Pet Drug Reports

Estradiol + Testosteroneadverse event reports that FDA received

Combination of 2 active ingredients

The Green Book lists no brand name for exactly these active ingredients.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarianHow to report to FDA

From July 1987 to August 2011, FDA received 47 adverse event reports that name a drug with estradiol and testosterone as its active ingredients. Of the 47 reports, 24 (51.1%) are about cattle.

In January to March 2026, FDA received no reports that name this drug. The signs that appear in the largest number of the 47 reports are "Implant, Abnormal", "Death" and "Underfilling, Package". A report is not proof that a drug caused a sign.

Fewer than 20 reports named this drug in the 12 months before June 2026, so this page gives no change. Reports about cattle are 51.1% of the reports that name this drug, and 2.3% of all reports.

Search engines list a drug page with 500 reports or more in all years. The page also needs 30 reports or more in the 12 months to June 2026. This page is under one of these numbers. The site keeps the page and keeps it out of search engines.

Since the last update of the FDA data

The latest update of the FDA data, recorded on , changed no count of this page.

January to March 2026 is the latest closed quarter in the data. In that quarter FDA received 0 reports that name estradiol + testosterone: 0 dog, 0 cat, 0 horse, 0 other or not given.

All updatesFeed of updates (RSS)

Signs that the reports list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 47 reports that list the sign. One report can list more than one sign.

The sign that is in the largest number of the reports comes first.

  1. Implant, Abnormal23.4%11 reports
  2. Death21.3%10 reports
  3. Underfilling, Package[a product quality report, not a sign in an animal]21.3%10 reports
  4. Vaginal prolapse17%8 reports
  5. Mammary gland oedema12.8%6 reports
  6. Dispenser, Abnormal[a product quality report, not a sign in an animal]8.5%4 reports
  7. Hypersalivation[drooling]8.5%4 reports
  8. Rectal prolapse8.5%4 reports
  9. Dyspnoea[difficulty breathing]6.4%3 reports
  10. Facial oedema[swollen face]4.3%2 reports
  11. Granules/Powder, Abnormal4.3%2 reports
  12. Increased sexual interest4.3%2 reports
  13. Mammary gland disorder NOS[NOS: not otherwise specified]4.3%2 reports
  14. No sign[no clinical sign was reported]4.3%2 reports
Show the next 16 signs
  1. Product Defect, General[a product quality report, not a sign in an animal]4.3%2 reports
  2. Abdominal pain2.1%1 reports
  3. Abnormal breathing2.1%1 reports
  4. Anaphylaxis[sudden severe allergic-type reaction]2.1%1 reports
  5. Application site swelling[swelling where the product was applied]2.1%1 reports
  6. Applicator, Abnormal[a product quality report, not a sign in an animal]2.1%1 reports
  7. Behavioural disorder NOS[behaviour change, type not specified]2.1%1 reports
  8. Containers, Abnormal[a product quality report, not a sign in an animal]2.1%1 reports
  9. Death-slaughtered2.1%1 reports
  10. Depression[dull, quiet or withdrawn]2.1%1 reports
  11. Excessive licking and/or grooming2.1%1 reports
  12. External ear disorder NOS[NOS: not otherwise specified]2.1%1 reports
  13. Fever2.1%1 reports
  14. Pinnal oedema2.1%1 reports
  15. Recumbency[lying down and unable or unwilling to rise]2.1%1 reports
  16. Shaking2.1%1 reports

The list shows 30 of 35 coded signs. A report is not proof that a drug caused a sign. Download all signs (CSV)

Reports by species

The share is of all 47 reports that name estradiol + testosterone. The other reports give a different species or no species.

Reports for each month, Jul 2021 to Jun 2026

Dog0 reports

No chart: no month has 5 or more reports.

Cat0 reports

No chart: no month has 5 or more reports.

Horse0 reports

No chart: no month has 5 or more reports.

Other or not given0 reports

No chart: no month has 5 or more reports.

The month is the month in which FDA received the report. Each chart has its own scale. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports by year

  • Dog
  • Cat
  • Horse
  • Other or not given
Reports that name estradiol + testosterone, by the year in which FDA received them and by species
YearDogCatHorseOther or not givenAll species
201100066
201000044
200900022
200700022
200600011
200500011
200400022
200300022
200200044
200100055
200000055
199900066
199800022
199700011
199400011
199000011
198800011
198700011

2011 has the reports that FDA received through Aug 2011. Download the years (CSV)

What the reports record

Outcome at the time of the report

  • Recovered/Normal0%0
  • Recovered with Sequela[recovered, with a lasting effect]0%0
  • Ongoing0%0
  • Died19.1%9
  • Euthanized0%0
  • Outcome Unknown0%0

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 47 reports that name estradiol + testosterone.

A report about more than one animal can have more than one outcome.

Kind of report

  • Safety issue51.1%24
  • Lack of expected effectiveness0%0
  • Both safety and lack of expected effectiveness0%0
  • Manufacturing or product defect48.9%23
  • Other0%0
Show age, weight, breed and route

Age of the animal

  • Under 1 year19.1%9
  • 1 to 3 years10.6%5
  • 4 to 7 years0%0
  • 8 to 11 years0%0
  • 12 years and over0%0
  • Age not given70.2%33

Weight of the animal

  • Under 5 kg (11 lb)0%0
  • 5 to 9.9 kg (11 to 22 lb)0%0
  • 10 to 24.9 kg (22 to 55 lb)0%0
  • 25 to 44.9 kg (55 to 99 lb)0%0
  • 45 kg and over (99 lb and over)34%16
  • Weight not given66%31

Breed, where the report gives one breed

A breed with many animals has many reports.

Route in the report

  • Subcutaneous42.6%20
  • Intradermal6.4%3

Each bar is on a scale of 0 to 100%.

Approved animal drugs with these active ingredients (FDA Green Book)

This section is reference data. It has no report count.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

No approved product has exactly this set of active ingredients. The ingredient field of a report can be incomplete. The approved products below have all the ingredients of this page and one or more other ingredients.

Applications in the Green Book of 2 Nov 2026, pioneer applications (NADA) first
Brand nameActive ingredientsSponsorApproved speciesApplication
Component E-H with TylanEstradiol, Testosterone, TylosinElanco US Inc.CattleNADA 135-906

Other pages with one of these ingredients

A report names a drug by its set of active ingredients. Each set has its own page. The list is in order of name.

FDA pages for this drug

The site checked these addresses on . The links open in a new tab.

Cite this page

Pet Drug Reports. Estradiol + Testosterone: adverse event reports that FDA received. https://petdrugreports.com/drug/estradiol-testosterone/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site does not use the application number that a record has.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about these reports

Which brand are these reports about?

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. The Green Book lists no brand name for exactly these active ingredients.

Do the reports show that the drug caused the signs?

No. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

How many reports did FDA receive in the latest 12 months?

FDA received no reports in the 12 months to June 2026. It received no reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

What kinds of report are in the count?

Of the 47 reports received from July 1987 to August 2011, 51.1% are about a safety issue only. 48.9% are about a defect of the product or its package.