or more in all years. The page also needs 30 reports or more in the 12 months to June 2026. This page is under one of these numbers. The site keeps the page and keeps it out of search engines.
Since the last update of the FDA data
The latest update of the FDA data, recorded on , changed no count of this page.
January to March 2026 is the latest closed quarter in the data. In that quarter FDA received 0 reports that name neomycin sulfate: 0 dog, 0 cat, 0 horse, 0 other or not given.
Signs that the reports list
A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 34 reports that list the sign. One report can list more than one sign.
The sign that is in the largest number of the reports comes first.
- Residues in meat/offal14.7%5 reports
- Death-slaughtered8.8%3 reports
- Color, Abnormal[a product quality report, not a sign in an animal]5.9%2 reports
- Containers, Abnormal[a product quality report, not a sign in an animal]5.9%2 reports
- Diarrhoea[diarrhea]5.9%2 reports
- Granules/Powder, Abnormal5.9%2 reports
- Lack of efficacy (protozoa) - NOS[the product did not have the expected effect: target not specified]5.9%2 reports
- Odor, Abnormal[a product quality report, not a sign in an animal]5.9%2 reports
- Residues in milk5.9%2 reports
- Accidental exposure[exposure that was not intended]2.9%1 reports
- Allergic reaction2.9%1 reports
- Application site bleeding[bleeding where the product was applied]2.9%1 reports
- Application site crust[crust where the product was applied]2.9%1 reports
- Application site hair loss[hair loss where the product was applied]2.9%1 reports
Show the next 16 signs
- Ataxia[unsteady, uncoordinated movement]2.9%1 reports
- Bumping into walls2.9%1 reports
- Cataract2.9%1 reports
- Circling - neurological disorder2.9%1 reports
- Conjunctivitis2.9%1 reports
- Corneal disorder NOS[NOS: not otherwise specified]2.9%1 reports
- Corneal ulcer2.9%1 reports
- Cough2.9%1 reports
- Deafness2.9%1 reports
- Death2.9%1 reports
- Death by euthanasia[the animal was euthanized]2.9%1 reports
- Dental plaque2.9%1 reports
- Dermatitis[inflamed skin]2.9%1 reports
- Elevated alanine aminotransferase (ALT)[a liver enzyme above the normal range]2.9%1 reports
- Elevated serum alkaline phosphatase (SAP)[a liver and bone enzyme above the normal range]2.9%1 reports
- Emesis[vomiting]2.9%1 reports
The list shows 30 of 65 coded signs. A report is not proof that a drug caused a sign. Download all signs (CSV)
Reports by species
The share is of all 34 reports that name neomycin sulfate. The other reports give a different species or no species.
Reports for each month, Jul 2021 to Jun 2026
No chart: no month has 5 or more reports.
No chart: no month has 5 or more reports.
No chart: no month has 5 or more reports.
No chart: no month has 5 or more reports.
The month is the month in which FDA received the report. Each chart has its own scale. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
Reports by year
- Dog
- Cat
- Horse
- Other or not given
| Year | Dog | Cat | Horse | Other or not given | All species |
|---|---|---|---|---|---|
| 2025 | 1 | 0 | 0 | 0 | 1 |
| 2024 | 1 | 0 | 0 | 0 | 1 |
| 2020 | 0 | 1 | 0 | 0 | 1 |
| 2019 | 1 | 0 | 0 | 0 | 1 |
| 2018 | 0 | 0 | 0 | 1 | 1 |
| 2013 | 2 | 0 | 0 | 0 | 2 |
| 2012 | 2 | 0 | 0 | 2 | 4 |
| 2011 | 0 | 0 | 0 | 2 | 2 |
| 2010 | 0 | 0 | 0 | 1 | 1 |
| 2009 | 0 | 0 | 0 | 1 | 1 |
| 2008 | 0 | 0 | 0 | 2 | 2 |
| 2007 | 0 | 0 | 0 | 2 | 2 |
| 2006 | 2 | 0 | 0 | 3 | 5 |
| 2004 | 0 | 0 | 0 | 1 | 1 |
| 2003 | 0 | 0 | 0 | 3 | 3 |
| 2002 | 0 | 0 | 0 | 1 | 1 |
| 2001 | 1 | 0 | 0 | 1 | 2 |
| 1995 | 0 | 1 | 0 | 1 | 2 |
| 1988 | 0 | 1 | 0 | 0 | 1 |
2025 has the reports that FDA received through Aug 2025. Download the years (CSV)
What the reports record
Outcome at the time of the report
- Recovered/Normal11.8%4
- Recovered with Sequela[recovered, with a lasting effect]0%0
- Ongoing11.8%4
- Died14.7%5
- Euthanized0%0
- Outcome Unknown5.9%2
An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 34 reports that name neomycin sulfate.
A report about more than one animal can have more than one outcome.
Kind of report
- Safety issue61.8%21
- Lack of expected effectiveness0%0
- Both safety and lack of expected effectiveness5.9%2
- Manufacturing or product defect32.4%11
- Other0%0
9 reports say if the event was serious. 44.4% of them have the serious flag. The person who sends the report sets the flag.
Show age, weight, breed and route
Age of the animal
- Under 1 year8.8%3
- 1 to 3 years8.8%3
- 4 to 7 years11.8%4
- 8 to 11 years11.8%4
- 12 years and over2.9%1
- Age not given55.9%19
Weight of the animal
- Under 5 kg (11 lb)8.8%3
- 5 to 9.9 kg (11 to 22 lb)2.9%1
- 10 to 24.9 kg (22 to 55 lb)8.8%3
- 25 to 44.9 kg (55 to 99 lb)11.8%4
- 45 kg and over (99 lb and over)14.7%5
- Weight not given52.9%18
Breed, where the report gives one breed
- Holstein-Friesian14.7%5
- Bichon Frise5.9%2
- Labrador Retriever5.9%2
- Shetland Sheepdog5.9%2
- Jersey2.9%1
- Domestic2.9%1
- Domestic Longhair2.9%1
- American Pit Bull Terrier2.9%1
A breed with many animals has many reports.
Route in the report
- Oral35.3%12
- Ophthalmic11.8%4
- Intramammary2.9%1
- Topical2.9%1
Each bar is on a scale of 0 to 100%.
Approved animal drugs with this active ingredient (FDA Green Book)
This section is reference data. It has no report count.
The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.
Brand names
- Biosol
- Neomix
- NeoMed
- Neo-Sol
- Neo 200
What the Green Book records give
- Applications with an approval in force
- 12
- Approved species
- Cattle, Goats, Sheep, Swine, Turkeys, Cats, Dogs
- Dose forms
- Liquid (Solution), Powder for oral solution, Soluble Powder, Type A Medicated Article, Powder for oral suspension
- Routes
- Oral, Intramuscular, Intravenous
- Sale
- RX (prescription), VFD (veterinary feed directive)
- Earliest approval date in the records
The species, dose forms and routes are the words of the Green Book records for all the applications together. One product can have fewer. The label of a product gives its approved use.
| Brand name | Active ingredients | Sponsor | Approved species | Application |
|---|---|---|---|---|
| Neomix 325 Soluble Powder; Neomix AG 325 Soluble Powder | Neomycin Sulfate | Phibro Animal Health Corp. | Cattle, Swine, Turkeys, Sheep, Goats | NADA 011-315 |
| Biosol Sterile Solution; Biosol Sterile Solution 50 mg | Neomycin Sulfate | Zoetis Inc. | Dogs, Cats | NADA 011-953 |
| Neomix Ag 325; Neomix 325 | Neomycin Sulfate | Phibro Animal Health Corp. | Cattle, Swine, Sheep, Goats | NADA 140-976 |
| Neomycin Sulfate | Neomycin Sulfate | Phibro Animal Health Corp. | Cattle, Swine, Sheep, Goats | ANADA 200-046 |
| NeoMed Soluble Powder | Neomycin Sulfate | Bimeda Animal Health Ltd. | Cattle, Swine, Turkeys, Sheep, Goats | ANADA 200-050 |
| Biosol Liquid | Neomycin Sulfate | Zoetis Inc. | Cattle, Swine, Sheep, Goats | ANADA 200-113 |
| Neomycin Oral Solution | Neomycin Sulfate | Huvepharma EOOD | Cattle, Swine, Sheep, Goats | ANADA 200-118 |
| Neo-Sol 50 | Neomycin Sulfate | Huvepharma EOOD | Cattle, Swine, Turkeys, Sheep, Goats | ANADA 200-130 |
| Neo 200 Oral Solution | Neomycin Sulfate | Huvepharma EOOD | Cattle, Swine, Sheep, Goats | ANADA 200-153 |
| Neosol Soluble Powder | Neomycin Sulfate | Dechra Veterinary Products LLC | Cattle, Swine, Sheep, Goats | ANADA 200-235 |
| Neomycin Sulfate 325 | Neomycin Sulfate | Sparhawk Laboratories, Inc. | Cattle, Swine, Turkeys, Sheep, Goats | ANADA 200-378 |
| Neomycin Liquid | Neomycin Sulfate | Sparhawk Laboratories, Inc. | Cattle, Swine, Sheep, Goats | ANADA 200-379 |
| Neomycane Ophthalmic Ointmentapproval withdrawn | Neomycin Sulfate | Evsco Pharmaceuticals, An Affiliate of IGI, Inc. | Dogs, Cats | NADA 044-655 |
| Neosol-Oralapproval withdrawn | Neomycin Sulfate | Med-Pharmex, Inc. | Cattle, Swine, Turkeys, Sheep, Goats | ANADA 200-289 |
Other pages with this ingredient
A report names a drug by its set of active ingredients. Each set has its own page. The list is in order of name.
- Neomycin Sulfate, all combinations
- Dexamethasone + Neomycin Sulfate + Polymyxin B Sulfate
- Dexamethasone + Neomycin Sulfate + Thiabendazole
- Isoflupredone Acetate + Neomycin Sulfate + Tetracaine Hydrochloride
- Neomycin Sulfate + Nystatin
- Neomycin Sulfate + Nystatin + Thiostrepton
- Neomycin Sulfate + Nystatin + Thiostrepton + Triamcinolone Acetonide
- Neomycin Sulfate + Tetracaine Hydrochloride
FDA pages for this drug
- How to Report Animal Drug and Device Side Effects and Product ProblemsThe FDA page that tells an owner or a veterinarian how to send a report.
- Green Book record of NADA 011-953The FDA record of the application for Biosol Sterile Solution, Biosol Sterile Solution 50 mg.
- Green Book record of NADA 011-315The FDA record of the application for Neomix 325 Soluble Powder, Neomix AG 325 Soluble Powder.
- Green Book record of NADA 140-976The FDA record of the application for Neomix Ag 325, Neomix 325.
- Green Book record of ANADA 200-046The FDA record of the application for Neomycin Sulfate.
- Green Book record of ANADA 200-050The FDA record of the application for NeoMed Soluble Powder.
- Green Book record of ANADA 200-113The FDA record of the application for Biosol Liquid.
- Animal Drugs @ FDAThe search page of the Green Book, the FDA list of approved animal drugs.
The site checked these addresses on . The links open in a new tab.
Cite this page
Pet Drug Reports. Neomycin Sulfate: adverse event reports that FDA received. https://petdrugreports.com/drug/neomycin-sulfate/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .
Where the data come from
The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site does not use the application number that a record has.
The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.
Questions about these reports
- Which brand are these reports about?
The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. The Green Book section of this page lists the brand names with this active ingredient.
- Do the reports show that the drug caused the signs?
No. FDA states this about the data.
When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices
- How many reports did FDA receive in the latest 12 months?
FDA received 1 report in the 12 months to June 2026. It received no reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
- What kinds of report are in the count?
Of the 34 reports received from September 1988 to August 2025, 61.8% are about a safety issue only. 5.9% are about a lack of expected effectiveness, alone or with a safety issue. 32.4% are about a defect of the product or its package.